CYP24A1 Exacerbated Activity during Diabetes Contributes to Kidney Tubular Apoptosis via Caspase-3 Increased Expression and Activation

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Tourigny, Alexandre ^a   Charbonneau, Frédrick ^a   Xing, Paul ^a   Boukrab, Rania ^a   Rousseau, Guy ^a   St Arnaud, René ^b   Brezniceanu, Marie Luise ^a  

^a Centre de Recherche Hopital Du Sacre Coeur de Montreal   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOCHROME P450; CYTOCHROME P450 CYP24A1; HYDROGEN PEROXIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; INTRACELLULAR SIGNALING; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MALE; NONHUMAN; PEROXIDATION; PHENOTYPE; PROTEIN EXPRESSION; SENESCENCE; VITAMIN METABOLISM;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; GLUCOSE; HUMANS; HYDROGEN PEROXIDE; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDANTS; RECEPTORS, CALCITRIOL; RECEPTORS, LEPTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEROID HYDROXYLASES; UP-REGULATION;

EID: 84868291381     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048652     Document Type: Article

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