Immune function is impaired in iron-deficient, homebound, older women

American Journal of Clinical Nutrition

Volumn 79, Issue 3, 2004, Pages 516-521

  Ahluwalia, Namanjeet ^a   Sun, Jianqin ^a   Krause, Deanna ^a   Mastro, Andrea ^a   Handte, Gordon ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Cell mediated immunity; Elderly women; Iron status; Oxidative burst capacity; Phagocytosis

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNE FUNCTION TEST; IRON DEFICIENCY; MAJOR CLINICAL STUDY; PREVALENCE; RESPIRATORY BURST; T LYMPHOCYTE; BLOOD; DRUG EFFECT; IMMUNOCOMPETENCE; IMMUNOLOGY; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; MIDDLE AGED; NUTRITIONAL DEFICIENCY; NUTRITIONAL STATUS; PHAGOCYTOSIS; PHYSIOLOGY;

CONCANAVALIN A; IRON;

AGED; AGING; CONCANAVALIN A; DEFICIENCY DISEASES; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; IMMUNOCOMPETENCE; IRON; LYMPHOCYTE ACTIVATION; MIDDLE AGED; NUTRITIONAL STATUS; PHAGOCYTOSIS; T-LYMPHOCYTES;

EID: 1642268199     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/79.3.516     Document Type: Article

References (47)

1. Bhaskaram P. Micronutrient malnutrition, infection, and immunity: an overview. Nutr Rev 2002;60:S40-5.
2. Sherman AR. Zinc, copper, and iron nutriture and immunity. J Nutr 1992;50:367-71.
3. Goodwin JS. Decreased immunity and increased morbidity in the elderly. Nutr Rev 1995;53:S41-6.
4. Murasko DM, Weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasins age. Clin Exp Immunol 1987;70:440-8.
5. Mazari L, Lesourd BM. Nutritional influences on immune response in healthy aged persons. Mech Aging Dev 1998;104:25-40.
6. Suboticanec K, Stavljenic A, Bilic-Pesic L, et al. Nutritional status, grip strength, and immune function in institutionalized elderly. Int J Vitam Nutr Res 1989;59:20-8.
7. High KP. Micronutrient supplementation and immune function in the elderly. Clin Infect Dis 1999;28:717-22.
8. Bogden JD, Oleske JM, Lavenhar MA, et al. Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr 1988;48:655-63.
9. Han SN, Meydani SN. Antioxidants, cytokines, and influenza infection in aged mice and elderly humans. J Infect Dis 2000;182(suppl 1):S74-80.
10. Fulop T, Wagner JR, Khalil A, Weber J, Trottier L, Payette H. Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. J Gerontol 1999;54A:M59-64.
11. Ahluwalia N, Lammi-Keefe CJ, Bendel RB, Morse EE, Beard JL, Haley NR. Iron deficiency and anemia of chronic disease in elderly women: a discriminant analysis approach for differentiation. Am J Clin Nutr 1995;61:590-6.
12. Beard JL, Richards RE, Smiciklas-Wright H, Bernardo V, Kordish S. Iron nutrition in rural home bound elderly persons. J Nutr Elder 1996;15:3-15.
13. Thomas AJ, Bunker VW, Stansfield MF, Sodha N, Mullee MA, Clayton BE. Iron status of hospitalized and housebound elderly people: dietary intake, metabolic balances, haematological and biochemical indices. Q J Med 1989;70:175-84.
14. Chen LH, Cook-Newell ME. Anemia and iron status in the free-living and institutionalized elderly in Kentucky. Int J Vitam Nutr Res 1989;59:207-13.
15. Lipschitz DA, Mitchell CO, Steele RW, Milton KY. Nutritional evaluation and supplementation of elderly subjects participating in a "Meals on Wheels" program. JPEN J Parenter Enteral Nutr 1985;9:343-7.
16. Walter T, Arredondo S, Arévalo M, Stekel A. Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants. Am J Clin Nutr 1986;44:877-82.
17. Yetgin S, Altay C, Ciliv G, Laleli Y. Myeloperoxidase activity and bactericidal function of PMN in iron deficiency. Acta Haematol 1979;61:10-4.
18. Thibault H, Galan P, Selz F, et al. The immune response in iron-deficient young children: effect of iron supplementation on cell-mediated immunity. Eur J Pediatr 1993;152:120-4.
19. Kemahli AS, Babacan E, Cavdar AO. Cell mediated immune responses in children with iron deficiency and combined iron and zinc deficiency. Nutr Res 1988;8:129-36.
20. Chandra RK, Saraya AK. Impaired immunocompetence associated with iron deficiency. J Pediatr 1975;86:899-902.
21. Bhaskaram C, Reddy V. Cell-mediated immunity in iron and vitamin-deficient children. Br Med J 1975;3:522.
22. Macdougall LG, Anderson R, McNab GM, Katz J. The immune response in iron-deficient children: impaired cellular defense mechanisms with altered humoral components. J Pediatr 1975;86:833-43.
23. Kulapongs P, Vithayasai V, Suskind R, Olson RE. Cell-mediated immunity and phagocytosis and killing function in children with severe iron-deficiency anemia. Lancet 1974;2;689-91.
24. Swarup-Mitra S, Sinha AK. Cell-mediated immunity in nutritional anaemia. Indian J Med Res 1984;79:354-62.
25. Farthing MJG. Iron and immunity. Acta Pediatr Scand Suppl 1989;361:44-52.
26. Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr 1987;46:329-34.
27. Strauss RG. Iron deficiency, infections, and immune function: a reassessment. Am J Clin Nutr 1978;31:660-6.
28. Ligthart GJ, Corberand JX, Fournier C, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Aging Dev 1984;28:47-55.
29. Jacobs DS, DeMott WR, Oxley DK. Laboratory test handbook. 5th ed. Hudson, OH: Lexi-Comp Inc, 2001.
30. Beisel WR. Single nutrients and immunity. Am J Clin Nutr 1982;35:417-68.
31. Gross RL, Reid JVO, Newberne PM, Burgess B, Marston R, Hift W. Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. Am J Clin Nutr 1975;28:225-32.
32. MacCuish AC, Urbaniak SJ, Goldstone AH, Irvine WJ. PHA responsiveness and subpopulations of circulating lymphocytes in pernicious anemia. Blood 1974;44:849-55.
33. Thurnham DI. Micronutrients and immune function: some recent developments. J Clin Pathol 1997;50:887-91.
34. Carmel R. Pernicious anemia: the expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking. Arch Intern Med 1988;148:1712-4.
35. Hillman RS, Finch CA. Red cell manual. 7th ed. Philadelphia: FA Davis Co, 1996.
36. Milman N, Pederson NS, Visfeldt J. Serum ferritin in healthy Danes: relation to marrow haemosiderin iron stores. Dan Med Bull 1983;30:115-20.
37. Krause D, Mastro AM, Handle G, Smiciklas-Wright H, Miles MP, Ahluwalia N. Immune function did not decline with aging in apparently healthy, well-nourished women. Mech Aging Dev 1999;112:43-57.
38. Fletcher MA, Baron GC, Ashman MR, Fischl MA, Klimas NG. Use of whole blood methods in assessment of immune parameters in immunodeficiency states. Diagn Clin Immunol 1987;5:69-81.
39. Kuvibidila S, Kitchens D, Baliga BS. In vivo and in vitro iron deficiency reduces protein kinase C activity and translocation in murine splenic and purified T cells. J Cell Biochem 1999;74:468-78.
40. Bagchi K, Mohanram M, Reddy V. Humoral immune response in children with iron-deficiency anaemia. Br Med J 1980;280:1249-51.
41. Fletcher J, Mather J, Lewis MJ, Whiting G. Mouth lesions in iron-deficient anemia: relation to Candida albicans in saliva and to impairment of lymphocyte transformation. J Infect Dis 1975;131:44-50.
42. Santos PC, Falcão RP. Decreased lymphocyte subsets and K-cell activity in iron deficiency anemia. Acta Haematol 1990;84:118-21.
43. Sawitsky B, Kanter R, Sawitsky A. Lymphocyte response to phytomitogens in iron deficiency. Am J Med 1976;272:153-60.
44. Joynson DH, Jacobs A, Walker DM, Dolby AE. Defect of cell-mediated immunity in patients with iron-deficiency anemia. Lancet 1972;2:1058-9.
45. Chandra RK. Reduced bactericidal capacity of polymorphs in iron deficiency. Arch Dis Child 1973;48:864-6.
46. Srikantia SG, Siva Prasad J, Bhaskaram C, Krishnamachari KAVR. Anemia and immune response. Lancet 1976;1:1307-9.
47. De Silva A, Atukorala S, Weerasinghe I, Ahluwalia N. Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka. Am J Clin Nutr 2003;77:234-42.