Ethanol administration impairs pancreatic repair after injury

Pancreas

Volumn 41, Issue 8, 2012, Pages 1272-1279

  Schneider, Katrina J Mahan ^a   Scheer, Marc ^b   Suhr, Mallory ^b   Clemens, Dahn L ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

acute pancreatitis; alcoholic pancreatitis; coxsackievirus; developmental factors; ethanol; tissue repair

Indexed keywords

ALCOHOL; AMYLASE; PROTEIN P48; TRANSCRIPTION FACTOR HES 1; TRIACYLGLYCEROL LIPASE;

ACINAR CELL; ALCOHOL CONSUMPTION; ALCOHOLIC PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS INFECTION; HISTOLOGY; IMMUNOBLOTTING; MOUSE; NONHUMAN; PANCREAS INJURY; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DIFFERENTIATION; TISSUE REGENERATION; TISSUE REPAIR;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; COXSACKIEVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LIPASE; MICE; MICE, INBRED C57BL; PANCREAS; PANCREATITIS, ALCOHOLIC; REGENERATION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 84868303050     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31824bde37     Document Type: Article

References (46)

1. Ammann RW, Heitz PU, Kloppel G. Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study. Gastroenterology. 1996;111(1):224-231.
2. Wang GJ, Gao CF, Wei D, et al. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol. 2009;15(12): 1427-1430.
3. Friederich N. Disease of the pancreas. In: Cyclopaedia of the Practice of Medicine. Vol. 18-18. New York, NY: William Wood; 1878:254-312.
4. Apte MV, Pirola RC, Wilson JS. Mechanisms of alcoholic pancreatitis. J Gastroenterol Hepatol. 2010;25(12):1816-1826.
5. Oruc N, Whitcomb DC. Theories, mechanisms, and models of alcoholic chronic pancreatitis. Gastroenterol Clin North Am. 2004;33(4):733-750.
6. Haber PS, Apte MV, Applegate TL, et al. Metabolism of ethanol by rat pancreatic acinar cells. J Lab Clin Med. 1998;132(4):294-302.
7. Laposata EA, Lange LG. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science. 1986;231(4737):497-499.
8. Norton ID, Apte MV, Haber PS, et al. Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration. Gut. 1998;42(3):426-430.
9. Gukovskaya AS, Mouria M, Gukovsky I, et al. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology. 2002;122(1):106-118.
10. Masamune A, Kikuta K, Satoh M, et al. Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. J Pharmacol Exp Ther. 2002;302(1):36-42.
11. Masamune A, Satoh A, Watanabe T, et al. Effects of ethanol and its metabolites on human pancreatic stellate cells. Dig Dis Sci. 2010;55(1):204-211.
12. Hamamoto T, Yamada S, Hirayama C. Nonoxidative metabolism of ethanol in the pancreas; implication in alcoholic pancreatic damage. Biochem Pharmacol. 1990;39(2):241-245.
13. Werner J, Laposata M, Fernandez-del Castillo C, et al. Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology. 1997;113(1):286-294.
14. Desai BM, Oliver-Krasinski J, De Leon DD, et al. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest. 2007;117(4):971-977.
15. Fendrich V, Esni F, Garay MV, et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology. 2008;135(2):621-631.
16. Jensen JN, Cameron E, Garay MV, et al. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology. 2005;128(3):728-741.
17. Siveke JT, Lubeseder-Martellato C, Lee M, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology. 2008;134(2):544-555.
18. Clemens DL, Jerrells TR. Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: preliminary findings. Alcohol. 2004;33(3):183-189.
19. Jerrells TR, Chapman N, Clemens DL. Animal model of alcoholic pancreatitis: role of viral infections. Pancreas. 2003;27(4):301-304.
20. Jerrells TR, Vidlak D, Strachota JM. Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis. J Leukoc Biol. 2007;81(2):430-439.
21. Tracy S, Hofling K, Pirruccello S, et al. Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice. J Med Virol. 2000;62(1):70-81.
22. Song K, Coleman RA, Zhu X, et al. Chronic ethanol consumption by mice results in activated splenic T cells. J Leukoc Biol. 2002;72(6):1109-1116.
23. Jamal MM, Morgan TR. Liver disease in alcohol and hepatitis C. Best Pract Res Clin Gastroenterol. 2003;17(4):649-662.
24. Jerrells TR, Pavlik JA, DeVasure J, et al. Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice. Alcohol. 2007;41(5):357-369.
25. Sepulveda RT, Jiang S, Besselsen DG, et al. Alcohol consumption during murine acquired immunodeficiency syndrome accentuates heart pathology due to coxsackievirus. Alcohol Alcohol. 2002;37(2):157-163.
26. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(jDelta Delta C(T)) method. Methods. 2001;25(4):402-408.
27. Imrie CW, Ferguson JC, Sommerville RG. Coxsackie and mumpsvirus infection in a prospective study of acute pancreatitis. Gut. 1977;18(1):53-56.
28. Chrysos G, Kokkoris S, Protopsaltis J, et al. Coxsackievirus infection associated with acute pancreatitis. JOP. 2004;5(5):384-387.
29. Parenti DM, Steinberg W, Kang P. Infectious causes of acute pancreatitis. Pancreas. 1996;13(4):356-371.
30. Clemens DL, Calisto LE, Sorrell MF, et al. Ethanol metabolism results in a G2/M cell-cycle arrest in recombinant Hep G2 cells. Hepatology. 2003;38(2):385-393.
31. Slack JM. Developmental biology of the pancreas. Development. 1995;121(6):1569-1580.
32. Gomez G, Englander EW, Wang G, et al. Increased expression of hypoxia-inducible factor-1alpha, p48, and the Notch signaling cascade during acute pancreatitis in mice. Pancreas. 2004;28(1):58-64.
33. Clemens DL, Forman A, Jerrells TR, et al. Relationship between acetaldehyde levels and cell survival in ethanol-metabolizing hepatoma cells. Hepatology. 2002;35(5):1196-1204.
34. Koteish A, Yang S, Lin H, et al. Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. Alcohol Clin Exp Res. 2002;26(11):1710-1718.
35. Yang SQ, Lin HZ, Yin M, et al. Effects of chronic ethanol consumption on cytokine regulation of liver regeneration. Am J Physiol. 1998;275(4 Pt 1):G696-G704.
36. Jung Y, Brown KD, Witek RP, et al. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology. 2008;134(5):1532-1543.
37. Syn WK, Choi SS, Liaskou E, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology. 2011;53(1):106-115.
38. Cano DA, Hebrok M. Hedgehog spikes pancreas regeneration. Gastroenterology. 2008;135(2):347-351.
39. Reid LE, Walker NI. Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis. Int J Exp Pathol. 1999;80(4):205-215.
40. Fujikura J, Hosoda K, Kawaguchi Y, et al. Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development. Dev Dyn. 2007;236(10):2779-2791.
41. Masui T, Long Q, Beres TM, et al. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev. 2007;21(20):2629-2643.
42. Taguchi M, Yamaguchi T, Otsuki M. Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats. J Pathol. 2002;197(5):638-646.
43. Wilson A, Radtke F. Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett. 2006;580(12):2860-2868.
44. Apelqvist A, Li H, Sommer L, et al. Notch signalling controls pancreatic cell differentiation. Nature. 1999;400(6747):877-881.
45. Krejs GJ. Pancreatic cancer: epidemiology and risk factors. Dig Dis. 2010;28(2):355-358.
46. De La OJ, Murtaugh LC. Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle. 2009;8(12):1860-1864.