5-aza-CdR induces the demethylation of Syk promoter in nasopharyngeal carcinoma cell

Gene

Volumn 511, Issue 2, 2012, Pages 224-226

  Jin, Qiaozhi ^a   Liu, Chibo ^a   Yan, Chong ^a   Tao, Baohong ^a   Li, Zhihai ^a   Cai, Zhiyi ^a  

^a TAIZHOU MUNICIPAL HOSPITAL   (China)

Author keywords

5 aza CdR; Demethylation; Nasopharyngeal carcinoma; Syk

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; MESSENGER RNA; PROTEIN KINASE SYK;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DRUG SENSITIVITY; EPITHELIUM CELL; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA METHYLATION; DNA PRIMERS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NASOPHARYNGEAL NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84868211574     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.09.053     Document Type: Article

References (12)

1. Bailet O., et al. Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. Cancer Res. 2009, 69:2748-2756.
2. Cui M., Wen Z., Chen J., Yang Z., Zhang H. 5-Aza-2'-deoxycytidine is a potent inhibitor of DNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation of hMLH1. Med. Oncol. 2010, 27:278-285.
3. Dong S.W., et al. Research on the reactivation of Syk expression caused by the inhibition of DNA promoter methylation in the lung cancer. Neoplasma 2011, 58:89-95.
4. Feng B.J., et al. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat. Genet. 2002, 31:395-399.
5. Ma L., et al. The relationship between methylation of the Syk gene in the promoter region and the genesis of lung cancer. Clin. Lab. 2010, 56:407-416.
6. Momparler R.L., Eliopoulos N., Ayoub J. Evaluation of an inhibitor of DNA methylation, 5-aza-2'-deoxycytidine, for the treatment of lung cancer and the future role of gene therapy. Adv. Exp. Med. Biol. 2000, 465:433-446.
7. Nakashima H., et al. Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer. Cancer Lett. 2006, 236:89-94.
8. Ogane S., Onda T., Takano N., Yajima T., Uchiyama T., Shibahara T. Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma. Int. J. Cancer 2009, 124:2651-2657.
9. Xiong W., et al. A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res. 2004, 64:1972-1974.
10. Yu M.C., Yuan J.M. Epidemiology of nasopharyngeal carcinoma. Semin. Cancer Biol. 2002, 12:421-429.
11. Zhang X., Shrikhande U., Alicie B.M., Zhou Q., Geahlen R.L. Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol. Cancer Res. 2009, 7:634-644.
12. Zhao S., Sun G., Tony P.W., Ma D., Zhao C. Expression and methylation status of the Syk gene in cervical carcinoma. Arch. Gynecol. Obstet. 2011, 283:1113-1119.