Early discontinuation of tamoxifen intake in younger women with breast cancer: Is it time to rethink the way it is prescribed?

European Journal of Cancer

Volumn 48, Issue 13, 2012, Pages 1939-1946

  Huiart, Laetitia ^a,b,c   Bouhnik, Anne Déborah ^b,c   Rey, Dominique ^b,c,d   Tarpin, Carole ^a   Cluze, Camille ^b,c,d   Bendiane, Marc Karim ^b,c,d   Viens, Patrice ^a,e   Giorgi, Roch ^f,g  

^a INSTITUT PAOLI CALMETTES   (France)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d OBSERVATOIRE RÉGIONAL DE LA SANTÉ PROVENCE ALPES CÔTE D AZUR   (France)

^e AIX MARSEILLE UNIVERSITY   (France)

^f AIX MARSEILLE UNIV   (France)

^g TIMONE HOSPITAL   (France)

Author keywords

Adjuvant treatment; Breast cancer; Cohort; Compliance; Persistence; Pharmacoepidemiology; Tamoxifen

Indexed keywords

TAMOXIFEN;

ADULT; AGE DISTRIBUTION; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; COHORT ANALYSIS; CONTROLLED STUDY; DATA BASE; DISEASE ASSOCIATION; DRUG WITHDRAWAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; NATIONAL HEALTH INSURANCE; PREDICTION; PRESCRIPTION; PRIORITY JOURNAL; QUESTIONNAIRE; SELF REPORT; SOCIAL SUPPORT;

ADULT; AGE FACTORS; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; FEMALE; FRANCE; HUMANS; PATIENT COMPLIANCE; POPULATION SURVEILLANCE; PREMENOPAUSE; SOCIAL SUPPORT; TAMOXIFEN; TIME FACTORS;

EID: 84865146558     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2012.03.004     Document Type: Article

References (35)

1. Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365(9472):1687-1717.
2. S. Demissie, R.A. Silliman, and T.L. Lash Adjuvant tamoxifen: predictors of use, side effects, and discontinuation in older women J Clin Oncol 19 2 2001 322 328 (Pubitemid 32112842)
3. A.H. Partridge, P.S. Wang, E.P. Winer, and J. Avorn Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer J Clin Oncol 21 4 2003 602 606 (Pubitemid 46621892)
4. A.K. Fink, J. Gurwitz, W. Rakowski, E. Guadagnoli, and R.A. Silliman Patient beliefs and tamoxifen discontinuance in older women with estrogen receptor - positive breast cancer J Clin Oncol 22 16 2004 3309 3315 (Pubitemid 41103687)
5. T.L. Lash, M.P. Fox, J.L. Westrup, A.K. Fink, and R.A. Silliman Adherence to tamoxifen over the five-year course Breast Cancer Res Treat 99 2 2006 215 220 (Pubitemid 44268270)
6. T.I. Barron, R. Connolly, K. Bennett, J. Feely, and M.J. Kennedy Early discontinuation of tamoxifen: a lesson for oncologists Cancer 109 5 2007 832 839 (Pubitemid 46333524)
7. K.L. Kahn, E.C. Schneider, J.L. Malin, J.L. Adams, and A.M. Epstein Patient centered experiences in breast cancer: predicting long-term adherence to tamoxifen use Med Care 45 5 2007 431 439
8. C. Owusu, D.S. Buist, and T.S. Field Predictors of tamoxifen discontinuation among older women with estrogen receptor-positive breast cancer J Clin Oncol 26 4 2008 549 555 (Pubitemid 351264347)
9. C. McCowan, J. Shearer, and P.T. Donnan Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer Br J Cancer 99 11 2008 1763 1768
10. V. Ziller, M. Kalder, and U.S. Albert Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer Ann Oncol 20 3 2009 431 436
11. D.L. Hershman, L.H. Kushi, and T. Shao Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients J Clin Oncol 28 27 2010 4120 4128
12. Early Breast Cancer Trialists' Collaborative Group Tamoxifen for early breast cancer: an overview of the randomised trials Lancet 351 9114 1998 1451 1467
13. J.L. Gnerlich, A.D. Deshpande, and D.B. Jeffe Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease J Am Coll Surg 208 3 2009 341 347
14. M. Chung, H.R. Chang, K.I. Bland, and H.J. Wanebo Younger women with breast carcinoma have a poorer prognosis than older women Cancer 77 1 1996 97 103 (Pubitemid 26002742)
15. L.J. Fallowfield, S.K. Leaity, A. Howell, S. Benson, and D. Cella Assessment of quality of life in women undergoing hormonal therapy for breast cancer: validation of an endocrine symptom subscale for the FACT-B Breast Cancer Res Treat 55 2 1999 189 199 (Pubitemid 29389581)
16. K.J. Ruddy, S. Gelber, and E.S. Ginsburg Menopausal symptoms and fertility concerns in premenopausal breast cancer survivors: a comparison to age- and gravidity-matched controls Menopause 18 1 2011 105 108
17. P.A. Ganz, G.A. Greendale, L. Petersen, B. Kahn, and J.E. Bower Breast cancer in younger women: reproductive and late health effects of treatment J Clin Oncol 21 22 2003 4184 4193 (Pubitemid 46606187)
18. V. Mor, M. Malin, and S. Allen Age differences in the psychosocial problems encountered by breast cancer patients J Natl Cancer Inst Monogr 16 1994 191 197
19. K. Martin-Latry, and B. Begaud Pharmacoepidemiological research using French reimbursement databases: yes we can! Pharmacoepidemiol drug saf 19 3 2010 256 265
20. The WHOQOL Group Development of the World Health Organization WHOQOL-BREF quality of life assessment Psychol Med 28 3 1998 551 558
21. C. Baumann, M.L. Erpelding, S. Regat, J.F. Collin, and S. Briancon The WHOQOL-BREF questionnaire: French adult population norms for the physical health, psychological health and social relationship dimensions Rev Epidemiol Sante Publique 58 1 2010 33 39
22. R. Fuhrer, and S. Wessely The epidemiology of fatigue and depression: a French primary-care study Psychol Med 25 5 1995 895 905
23. S.E. Andrade, K.H. Kahler, F. Frech, and K.A. Chan Methods for evaluation of medication adherence and persistence using automated databases Pharmacoepidemiol Drug Saf 15 8 2006 565 574 [discussion 575-577] (Pubitemid 44336271)
24. J.A. Cramer, A. Roy, and A. Burrell Medication compliance and persistence. terminology and definitions Value Health 11 1 2008 44 47 (Pubitemid 351160875)
25. B. Fisher, J. Costantino, and C. Redmond A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors N Engl J Med 320 8 1989 479 484 (Pubitemid 19062522)
26. R.R. Love Prospects for antiestrogen chemoprevention of breast cancer J Natl Cancer Inst 82 1 1990 18 21 (Pubitemid 20020887)
27. D.M. Waterhouse, K.A. Calzone, C. Mele, and D.E. Brenner Adherence to oral tamoxifen: a comparison of patient self-report, pill counts, and microelectronic monitoring J Clin Oncol 11 6 1993 1189 1197 (Pubitemid 23163362)
28. A.H. Partridge, A. LaFountain, and E. Mayer Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer J Clin Oncol 26 4 2008 556 562 (Pubitemid 351264348)
29. L. Huiart, S. Dell'Aniello, and S. Suissa Use of tamoxifen and aromatase inhibitors in a large population-based cohort of women with breast cancer Br J Cancer 104 10 2011 1558 1563
30. L. Osterberg, and T. Blaschke Adherence to medication N Engl J Med 353 5 2005 487 497 (Pubitemid 41127293)
31. R.B. Haynes, E. Ackloo, N. Sahota, H.P. McDonald, and X. Yao Interventions for enhancing medication adherence Cochrane Database Syst Rev 2 2008 CD000011
32. B. Thewes, B. Meiser, and V.M. Duric What survival benefits do premenopausal patients with early breast cancer need to make endocrine therapy worthwhile? Lancet Oncol 6 8 2005 581 588 (Pubitemid 41051936)
33. M.C. Kirk, and C.A. Hudis Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer Clin Breast Cancer 2008 155 161 United States (Pubitemid 351655930)
34. C. Cluze, D. Rey, and L. Huiart Adjuvant endocrine therapy with tamoxifen in young women with breast cancer: determinants of interruptions vary over time Ann oncol 2011 [Epub ahead of print]
35. P.W. Choo, C.S. Rand, and T.S. Inui Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy Med care 37 9 1999 846 857