TEI-A00114: A new vitamin D3 analogue that inhibits neutrophil recruitment in an acute lung injury hamster model while showing reduced hypercalcemic activity

Steroids

Volumn 77, Issue 14, 2012, Pages 1535-1542

  Takano, Yasuhiro ^a,b   Mitsuhashi, Hiroaki ^a   Ishizuka, Seiichi ^a   Takahashi, Katsushi ^a   Chokki, Manabu ^a   Takenouchi, Kazuya ^a   Gao, Qingzhi ^a   Tanaka, Hiroko ^a   Hazato, Atsushi ^a   Tabe, Masayasu ^a   Furuya, Minoru ^a   Manabe, Kenji ^a   Ueno, Koichi ^b  

^a TEIJIN LTD   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Acute lung injury; Calcemic action; IL 8; Neutrophils; TEI A00114; Vitamin D3 analogues

Indexed keywords

(2 ETHYL CYCLOPENTANONE 5 YLIDENE)METHYL 9,10 SECOPREGNA 5,7,10(19) TRIENE 1,3 DIOL; (2 HYDROXY 2 METHYL CYCLOPENTANONE 5 YLIDENE)METHYL 9,10 SECOPREGNA 5,7,10(19) TRIENE 1,3 DIOL; (2 HYDROXY 2 METHYLCYCLOHEXANONE 6 YLIDENE)METHYL 9,10 SECOPREGNA 5,7,10(19) TRIENE 1,3 DIOL; (2 METHYL CYCLOPENTANONE 5 YLIDENE)METHYL 9,10 SECOPREGNA 5,7,10(19) TRIENE 1,3 DIOL; 25 HYDROXYVITAMIN D; 26 DIMETHYLAMINO 9,10 SECOCHOLESTA 5,7,10(19) TRIENE 1,3,25 TRIOL 26 ONE; 26 METHYL 9,10 SECOCHOLESTA 5,7,10(19) TRIENE 1,3, 25 TRIOL 26 ONE; CALCIUM; COLECALCIFEROL DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 8; TEI A00114; TEI A00359; TEI B00022; TEI B00377; TEI B00868; TEI B00869; TEI C00188; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CALCIUM BLOOD LEVEL; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; HAMSTER; HYPERCALCEMIA; IN VITRO STUDY; MONOCYTE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN BINDING;

ACUTE LUNG INJURY; ANIMALS; CALCITRIOL; CALCIUM; CHOLECALCIFEROL; CRICETINAE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; MALE; NEUTROPHIL INFILTRATION; RATS; RATS, SPRAGUE-DAWLEY;

CRICETINAE;

EID: 84868254930     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.09.008     Document Type: Article

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