Resistance training reduces subclinical inflammation in obese, postmenopausal women

Medicine and Science in Sports and Exercise

Volumn 44, Issue 11, 2012, Pages 2099-2110

  Phillips, Melody D ^a   Patrizi, Robert M ^a   Cheek, Dennis J ^a   Wooten, Joshua S ^b   Barbee, James J ^c   Mitchell, Joel B ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

^b TEXAS WOMAN'S UNIVERSITY   (United States)

^c JPS Health Network   (United States)

Author keywords

adipose tissue; CRP; IL 10; IL 6; Leptin; lipopolysaccharide (LPS); TNF

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BLOOD; BODY CONSTITUTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; INFLAMMATION; MIDDLE AGED; MUSCLE STRENGTH; OBESITY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; BIOLOGICAL MARKERS; BODY CONSTITUTION; C-REACTIVE PROTEIN; CHEMOKINE CCL2; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MIDDLE AGED; MUSCLE STRENGTH; OBESITY; POSTMENOPAUSE; RESISTANCE TRAINING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84868301797     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e3182644984     Document Type: Article

References (48)

1. Arikawa AY, Thomas W, Schmitz KH, Kurzer MS. Sixteen weeks of exercise reduces C-reactive protein levels in young women. Med Sci Sports Exerc. 2011;43(6):1002-9.
2. Balducci S, Zanuso S, Nicolucci A, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis. 2010;20:608-17.
3. Bastard JP, Cuevas J, Cohen S, Jardel C, Hainque B. Percutaneous adipose tissue biopsy by mini-liposuction for metabolic studies. J Parenter Enteral Nutr. 1994;18(5):466-8.
4. Berggren JR, Hulver MW, Houmard JA. Role of exercise in reducing the risk of diabetes and obesity. J Appl Physiol. 2005;99: 757-64.
5. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sports Med. 2010;44:620-30.
6. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in dietinduced obese mice. Am J Physiol Endocrinol Metab. 2008;295: E586-94.
7. Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 2006;290:E961-7.
8. Calle MC, Fernandez ML. Effects of resistance training on the inflammatory response. Nutr Res Pract. 2010;4(4):259-69.
9. Campbell PT, Campbell KL, Wener MH, et al. A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc. 2009;41(8):1533-9.
10. Christiansen T, Richelsen B, Bruun JM. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes. 2005;29:146-50.
11. Church TS, Earnest CP, Thompson AM, et al. Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc. 2010;42(4):708-16.
12. Dekker MJ, Lee S, Hudson R, et al. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism. 2007;56:332-8.
13. de Salles BF, Simão R, Fleck SJ, Dias I, Draemer-Aguiar LG, Bouskela E. Effects of resistance training on cytokines. Int J Sports Med. 2010;31(7):441-50.
14. Donges CE, Duffield R, Drinkwater EJ. Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc. 2010;42(2):304-13.
15. Fatouros IG, Tournis S, Leontsini D, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab. 2005;90:5970-7.
16. Flynn MG, McFarlin BK, Phillips MD, Stewart LK, Timmerman KL. Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise-trained elderly women. J Appl Physiol. 2003;95(5): 1833-42.
17. Fresno M, Alvarez R, Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch Physiol Biochem. 2011;117(3): 151-64.
18. Fontana L, Eagon JC, Colonna M, Klein S. Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss. Rejuvenation Res. 2007;10(1):41-6.
19. Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. Resistance exercise decreases skeletal muscle tumor necrosis\factor alpha in frail elderly humans. FASEB J. 2001;15(2):475-82.
20. Henagan TM, Phillips MD, Cheek DJ, KirK KM, Barbee JJ, Stewart LK. The melanocortin 3 receptor: a novel mediator of exercise-induced inflammation reduction in postmenopausal women? J Aging Res. 2011; Article ID 512593.
21. Klimcakova E, Polak J, Moro C, et al. Dynamic strength training mproves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin Endocrin Metab. 2006;91(12):5107-12.
22. Kohut ML, Lee W, Martin A, et al. The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Brain Behav Immun. 2005;19: 357-66.
23. Kohut ML, McCann DA, Russell DW, et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun. 2006;20(3):201-9.
24. Kopp A, Buechler C, Bala M, et al. Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocyte via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3. Endocrinology. 2010;151(3):1097-108.
25. Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol. 2008;105:473-8.
26. Luc G, Bard JM, Juhan-Vague I, et al. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. Arterioscler Thromb Vasc Biol. 2003;23(7):1255-61.
27. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117(1):175-84.
28. Lyon CJ, Law RE, Hsueh WA. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology. 2003;144:2195-200.
29. McFarlin BK, Flynn MG, Campbell WW, Stewart LK, Timmerman KL. TLR4 is lower in resistance-trained older women and related to inflammatory cytokines. Med Sci Sports Exerc. 2004;36(11):1876-83.
30. Mendoza-Nunez VM, Garcia-Sanchez A, Sanchez-Rodriguez M, Galan-Duarte RE, Fonseca-Yerena ME. Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. Obes Res. 2002;10:253-9.
31. Ostan R, Bucci L, Capri M, et al. Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation. 2008; 15(4-6):224-40.
32. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499-511.
33. Pfeilschifter J, Köditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev. 2002; 23(1):90-119.
34. Phillips MD, Flynn MG, McFarlin BK, Stewart LK, Timmerman KL, Ji H. Resistive exercise blunts LPS-stimulated TNF-alpha and Il-1 beta. Int J Sports Med. 2008;29:102-9.
35. Phillips MD, Flynn MG, McFarlin BK, Stewart LK, Timmerman KL. Resistance training at eight-repetition maximum reduces the inflammatory milieu in elderly women. Med Sci Sports Exerc. 2010a;42(2): 314-25.
36. PhillipsMD, Mitchell JB, Currie-Elolf LM, Yellott RC, Hubing KA. Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity. J Strength Cond Res. 2010b;24(4):1091-101.
37. Prestes J, Shiguemoto G, Botero JP, et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci. 2009;27(14):1607-15.
38. Ryan AS, Pratley RE, Elahi D, Goldberg AP. Changes in plasma leptin and insulin action with resistive training in postmenopausal women. Int J Obes Relat Metab Disord. 2000;24(1):27-32.
39. Scholtes BP, Versteeg D, de Vries JP, et al. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. Clin Sci. 2011;121(5): 205-14.
40. Schutte AE, Huisman HW, Schutte R, et al. Adipokines and cardiometabolic function: how are they interlinked?. Regul Pept. 2010;164:133-8.
41. Stewart LK, Flynn MG, Campbell WW, et al. The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc. 2007;39(10):1714-9.
42. Stewart LK, Earnest CP, Blair SN, Church TS. Effects of different doses of physical activity on C-reactive protein among women. Med Sci Sports Exerc. 2010;42(4):701-7.
43. Tanaka M, Suganami T, Sugita S, et al. Role of central leptin signaling in renal macrophage infiltration. Endocr J. 2010;57(1):61-72.
44. Tresierras MA, Balady GJ. Resistance training in the treatment of diabetes and obesity. J Cardiopulm Rehabil Prev. 2009;29:67-75.
45. Tussing-Humphreys L, Pini M, Ponemone V, Braunschweig C, Fantuzzi G. Suppressed cytokine production in whole blood cultures may be related to iron status and hepcidin and is partially corrected following weight reduction in morbidly obese premenopausal women. Cytokine. 2011;53(2):201-6.
46. Vieira VJ, Hu L, Valentine RJ, et al. Reduction in trunk fat predicts cardiovascular exercise training-related reductions in C-reactive protein. Brain Behav Immun. 2009;23:485-91.
47. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-808.
48. Yamaguchi N, Argueta JG, Masuhiro Y, et al. Adiponectin inhibits toll-like receptor family-induced signaling. FEBS Lett. 2005;579 (30):6821-6.