CCR7-expressing B16 melanoma cells downregulate interferon-γ-mediated inflammation and increase lymphangiogenesis in the tumor microenvironment

Oncogenesis

Volumn 1, Issue 5, 2012, Pages

  Takekoshi, T ^a   Fang, L ^b   Paragh, G ^a   Hwang, S T ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CCR7; IFN g lymphangiogenesis; melanoma

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MONOCLONAL ANTIBODY; PODOPLANIN; RANTES; SECONDARY LYMPHOID TISSUE CHEMOKINE; STAT1 PROTEIN; VASCULOTROPIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CELL COUNT; CELL INVASION; CELL SUSPENSION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FOOT PAD; GENE EXPRESSION; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOPENIA; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MELANOMA B16; MELANOMA CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR VOLUME; UPREGULATION;

MURINAE;

EID: 84868289630     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2012.9     Document Type: Article

References (24)

1. Fang L, Hwang ST. Roles of CCR7 in Cancer Biology. In: Fulton AM (ed.) Chemokine Receptors in Cancer. Humana Press: New York, 2009; pp 93-108.
2. Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002; 62: 2937-2941. (Pubitemid 34525782)
3. Wiley HE, Gonzalez EB, Maki W, Wu MT, Hwang ST. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 2001; 93: 1638-1643. (Pubitemid 33094871)
4. Fang L, Lee VC, Cha E, Zhang H, Hwang ST. CCR7 regulates B16 murine melanoma cell tumorigenesis in skin. J Leukoc Biol 2008; 84: 965-972.
5. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci USA 1998; 95: 258-263. (Pubitemid 28103941)
6. Saeki H, Moore AM, Brown MJ, Hwang ST. Cutting edge: secondary lymphoidtissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol 1999; 162: 2472-2475. (Pubitemid 29309263)
7. Kriehuber E, Breiteneder-Geleff S, Groeger M, Soleiman A, Schoppmann SF, Stingl G et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med 2001; 194: 797-808. (Pubitemid 32983015)
8. Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7: 192-198. (Pubitemid 32148486)
9. Sadasivan B, Lehner PJ, Ortmann B, Spies T, Cresswell P. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity 1996; 5: 103-114. (Pubitemid 26301087)
10. Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8 + T cells. Cell 1992; 71: 1205-1214. (Pubitemid 23016554)
11. Ramadori G, Mitsch A, Rieder H, Meyer zum Buschenfelde KH. Alpha-and gammainterferon (IFN alpha, IFN gamma) but not interleukin-1 (IL-1) modulate synthesis and secretion of beta 2-microglobulin by hepatocytes. Eur J Clin Invest 1988; 18: 343-351.
12. Breiteneder-Geleff S, Soleiman A, Kowalski H, Horvat R, Amann G, Kriehuber E et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999; 154: 385-394. (Pubitemid 29094089)
13. Goydos JS, Gorski DH. Vascular endothelial growth factor C mRNA expression correlates with stage of progression in patients with melanoma. Clin Cancer Res 2003; 9: 5962-5967. (Pubitemid 38018082)
14. Issa A, Le TX, Shoushtari AN, Shields JD, Swartz MA. Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. Cancer Res 2009; 69: 349-357.
15. Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy Jr RL, Shows TB et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics 1994; 23: 643-650. (Pubitemid 24338652)
16. Bedogni B, Powell MB. Hypoxia, melanocytes and melanoma-survival and tumor development in the permissive microenvironment of the skin. Pigment Cell Melanoma Res 2009; 22: 166-174.
17. Zhu N, Lalla R, Eves P, Brown TL, King A, Kemp EH et al. Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone. Br J Cancer 2004; 90: 1457-1463. (Pubitemid 38586276)
18. Kakinuma T, Hwang ST. Chemokines chemokine receptors, and cancer metastasis. J Leukoc Biol 2006; 79: 639-651. (Pubitemid 44835596)
19. Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 973-981.
20. Dadras SS, Lange-Asschenfeldt B, Velasco P, Nguyen L, Vora A, Muzikansky A et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 2005; 18: 1232-1242. (Pubitemid 43079923)
21. Massi D, Puig S, Franchi A, Malvehy J, Vidal-Sicart S, Gonzalez-Cao M et al. Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study. J Clin Pathol 2006; 59: 166-173. (Pubitemid 43235582)
22. Dadras SS, Paul T, Bertoncini J, Brown LF, Muzikansky A, Jackson DG et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 2003; 162: 1951-1960. (Pubitemid 36613052)
23. Shields JD, Emmett MS, Dunn DB, Joory KD, Sage LM, Rigby H et al. Chemokinemediated migration of melanoma cells towards lymphatics-a mechanism contributing to metastasis. Oncogene 2007; 26: 2997-3005. (Pubitemid 46733648)
24. Yamazaki F, Okamoto H, Matsumura Y, Tanaka K, Kunisada T, Horio T. Development of a new mouse model (xeroderma pigmentosum a-deficient, stem cell factor-transgenic) of ultraviolet B-induced melanoma. J Invest Dermatol 2005; 125: 521-525.