메뉴 건너뛰기




Volumn 4, Issue , 2011, Pages 209-215

Clinical utility of vandetanib in the treatment of patients with advanced medullary thyroid cancer

Author keywords

Medullary thyroid cancer; Vandetanib; ZD6474

Indexed keywords

CABOZANTINIB; PLACEBO; PROTEIN RET; PROTEIN TYROSINE KINASE INHIBITOR; VANDETANIB; VASCULOTROPIN RECEPTOR;

EID: 84868199576     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S17422     Document Type: Review
Times cited : (10)

References (35)
  • 1
    • 84873552390 scopus 로고    scopus 로고
    • Thyroid tumors
    • In: DeVita VT, Hellman S, Rosenberg SA, editors, Philadelphia, PA: Lippincott Williams & Wilkins
    • Carling T, Udelsman R. Thyroid tumors. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.
    • (2011) Cancer: Principles and Practice of Oncology
    • Carling, T.1    Udelsman, R.2
  • 2
    • 84924637584 scopus 로고
    • Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity
    • Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab. 1959; 19(1):152-161.
    • (1959) J Clin Endocrinol Metab , vol.19 , Issue.1 , pp. 152-161
    • Hazard, J.B.1    Hawk, W.A.2    Crile Jr., G.3
  • 4
    • 0001251788 scopus 로고
    • The association of pheochromocytoma with carcinoma of the thyroid gland
    • Sipple JH. The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med. 1961;31(1):163-166.
    • (1961) Am J Med , vol.31 , Issue.1 , pp. 163-166
    • Sipple, J.H.1
  • 5
    • 0014331669 scopus 로고
    • Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: Multiple endocrine neoplasia, type 2
    • Steiner AL, Goodman AD, Powers SR. Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism and Cushing's disease: multiple endocrine neoplasia, type 2. Medicine (Baltimore). 1968;47(5):371-409.
    • (1968) Medicine (Baltimore) , vol.47 , Issue.5 , pp. 371-409
    • Steiner, A.L.1    Goodman, A.D.2    Powers, S.R.3
  • 6
    • 58249095068 scopus 로고    scopus 로고
    • The genetic basis of hereditary medullary thyroid cancer: Clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy
    • Sakorafas GH, Friess H, Peros G. The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy. Endocr Relat Cancer. 2008;15(4):871-884.
    • (2008) Endocr Relat Cancer , vol.15 , Issue.4 , pp. 871-884
    • Sakorafas, G.H.1    Friess, H.2    Peros, G.3
  • 7
    • 85047682409 scopus 로고    scopus 로고
    • Guidelines for diagnosis and therapy of MEN type 1 and type 2
    • B Brandi ML, Gagel RF, Angeli A, et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab. 2001; 86(12):5658-5671.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.12 , pp. 5658-5671
    • B Brandi, M.L.1    Gagel, R.F.2    Angeli, A.3
  • 8
    • 0029916917 scopus 로고    scopus 로고
    • Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables
    • Dottorini ME, Assi A, Sironi M, Sangalli G, Spreafico G, Colombo L. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer. 1996;77(8):1556-1565.
    • (1996) Cancer , vol.77 , Issue.8 , pp. 1556-1565
    • Dottorini, M.E.1    Assi, A.2    Sironi, M.3    Sangalli, G.4    Spreafico, G.5    Colombo, L.6
  • 9
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: Demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman S, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer. 2006;107(9):2134-2142.
    • (2006) Cancer , vol.107 , Issue.9 , pp. 2134-2142
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 10
    • 0025322092 scopus 로고
    • Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study
    • Scherubl H, Raue F, Ziegler R. Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study. J Cancer Res Clin Oncol. 1990;116(1):21-23.
    • (1990) J Cancer Res Clin Oncol , vol.116 , Issue.1 , pp. 21-23
    • Scherubl, H.1    Raue, F.2    Ziegler, R.3
  • 11
    • 36549015772 scopus 로고    scopus 로고
    • Novel chemotherapy options for advanced thyroid tumors: Small molecules offer great hope
    • Deshpande HA, Gettinger SN, Sosa JA. Novel chemotherapy options for advanced thyroid tumors: small molecules offer great hope. Curr Opin Oncol. 2008;20(1):19-24.
    • (2008) Curr Opin Oncol , vol.20 , Issue.1 , pp. 19-24
    • Deshpande, H.A.1    Gettinger, S.N.2    Sosa, J.A.3
  • 12
    • 0013829212 scopus 로고
    • Familial amyloid-producing medullary thyroid carcinoma and pheochromocytoma. A distinct genetic entity
    • Schimke RN, Hartmann WH. Familial amyloid-producing medullary thyroid carcinoma and pheochromocytoma. A distinct genetic entity. Ann Intern Med. 1965;63(6):1027-1039.
    • (1965) Ann Intern Med , vol.63 , Issue.6 , pp. 1027-1039
    • Schimke, R.N.1    Hartmann, W.H.2
  • 13
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, RET, by DNA rearrangement
    • Takahashi M, Ritz J, Cooper GM. Activation of a novel human transforming gene, RET, by DNA rearrangement. Cell. 1985;42(2):581-588.
    • (1985) Cell , vol.42 , Issue.2 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 14
    • 0032894774 scopus 로고    scopus 로고
    • RET protooncogene in the development of human cancer
    • Eng C. RET protooncogene in the development of human cancer. J Clin Oncol. 1999;17(1):380-393.
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 380-393
    • Eng, C.1
  • 15
    • 77955298957 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma
    • Capp C, Wajner SM, Siqueira DR, Brasil BA, Meurer L, Maia AL. Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma. Thyroid. 2010;20(8):863-871.
    • (2010) Thyroid , vol.20 , Issue.8 , pp. 863-871
    • Capp, C.1    Wajner, S.M.2    Siqueira, D.R.3    Brasil, B.A.4    Meurer, L.5    Maia, A.L.6
  • 16
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-676.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 17
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002;62(16): 4645-4655.
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 18
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F, Vitagliano D, Guida T, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res. 2002;62(24):7284-7290.
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 19
    • 33846850223 scopus 로고    scopus 로고
    • Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
    • Herbst RS, Heymach JV, O'Reilly MS, Onn A, Ryan AJ. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs. 2007;16(2):239-249.
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.2 , pp. 239-249
    • Herbst, R.S.1    Heymach, J.V.2    O'Reilly, M.S.3    Onn, A.4    Ryan, A.J.5
  • 20
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol. 2005;16(8):1391-1397.
    • (2005) Ann Oncol , vol.16 , Issue.8 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3
  • 21
    • 33846844387 scopus 로고    scopus 로고
    • A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
    • Tamura T, Minami H, Yamada Y, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thorac Oncol. 2006;1(9):1002-1009.
    • (2006) J Thorac Oncol , vol.1 , Issue.9 , pp. 1002-1009
    • Tamura, T.1    Minami, H.2    Yamada, Y.3
  • 22
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA Jr, Gosnell JE, Gagel RF, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol. 2010;28(5):767-772.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 23
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab. 2010;95(6): 2664-2671.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 24
    • 78650408242 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic medullary thyroid cancer: A randomized double blind Phase III trial (ZETA) [abstract]
    • Abst 5503
    • Wells SA, Robinson BG, Gagel RF, et al. Vandetanib in locally advanced or metastatic medullary thyroid cancer: a randomized double blind Phase III trial (ZETA) [abstract]. J Clin Oncol. 2010;28(15 Suppl): Abst 5503.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 25
    • 84873544100 scopus 로고    scopus 로고
    • Vandetanib (ZD6474) tablets Oncologic Drugs Advisory Committee (ODAC) Meeting Briefing Document 02 December 2010. Available at, Accessed October 31, 2011
    • Vandetanib (ZD6474) tablets Oncologic Drugs Advisory Committee (ODAC) Meeting Briefing Document 02 December 2010. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/OncologicDrugsAdvisoryCommittee/UCM235092.pdf. Accessed October 31, 2011.
  • 26
    • 0023191605 scopus 로고
    • Chemotherapy of thyroid carcinoma
    • Ahuja S, Ernst H. Chemotherapy of thyroid carcinoma. J Endocrinol Invest. 1987;10(3):303-310.
    • (1987) J Endocrinol Invest , vol.10 , Issue.3 , pp. 303-310
    • Ahuja, S.1    Ernst, H.2
  • 27
    • 73949123850 scopus 로고    scopus 로고
    • Chemotherapy with paclitaxel and gemcitabine in progressive medullary and thyroid carcinoma of the follicular epithelium
    • Matuszczyk A, Petersenn S, Voigt W, et al. Chemotherapy with paclitaxel and gemcitabine in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res. 2010;42(1):61-64.
    • (2010) Horm Metab Res , vol.42 , Issue.1 , pp. 61-64
    • Matuszczyk, A.1    Petersenn, S.2    Voigt, W.3
  • 28
    • 33751052512 scopus 로고    scopus 로고
    • Capecitabine therapy for refractory metastatic thyroid carcinoma: A case series
    • Gilliam LK, Kohn AD, Lalani T, et al. Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. Thyroid. 2006;16(8): 801-810.
    • (2006) Thyroid , vol.16 , Issue.8 , pp. 801-810
    • Gilliam, L.K.1    Kohn, A.D.2    Lalani, T.3
  • 29
    • 78650377385 scopus 로고    scopus 로고
    • Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a phase I study of XL184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET [abstract]
    • Abst
    • Kurzrock R, Cohen EE, Sherman SI, et al. Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a phase I study of XL184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET [abstract]. J Clin Oncol. 2010;28(15 Suppl):Abst 5502.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 5502
    • Kurzrock, R.1    Cohen, E.E.2    Sherman, S.I.3
  • 30
    • 56849132326 scopus 로고    scopus 로고
    • A phase I study of XL184, a MET, VEGFR2, and RET kinase inhibitor, administered orally to patients (pts) with advanced malignancies including a subgroup of patients with medullary thyroid cancer (MTC) [abstract]
    • Abst
    • Salgia R, Sherman S, Hong DS, et al. A phase I study of XL184, a MET, VEGFR2, and RET kinase inhibitor, administered orally to patients (pts) with advanced malignancies including a subgroup of patients with medullary thyroid cancer (MTC) [abstract]. J Clin Oncol. 2008; 26 Suppl:Abst 3522.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 3522
    • Salgia, R.1    Sherman, S.2    Hong, D.S.3
  • 31
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol. 2009; 27(23):3794-3801.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 32
    • 79959333068 scopus 로고    scopus 로고
    • Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer
    • Deshpande HA, Gettinger S, Sosa JA. Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer. Core Evid. 2010;4:43-48.
    • (2010) Core Evid , vol.4 , pp. 43-48
    • Deshpande, H.A.1    Gettinger, S.2    Sosa, J.A.3
  • 33
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol. 2008;26(29):4708-4713.
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 34
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • Lam ET, Ringel MD, Kloos RT, et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol. 2010;28(14): 2323-2330.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 35
    • 78049462514 scopus 로고    scopus 로고
    • Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
    • Carr LL, Mankoff DA, Goulart BH, et al. Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res. 2010;16(21): 5260-5268.
    • (2010) Clin Cancer Res , vol.16 , Issue.21 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.A.2    Goulart, B.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.