Association of prion protein with cognitive functioning in humans

Experimental Gerontology

Volumn 47, Issue 12, 2012, Pages 919-924

  Breitling, Lutz Philipp ^a   Müller, Heiko ^a   Stegmaier, Christa ^b   Kliegel, Matthias ^c   Brenner, Hermann ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Saarland Cancer Registry   (Germany)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Cognition; Epidemiological study; Executive function; Homo sapiens; Prion protein

Indexed keywords

PRION PROTEIN;

AGED; ARTICLE; COGNITION; CROSS-SECTIONAL STUDY; FEMALE; GERMANY; HUMAN; HUMAN EXPERIMENT; IMMUNOASSAY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCORING SYSTEM; TELECONSULTATION;

AGED; AGING; BIOLOGICAL MARKERS; COGNITION; CROSS-SECTIONAL STUDIES; EXECUTIVE FUNCTION; FEMALE; GERMANY; HUMANS; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; PRIONS;

ANIMALIA; HOMO SAPIENS;

EID: 84868302274     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.08.001     Document Type: Article

References (31)

1. Aguzzi A., Baumann F., Bremer J. The prion's elusive reason for being. Annu. Rev. Neurosci. 2008, 31:439-477.
2. Alier K., Ma L., Yang J., Westaway D., Jhamandas J.H. Aβ inhibition of ionic conductance in mouse basal forebrain neurons is dependent upon the cellular prion protein PrPc. J. Neurosci. 2011, 31(45):16292-16297.
3. Balducci C., Beeg M., Stravalaci M., et al. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(5):2295-2300.
4. Barry A.E., Klyubin I., Mc Donald J.M., et al. Alzheimer's disease brain-derived amyloid-beta-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J. Neurosci. 2011, 31(20):7259-7263.
5. Bate C., Williams A. Amyloid-β-induced synapse damage is mediated via cross-linkage of the cellular prion protein. J. Biol. Chem. 2011, 286(44):37955-37963. (Nov 4, Epub 2011 Sep 7).
6. Bischkopf J., Busse A., Angermeyer M.C. Mild cognitive impairment-a review of prevalence, incidence and outcome according to current approaches. Acta Psychiatr. Scand. 2002, 106(6):403-414.
7. Breitling L.P., Wolf M., Muller H., et al. Large-scale application of a telephone-based test of cognitive functioning in older adults. Dement. Geriatr. Cogn. Disord. 2010, 30(4):309-316.
8. Chung E., Ji Y., Sun Y., et al. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010, 11:130.
9. Cisse M., Mucke L. Alzheimer's disease: a prion protein connection. Nature 2009, 457(7233):1090-1091.
10. Crawford J.R., Henry J.D. Assessment of executive deficits. The effectiveness of rehabilitation for cognitive deficits 2005, 233-246. Oxford University Press, London. P.W. Halligan, N. Wade (Eds.).
11. Desquilbet L., Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. Stat. Med. 2010, 29:1037-1057.
12. Duron E., Hanon O. Vascular risk factors, cognitive decline, and dementia. Vasc. Health Risk Manag. 2008, 4(2):363-381.
13. Freir D.B., Nicoll A.J., Klyubin I., et al. Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nat. Commun. 2011, 2:336.
14. Gimbel D.A., Nygaard H.B., Coffey E.E., et al. Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 2010, 30(18):6367-6374.
15. Kessels H.W., Nguyen L.N., Nabavi S., Malinow R. The prion protein as a receptor for amyloid-beta. Nature 2010, 466(7308):E3-E4. (discussion E-5).
16. Kliegel M., Martin M., Jager T. Development and validation of the Cognitive Telephone Screening Instrument (COGTEL) for the assessment of cognitive function across adulthood. J. Psychol. 2007, 141(2):147-170.
17. Kudo W., Lee H.P., Zou W.Q., et al. Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death. Hum. Mol. Genet. 2012, 21(5):1138-1144.
18. Lauren J., Gimbel D.A., Nygaard H.B., Gilbert J.W., Strittmatter S.M. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009, 457(7233):1128-1132.
19. Ledford H. Key Alzheimer's findings questioned. Nature 2010, 466(7310):1031.
20. Levey A.S., Stevens L.A., Schmid C.H., et al. A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 2009, 150(9):604-612.
21. Low M., Stegmaier C., Ziegler H., Rothenbacher D., Brenner H. Epidemiological investigations of the chances of preventing, recognizing early and optimally treating chronic diseases in an elderly population (ESTHER study). Dtsch. Med. Wochenschr. 2004, 129(49):2643-2647.
22. Lubin J.H., Colt J.S., Camann D., et al. Epidemiologic evaluation of measurement data in the presence of detection limits. Environ. Health Perspect. 2004, 112(17):1691-1696.
23. Nygaard H.B., Strittmatter S.M. Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease. Arch. Neurol. 2009, 66(11):1325-1328.
24. Reitz C., Brayne C., Mayeux R. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 2011, 7(3):137-152.
25. Resenberger U.K., Harmeier A., Woerner A.C., et al. The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. EMBO J. 2011, 30:2057-2070.
26. Roucou X., LeBlanc A.C. Cellular prion protein neuroprotective function: implications in prion diseases. J. Mol. Med. 2005, 83(1):3-11.
27. Saijo E., Scheff S.W., Telling G.C. Unaltered prion protein expression in Alzheimer disease patients. Prion 2011, 5(2):109-116.
28. SAS Institute Statistical analysis software, release 9.2 2008, SAS Institute, Cary, NC.
29. Starke R., Mackie I., Drummond O., et al. Prion protein in patients with renal failure. Transfus. Med. 2006, 16(3):165-168.
30. Volkel D., Zimmermann K., Zerr I., et al. Immunochemical determination of cellular prion protein in plasma from healthy subjects and patients with sporadic CJD or other neurologic diseases. Transfusion 2001, 41(4):441-448.
31. Whitehouse I.J., Jackson C., Turner A.J., Hooper N.M. Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J. Alzheimers Dis. 2010, 22(3):1023-1031.