Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL)

Breast Cancer Research and Treatment

Volumn 134, Issue 1, 2012, Pages 419-428

  Neugut, Alfred I ^a,b,i   Hillyer, Grace Clarke ^a   Kushi, Lawrence H ^c   Lamerato, Lois ^d   Leoce, Nicole ^b   Nathanson, S David ^d   Ambrosone, Christine B ^e   Bovbjerg, Dana H ^f   Mandelblatt, Jeanne S ^g   Magai, Carol ^h   Tsai, Wei Yann ^a,b   Jacobson, Judith S ^a,b   Hershman, Dawn L ^a,b  

^a Columbia University ^*  (United States)

^b Kaiser Permanente of Northern California ^*  (United States)

^c DIVISION OF RESEARCH   (United States)

^d HENRY FORD HEALTH SYSTEM   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

^f UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^g GEORGETOWN UNIVERSITY   (United States)

^h LONG ISLAND UNIVERSITY   (United States)

ⁱ NewYork Presbyterian Hospital   (United States)

Author keywords

Adherence; Breast cancer; Decision making; Hormonal therapy; Initiation; Quality of care

Indexed keywords

ANTINEOPLASTIC AGENT; HORMONE RECEPTOR;

ADULT; ADVERSE DRUG REACTION; AGED; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; COHORT ANALYSIS; DEMOGRAPHY; DOCTOR PATIENT RELATION; DRUG EFFICACY; FEMALE; HISTOPATHOLOGY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; MEDICAL RECORD; PATIENT ATTITUDE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SELF REPORT; UNITED STATES;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; DECISION MAKING; FEMALE; HUMANS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASMS, HORMONE-DEPENDENT; PROSPECTIVE STUDIES; QUALITY OF HEALTH CARE; RECEPTORS, CELL SURFACE; REGRESSION ANALYSIS;

EID: 84863989435     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2066-9     Document Type: Article

References (48)

1. M Clarke R Collins S Darby, et al. 2005 Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials Lancet 366 9503 2087 2106 16360786 1:STN:280:DC%2BD2MnnsVSitA%3D%3D
2. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) 2005 Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 9472 1687 1717 10.1016/S0140-6736(05)66544-0
3. D Hershman R McBride JS Jacobson, et al. 2005 Racial disparities in treatment and survival among women with early stage breast cancer J Clin Oncol 23 27 6639 6646 16170171 10.1200/JCO.2005.12.633
4. GH Lyman DC Dale J Crawford 2003 Incidence and predictors of low dose-intensity in adjuvant breast cancer chemotherapy: a nationwide study of community practices J Clin Oncol 21 24 4524 4531 14673039 10.1200/JCO.2003.05. 002
5. AH Partridge PS Wang EP Winer J Avorn 2003 Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer J Clin Oncol 21 4 602 606 12586795 10.1200/JCO.2003.07.071 1:CAS:528:DC%2BD2cXpsVGrtbs%3D
6. NA Bickell MD McEvoy 2003 Physicians' reasons for failing to deliver effective breast cancer care: a framework for underuse Med Care 41 3 442 446 12618647
7. DL Hershman X Wang R McBride JS Jacobson VR Grann AI Neugut 2006 Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women Breast Cancer Res Treat 99 3 313 321 16583264 10.1007/s10549-006-9206-z 1:CAS:528:DC%2BD28XptVWqs7Y%3D
8. DL Hershman X Wang R McBride JS Jacobson VR Grann AI Neugut 2006 Delay in initiating adjuvant radiotherapy following breast conservation surgery and its impact on survival Int J Radiat Oncol Biol Phys 65 5 1353 1360 16765531 10.1016/j.ijrobp.2006.03.048
9. SA Fedewa EM Ward AK Stewart SB Edge 2010 Delays in adjuvant chemotherapy treatment among patients with breast cancer are more likely in African American and Hispanic populations: a national cohort study 2004-2006 J Clin Oncol 28 27 4135 4141 20697082 10.1200/JCO.2009.27.2427
10. RA Silliman E Guadagnoli AB Weitberg V Mor 1989 Age as a predictor of diagnostic and initial treatment intensity in newly diagnosed breast cancer patients J Gerontol 44 2 M46 M50 2921470 1:STN:280:DyaL1M7ls1amsw%3D%3D
11. DL Hershman LH Kushi T Shao, et al. 2010 Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early stage breast cancer patients J Clin Oncol 28 27 4120 4128 20585090 10.1200/JCO.2009.25.9655
12. VC Jordan 1980 Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model Eur J Cancer 16 2 239 251 6768559 10.1016/0014-2964(80)90156-5 1:CAS:528:DyaL3cXitV2gtbw%3D
13. M Baum AU Budzar J Cuzick, et al. 2002 Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial Lancet 359 9324 2131 2139 12090977 10.1016/S0140-6736(02)09088- 8 1:CAS:528:DC%2BD38XkslGhsLY%3D
14. RC Coombes E Hall LJ Gibson, et al. 2004 A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer N Engl J Med 350 11 1081 1092 15014181 10.1056/NEJMoa040331 1:CAS:528:DC%2BD2cXitV2qtbc%3D
15. PE Goss JN Ingle S Martino, et al. 2005 Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17 J Natl Cancer Inst 97 17 1262 1271 16145047 10.1093/jnci/dji250 1:CAS:528:DC%2BD2MXpvFKjsrY%3D
16. PE Goss JN Ingle S Martino, et al. 2003 A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early stage breast cancer N Engl J Med 349 19 1793 1802 14551341 10.1056/NEJMoa032312 1:CAS:528:DC%2BD3sXosl2gtbc%3D
17. A Howell J Cuzick M Baum, et al. 2005 Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer Lancet 365 9453 60 62 15639680 10.1016/S0140- 6736(04)17666-6 1:STN:280:DC%2BD2M%2FhsVartA%3D%3D
18. B Thurlimann A Keshaviah AS Coates, et al. 2005 A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer N Engl J Med 353 26 2747 2757 16382061 10.1056/NEJMoa052258
19. NA Bickell F LePar JJ Wang H Leventhal 2007 Lost opportunities: physicians' reasons and disparities in breast cancer treatment J Clin Oncol 25 18 2516 2521 17577028 10.1200/JCO.2006.09.5539
20. NA Bickell JJ Wang S Oluwole, et al. 2006 Missed opportunities: racial disparities in adjuvant breast cancer treatment J Clin Oncol 24 9 1357 1362 16549830 10.1200/JCO.2005.04.5799
21. G Kimmick R Anderson F Camacho M Bhosle W Hwang R Balkrishnan 2009 Adjuvant hormonal therapy use among insured, low-income women with breast cancer J Clin Oncol 27 21 3445 3451 19451445 10.1200/JCO.2008.19.2419
22. Pini T, Griggs J, Hamilton A, Katz S (2011) Patterns and correlates of adjuvant breast cancer endocrine therapy use. J Clin Oncol 29 (suppl; abstr 510)
23. Quinn V, Strauss J, Schottinger J, Cheetham C, Haque R (2011) When to intervene to increase use of adjuvant hormone therapy among with hormone-sensitive breast cancer. J Clin Oncol 29 (suppl; abstr 511)
24. S Demissie RA Silliman TL Lash 2001 Adjuvant tamoxifen: predictors of use, side effects, and discontinuation in older women J Clin Oncol 19 2 322 328 11208822 1:CAS:528:DC%2BD3MXhtVektrk%3D
25. DL Hershman T Shao LH Kushi, et al. 2011 Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer Breast Cancer Res Treat 126 2 529 537 20803066 10.1007/s10549-010-1132-4 1:CAS:528:DC%2BC3MXjtFSrtrw%3D
26. AK Fink J Gurwitz W Rakowski E Guadagnoli RA Silliman 2004 Patient beliefs and tamoxifen discontinuance in older women with estrogen receptor-positive breast cancer J Clin Oncol 22 16 3309 3315 15310774 10.1200/JCO.2004.11.064
27. Neugut AI, Clarke Hillyer G, Kushi LH et al (2012) The breast cancer quality of care study (B-QUAL): a multi-center study to determine causes for non-compliance with breast cancer adjuvant therapy. Breast J. doi: 10.1111/j.1524-4741.2012.01240.x
28. ME Charlson P Pompei KL Ales CR MacKenzie 1987 A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 5 373 383 3558716 10.1016/0021-9681(87)90171-8 1:STN:280:DyaL2s7ms1GnsQ%3D%3D
29. HA Llewellyn-Thomas MJ McGreal EC Thiel S Fine C Erlichman 1991 Patients' willingness to enter clinical trials: measuring the association with perceived benefit and preference for decision participation Soc Sci Med 32 1 35 42 2008619 10.1016/0277-9536(91)90124-U 1:STN:280:DyaK3M7otVOmuw%3D%3D
30. JS Mandelblatt VB Sheppard A Hurria, et al. 2010 Breast cancer adjuvant chemotherapy decisions in older women: the role of patient preference and interactions with physicians J Clin Oncol 28 19 3146 3153 20516438 10.1200/JCO.2009.24.3295
31. CD Sherbourne AL Stewart 1991 The MOS social support survey Soc Sci Med 32 6 705 714 2035047 10.1016/0277-9536(91)90150-B 1:STN:280:DyaK3M3ktVejtw%3D%3D
32. E Maunsell M Drolet N Ouhoummane J Robert 2005 Breast cancer survivors accurately reported key treatment and prognostic characteristics J Clin Epidemiol 58 4 364 369 15862722 10.1016/j.jclinepi.2004.09.005
33. K-A Phillips RL Milne S Buys, et al. 2005 Agreement between self-reported breast cancer treatment and medical records in a population-based breast cancer family registry J Clin Oncol 23 21 4679 4686 15851764 10.1200/JCO.2005.03.002
34. K Ruddy E Mayer A Partridge 2009 Patient adherence and persistence with oral anticancer treatment CA Cancer J Clin 59 1 56 66 19147869 10.3322/caac.20004
35. RJ Bell M Lijovic P Fradkin, et al. 2009 Lack of knowledge of hormone receptor status and use of endocrine therapy in invasive breast cancer J Women's Health 18 12 1975 1980 10.1089/jwh.2008.1351
36. NA Bickell J Weidmann K Fei JJ Lin H Leventhal 2009 Underuse of breast cancer adjuvant treatment: patient knowledge, beliefs, and medical mistrust J Clin Oncol 27 31 5160 5167 19770368 10.1200/JCO.2009.22.9773
37. L Osterberg T Blaschke 2005 Adherence to medication N Engl J Med 353 5 487 497 16079372 10.1056/NEJMra050100 1:CAS:528:DC%2BD2MXntVCisL0%3D
38. RC Maly B Leake RA Silliman 2004 Breast cancer treatment in older women: impact of the patient-physician interaction J Am Geriatr Soc 52 7 1138 1145 15209652 10.1111/j.1532-5415.2004.52312.x
39. G Elwyn A O'Connor D Stacey, et al. 2006 Developing a quality criteria framework for patient decision aids: online international Delphi consensus process Br Med J 333 7565 417 10.1136/bmj.38926.629329.AE
40. Sepucha KR, Fowler FJ Jr, Mulley AG Jr (2004) Policy support for patient-centered care: the need for measurable improvements in decision quality. Health Aff (Millwood) Suppl Variation:VAR54-62
41. LA Siminoff P Ravdin N Colabianchi CM Sturm 2000 Doctor-patient communication patterns in breast cancer adjuvant therapy discussions Health Expect 3 1 26 36 11281909 10.1046/j.1369-6513.2000.00074.x
42. EA Waters ND Weinstein GA Colditz K Emmons 2009 Explanations for side effect aversion in preventive medical treatment decisions Health Psychol 28 2 201 209 19290712 10.1037/a0013608
43. R Horne J Weinman 1999 Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness J Psychosom Res 47 6 555 567 10661603 10.1016/S0022-3999(99)00057-4 1:STN:280: DC%2BD3c7isFantw%3D%3D
44. N Iihara T Tsukamoto S Morita C Miyoshi K Takabatake Y Kurosaki 2004 Beliefs of chronically ill Japanese patients that lead to intentional non-adherence to medication J Clin Pharm Ther 29 5 417 424 15482384 10.1111/j.1365-2710.2004.00580.x 1:STN:280:DC%2BD2crht12gtg%3D%3D
45. R Heisey N Pimlott M Clemons S Cummings N Drummond 2006 Women's views on chemoprevention of breast cancer: qualitative study Can Fam Physician 52 624 625 17327893 1:STN:280:DC%2BD2s7jtFCrtQ%3D%3D
46. EA Grunfeld MS Hunter P Sikka S Mittal 2005 Adherence beliefs among breast cancer patients taking tamoxifen Patient Educ Couns 59 1 97 102 16198223 10.1016/j.pec.2004.10.005
47. TL Lash MP Fox JL Westrup AK Fink RA Silliman 2006 Adherence to tamoxifen over the five-year course Breast Cancer Res Treat 99 2 215 220 16541307 10.1007/s10549-006-9193-0
48. Livaudais JC, Hershman DL, Habel L et al (2012) Racial/ethnic differences in initiation of adjuvant hormonal therapy among women with hormone receptor-positive breast cancer. Breast Cancer Res Treat 131(2):607-617