Incident isolated 1,25(OH) 2D 3 deficiency is more common than 25(OH)D deficiency in CKD

Journal of Nephrology

Volumn 25, Issue 2, 2012, Pages 204-210

  Levin, Adeera ^a,b   le Barbier, Melina ^a,b   Er, Lee ^a,b   Andress, Dennis ^c   Sigrist, Mhairi K ^a   Djurdjev, Ognjenka ^a,b  

^a BC Provincial Renal Agency   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ABBOTT LABORATORIES   (United States)

Author keywords

1,25(OH) 2D 3; 25(OH)D; Chronic kidney disease; Deficiencies

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCITRIOL; EPIDERMAL GROWTH FACTOR RECEPTOR;

AGED; ARTICLE; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; INCIDENCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

AGED; CALCITRIOL; CHRONIC DISEASE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY DISEASES; LOGISTIC MODELS; MALE; MIDDLE AGED; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84863311916     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2011.8429     Document Type: Article

References (14)

1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.
2. Johal M, Levin A. Vitamin D and parathyroid hormone in general populations: understandings in 2009 and applications to chronic kidney disease. Clin J Am Soc Nephrol. 2009;4:1508-1514.
3. Andress DL. Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation. Kidney Int. 2006;69:33-43.
4. Jean G, Terrat JC, Vanel T, et al. Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers. Nephrol Dial Transplant. 2008;23:3670-3676.
5. Papapoulos SE, vd Berg H, Frölich M, Valentijn RM. Circulating 1,25-dihydroxycholecalciferol after intravenous injections of 1 alpha-hydroxycholecalciferol in patients on regular haemodialysis. Nephrol Dial Transplant. 1988;3:647-650.
6. Lechner D, Kállay E, Cross HS. 1Alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. Mol Cell Endocrinol. 2007;263:55-64.
7. Seifert M, Tilgen W, Reichrath J. Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro. Anticancer Res. 2009;29:3659-3667.
8. Oksa A, Spustová V, Krivosíková Z, et al. Effects of longterm cholecalciferol supplementation on mineral metabolism and calciotropic hormones in chronic kidney disease. Kidney Blood Press Res. 2008;31:322-329.
9. Levin A, Bakris GL, Molitch M, et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 2007;71:31-38.
10. Stubbs JR, Idiculla A, Slusser J, Menard R, Quarles LD. Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD. J Am Soc Nephrol. 2010;21:353-361.
11. Gutierrez O, Isakova T, Rhee E, et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol. 2005;16:2205-2215.
12. Rucker D, Tonelli M, Coles MG, Yoo S, Young K, McMahon AW. Vitamin D insufficiency and treatment with oral vitamin D3 in northern-dwelling patients with chronic kidney disease. J Nephrol. 2009;22:75-82.
13. Chandra P, Binongo JN, Ziegler TR, et al. Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study. Endocr Pract. 2008;14:10-17.
14. Ravani P, Malberti F, Tripepi G, et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 2009;75:88-95.