Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin

Journal of Ethnopharmacology

Volumn 144, Issue 2, 2012, Pages 362-370

  Barcellona, Carolina Serra ^a   Cabrera, Wilfredo Marcelino ^a   Honoré, Stella Maris ^a   Mercado, María Inés ^a   Sánchez, Sara Serafina ^a   Genta, Susana Beatriz ^a  

^a UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

Author keywords

Acute and subchronic toxicity; Enhydrin; In vitro toxicity; Smallanthus sonchifolius leaves; Yacon

Indexed keywords

ENHYDRIN; LACTONE; PLANT EXTRACT; SMALLANTHUS SONCHIFOLIUS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FOOD INTAKE; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; MORTALITY; NONHUMAN; ORGAN WEIGHT; PHYTOCHEMISTRY; PLANT LEAF; RAT; RISK ASSESSMENT; SMALLANTHUS SONCHIFOLIUS;

ANIMALS; ASTERACEAE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; FEMALE; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; LACTONES; MALE; PLANT EXTRACTS; PLANT LEAVES; RATS, WISTAR; SESQUITERPENES; TOXICITY TESTS, ACUTE; TOXICITY TESTS, SUBCHRONIC; VERO CELLS;

ANIMALIA; POLYMNIA SONCHIFOLIA; RATTUS; RATTUS NORVEGICUS; SMALLANTHUS SONCHIFOLIUS;

EID: 84868204687     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.09.021     Document Type: Article

References (28)

1. G.V. Alexeeff, R. Broadwin, J. Liaw, and S.V. Dawson Characterization of the LOAEL-to-NOAEL uncertainty factor for mild adverse effects from acute inhalation exposures Regulatory Toxicology and Pharmacology 36 2002 96 105
2. M.J. Aybar, A.N. Sánchez Riera, A. Grau, and S.S. Sánchez Hypoglycemic effect of the water extract of Smallanthus sonchifolius (yacón) leaves in normal and diabetic rats Journal of Ethnopharmacology 74 2001 125 132
3. R.B. de Oliveira, D.A. de Paula, B.A. Rocha, J.J. Franco, L. Gobbo-Neto, S.A. Uyemura, W.F. dos Santos, and F.B. Da Costa Renal toxicity caused by oral use of medicinal plants: the yacon example Journal of Ethnopharmacology 133 2011 434 441
4. D.Q. Dou, F. Tian, Y.K. Qiu, Z. Xiang, B.X. Xu, T.G. Kang, and F. Dong Studies on chemical constituents of the leaves of Smallantus sonchifolius (yacon): structures of two new diterpenes Natural Product Research 24 1 2010 40 47
5. M.J. Fernandes, C. Limas, M.H. Rossi, E. Gonçales, and I. Simoni Cytotoxicity of subfractions and compounds from Polymnia sonchifolia Brazilian Journal of Microbiology 36 2005 338 341
6. R. Filip, P. López, G. Giberti, J. Coussio, and G. Ferraro Phenolic compounds in seven South American Ilex species Fitoterapia 72 7 2001 774 778
7. T.M. Fliedner, H. Heit, and G. Pabst Chapter 12: Evaluation and Prediction of Chemical Toxicity Using Haematopoietic Cell. Renewal Systems P. Bourdeau, Short-Term Toxicity Tests for Non-Genotoxic Effects. SCOPE. 1990 John Wiley & Sons Ltd. 177 192
8. S.B. Genta, W.M. Cabrera, M.I. Mercado, A. Grau, C.A. Catalan, and S.S. Sanchez Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: constituents of the most active fractions Chemico-Biological Interactions 185 2010 143 152
9. Z.D. Goodman Drug hepatotoxicity Clinics in Liver Disease 6 2 2002 381 397
10. A. Grau, and J. Rea Yacon Smallanthus sonchifolius M. Hermann, Heller Andean Root and Tubers: Ahipa, Arracacha, Maca and Yacon 1997 IPGRI Rome 199 240 Available from
11. S.M. Honoré, W.M. Cabrera, S.B. Genta, and S.S. Sánchez Protective effect of yacon leaves decoction against early nephropathy in experimental diabetic rats Food and Chemical Toxicology 50 2012 1704 1715
12. S.S. Hong, S.A. Lee, X.H. Han, M.H. Lee, J.S. Hwang, J.S. Park, K.W. Oh, K. Han, M.K. Lee, H. Lee, W. Kim, D. Lee, and B.Y. Hwang Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production Chemical & Pharmaceutical Bulletin 56 2008 199 202
13. H. Joung, D.Y. Kwon, J.G. Choi, D.Y. Shin, S.S. Chun, Y.B. Yu, and D.W. Shin Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity Journal of Natural Medicines 64 2 2010 212 215
14. Kawashima, S.; Sakato, M.; Terada, S.; Koide, Y.; Tanaka, M.; Ko, M.; 2001. Anti-diabetic agents containing lactones. Jpn Kokai Tokkyo Koho, Patent no. JP 2001247461.
15. F. Lin, M. Hasegawa, and O. Kodama Purification and identification of antimicrobial sesquiterpene lactones from yacon (Smallanthus sonchifolius) leaves Bioscience, Biotechnology and Biochemistry 67 2003 2154 2159
16. N. Ogose, M. Hirochi, T. Ebata, and Y. Katsumata Reproduction study in rats treated orally with yacon extracts Yakuri to Chiryo 37 6 2009 511 519
17. M.S. Paller Drug-induced nephropathies Medical Clinics of North America 74 4 1990 909 917
18. M.F.Y Rosidah, A. Sadikun, M. Ahmad, A.G. Akowuah, and M.Z. Asmawi Toxicology evaluation of standardized methanol extract of Gynura procumbens Journal of Ethnopharmacology 123 2009 244 249
19. K. Schorr, and F.B. Da Costa Quantitative determination of enhydrin in leaf rinse extracts and in glandular trichomes of Smallanthus sonchifolius (Asteraceae) by reversed-phase high-performance liquid chromatography Phytochemical Analysis 16 3 2005 161 165
20. T.J. Scmidt Toxic activities of sesquiterpene lactones: structural and biochemical aspects Current Organic Chemistry 3 6 1999 577 608
21. S.S. Singh Preclinical pharmacokinetics: an approach towards safe and efficacious drugs Current Drug Metabolism 7 2 2006 165 182 (Review)
22. D. Siriwan, T. Naruse, and H. Tamura Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells Fitoterapia 82 7 2011 1093 1101
23. P. Tamborini, H. Sigg, and G. Zbinden Acute toxicity testing in the nonlethal dose range: a new approach Regulatory Toxicology and Pharmacology 12 1 1990 69 87
24. S. Teo, D. Stirling, S. Thomas, A. Hoberman, A. Kiorpes, and V. Khetani A 90-days oral gavage toxicity study of d-methylphenidate and d, l-methylphenidate in Sprague-Dawley rats Toxicology 79 2002 183 196
25. K. Valentová, L. Cvak, A. Muck, J. Ulrichova, and V. Simanek Antioxidant activity of extracts from the leaves of Smallanthus sonchifolius European Journal of Nutrition 42 1 2003 61 66
26. K. Valentová, F. Sersen, and J. Ulrichová Radical scavenging and antilipoperoxidative activities of Smallanthus sonchifolius leaf extracts Journal of Agricultural and Food Chemistry 53 2005 5577 5582
27. K. Valentová, and J. Ulrichová Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc Czech Republic 147 2 2003 119 130 Review)
28. W.M. Westerink, and W.G. Schoonen. Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells Toxicology In Vitro 21 8 2007 1592 1602