Association between iron status and white blood cell counts in African schoolchildren of the North-West Province, South Africa

Journal of Epidemiology and Global Health

Volumn 2, Issue 3, 2012, Pages 103-110

  Onabanjo, Oluseye O ^a   Jerling, Johann C ^a   Covic, Namukolo ^a   Van Graan, Averalda ^a   Taljaard, Christine ^a   Mamabolo, Ramoteme L ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF VENDA   (South Africa)

Author keywords

African schoolchildren; BeForMi Study; Differential white blood cell counts; Hematological parameters; Iron markers

Indexed keywords

EID: 84868300092     PISSN: 22106006     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jegh.2012.07.003     Document Type: Article

References (45)

1. Kurniawan Y.A., Muslimatun S., Achadi E.L., et al. Anemia and iron deficiency anemia among young adolescent girls from the peri-urban coastal area of Indonesia. Asia Pac J Clin Nutr 2006, 15:350-356.
2. WHO (World Health Organization) Worldwide prevalence of anaemia 1993-2005 2008, WHO (World Health Organization), Switzerland.
3. Foo L.H., Khor G.L., Tee E.S., et al. Iron status and dietary iron intake of adolescents from a rural community in Sabah, Malaysia. Asia Pac J Clin Nutr 2004, 13:48-55.
4. Assessing the iron status of population, report of a Joint World Health Organization/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at the population level 2004, WHO/CDC, Geneva, Switzerland.
5. South African Vitamin A Consultative Group Children aged 6-71months in South Africa, 1994: their anthropometric, vitamin A, iron and immunization coverage status 1995, South African Vitamin A Consultative Group, Isando. http://www.sahealthinfo.org.za.
6. Steyn NP, Mauner E, MacIntyre U, Swart R, Gericke G, Huskisson J, Dannhauser A, Vorster HH, Nesamvuni AE.In: Labadarios D. editor The National Food Consumption Survey (NFCS): children aged 1-9 years, South Africa, 1999. pretoria: department of health; 2000. Available from www.sahealthinfo.org/nutrition/nfcs/chapter4.
7. Labadarios D., Swart R., Maunder E., et al. Executive summary of the national food consumption survey-fortification baseline (NFCS-FB-I): South Africa (2005). S Afr J Clin Nutr 2008, 21(3 Suppl. 2):245-300.
8. Schrimshaw N.S. Iron deficiency. Sci Am 1991, 24-30.
9. Beard J.L. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001, 131:568S-579S.
10. Oppenheimer S.J. Iron and its relation to immunity and infectious disease. J Nutr 2001, 131:616S-633S.
11. Ryu S.Y., Jeong K.S., Kang B.N., et al. Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination. Anticancer Res 2000, 20:3331-3338.
12. Walker E.M., Walker S.M. Effects of iron overload on the immune system. Ann Clin Lab Sci 2000, 30:354-365.
13. Kulapongs P., Vithayasai V., Suskind R., et al. Cell-mediated immunity and phagocytosis and killing function in children with severe iron-deficiency anemia. Lancet 1974, 2:689-691.
14. Bhaskaram C., Reddy V. Cell-mediated immunity in iron and vitamin deficient children. Br Med J 1975, 3:522.
15. Macdougall L.G., Anderson R., McNab G.M., et al. The immune response in iron-deficient children: impaired cellular defense mechanisms with altered humoral components. J Pediatr 1975, 86:833-843.
16. Walter T., Arredondo S., Arévalo M., et al. Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants. Am J Clin Nutr 1986, 44:877-882.
17. Dallman P.R. Iron deficiency and the immune response. Am J Clin Nutr 1987, 46:329-334.
18. Thibault H., Galan P., Selz F., et al. The immune response in iron-deficient young children: effect of iron supplementation on cell-mediated immunity. Eur J Pediatr 1993, 152:120-124.
19. Ahluwalia N., Sun J., Krause D., et al. Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr 2004, 79:516-521.
20. Thurnham D.I., McCabe L.D., Haldar S., et al. Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr 2010, 92:546-555.
21. Kasdan T.S. Medical nutrition therapy for anemia. Krause's food, nutrition and diet therapy 2000, 781-800. WB Saunders, London. 10th ed. L.K. Mahan, S. Escott-Stump (Eds.).
22. Gopane R.E., Pisa P.T., Vorster H.H., et al. Relationships of alcohol intake with biological health outcomes in an African population in transition: the Transition and Health during Urbanisation in South Africa (THUSA) study. S Afr J Clin Nutr 2010, 23(2 Suppl. 1):S16-S21.
23. Ferrari M., Mistura L., Patterson E., et al. Evaluation of iron status in European adolescents through biochemical iron indicators: the HELENA study. Eur J Clin Nutr 2011, 65:340-349.
24. Chandra R.K. Reduced bactericidal capacity of polymorphs in iron deficiency. Arch Dis Child 1973, 48:864-866.
25. Krause A.M., Mastro G., Handte H., et al. Immune function did not decline with aging in apparently healthy well-nourished women. Mech Ageing Dev 1999, 112:43-57.
26. Lesourd B.M. Nutrition: a major factor influencing immunity in the elderly. J Nutr Health Aging 2004, 8:28-37.
27. Kemp J.D. The role of iron binding proteins in lymphocyte physiology and pathology. J Clin Immunol 1993, 13:81-92.
28. Hershko C. Iron and infection. Iron Nutr Health Dis 1996, 22:231-238.
29. Galan P., Thibault H., Preziosi P., et al. Interleukin 2 production in iron-deficient children. Biol Trace Elem Res 1992, 32:421-426.
30. Kochanowski B.A., Sherman A.R. Cellular growth in iron-deficient rats: effect of pre- and post-weanling iron repletion. J Nutr 1985, 115:279-287.
31. Verhoef H., West C.E., Ntedo P., et al. Serum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria. Am J Clin Nutr 2001, 74:767-775.
32. Wieringa F.T., Dijkhuizen M.A., West C.E., et al. Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr 2002, 132:3061-3066.
33. Abraham K., Muller C., Gruters A., et al. Minimal inflammation, acute phase response and avoidance of misclassification of vitamin A and iron status in infants-importance of a high-sensitivity C-reactive protein (CRP) assay. Int J Vitam Nutr Res 2003, 73:423-430.
34. Casas J.P., Shah T., Hingorani A.D., et al. C-reactive protein and coronary heart disease: a critical review. J Intern Med 2008, 264:295-314.
35. Yanoff L.B., Serbring N.G., Mchugh T., et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J obes 2007, 31:1412-1417.
36. Vega G.L. Obesity and the metabolic syndrome. Minerva Endocrinol 2004, 29:47-54.
37. Murray M.J., Murray A.B., Murray M.B., et al. The adverse effect of iron repletion on the course of certain infections. BMJ 1978, 2:1113-1115.
38. Oppenheimer S.J. Iron and its relation to immunity and infectious disease. J Nutr 2001, 131:616S-635S.
39. Chwang L., Soemantri A.G., Pollitt E. Iron supplementation and physical growth of rural Indonesian children. Am J Clin Nutr 1988, 47:496-501.
40. Pollitt E., Hathirat P., Kotchabhakdi N.J., et al. Iron deficiency and educational achievement in Thailand. Am J Clin Nutr 1989, 50(3 suppl):687-696.
41. Lawless J.W., Latham M.C., Stephenson L.S., et al. Iron supplementation improves appetite and growth in anemic Kenyan primary schoolchildren. J Nutr 1994, 124:645-654.
42. Beasley N.M., Tomkins A.M., Hall A., Lorri W., et al. The impact of weekly iron supplementation on the iron status and growth of adolescent girls in Tanzania. Trop Med Int Health 2000, 5:794-799.
43. Kochan I. The role of iron in bacterial infections with special consideration of host-tubercle interaction. Curr Top in Microbiol Immunol 1997, 60:1-30.
44. Kaduska M.B., Burkitt M.J., Xiang D.H., et al. Iron supplementation generates hydroxyl radical in vivo. An ESR spin trapping investigation. J Clin Invest 1995, 96:1653-1657.
45. Oppenheimer S.J., Gibson F.D., Macfarlane S.B., et al. Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Trans R Soc Trop Med Hyg 1986, 80:603-612.