Trans-caryophyllene, a natural sesquiterpene, causes tracheal smooth muscle relaxation through blockade of voltage-dependent CA 2+ channels

Molecules

Volumn 17, Issue 10, 2012, Pages 11965-11977

  Pinho Da Silva, Leidiane ^a,b   Mendes Maia, Paula Virgínia ^a,b   Do Nascimento Garcia Teófilo, Taylena Maria ^a   Barbosa, Roseli ^a   Ceccatto, Vania Marilande ^a   Coelho De Souza, Andrelina Noronha ^a   Cruz, Jader Santos ^b   Leal Cardoso, José Henrique ^a  

^a STATE UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Anti spasmodic; Rat tracheal smooth muscle; Trans caryophyllene; Voltage dependent Ca 2+ channels

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CARYOPHYLLENE; SESQUITERPENE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; MALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; PHYSIOLOGY; RAT; SMOOTH MUSCLE; TRACHEA;

ACETYLCHOLINE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; RATS; SESQUITERPENES; TRACHEA;

EID: 84868159299     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171011965     Document Type: Article

References (22)

1. Craveiro, A.A.; Fernandes, A.G.; Andrade, C.H.S.; Matos, F.J.A.; Alencar, J.W.; Machado, M.I.L. Óleos Essenciais de Plantas do Nordeste; UFC: Fortaleza, Brazil, 1981.
2. Leal-Cardoso, J.H.; Fonteles, M.C. Pharmacological effects of essential oils of plants of the northeast of Brazil. An. Acad. Bras. Cienc. 1999, 71, 207-213.
3. Evangelista, G.L.; Coelho-de-Souza, A.N.; Santos, C.F.; Leal-Cardoso, J.H.; Lopes, E.A.; dos Santos, M.V.; Lahlou, S.; Magalhães, P.J. Essential oil of Pterodon polygalaeflorus inhibits electromechanical coupling on rat isolated trachea. J. Ethnopharmacol. 2007, 109, 515-522.
4. Astani, A.; Reichling, J.; Schnitzler, P. Screening for Antiviral Activities of Isolated Compounds from Essential Oils. Evid. Based Complement Alternat. Med. 2011, doi:10.1093/ecam/nep187.
5. Chavan, M.J.; Wakte, P.S.; Shinde, D.B. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine 2010, 17, 149-151.
6. Gertsch, J. Anti-inflammatory cannabinoids in diet: Towards a better understanding of CB (2) receptor action? Commun. Integr. Biol. 2008, 1, 26-28.
7. Fernandes, E.S.; Passos, G.F.; Medeiros, R.; da Cunha, F.M.; Ferreira, J.; Campos, M.M.; Pianowski, L.F., Calixto, J.B. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur. J. Pharmacol. 2007, 569, 228-236.
8. Medeiros, R.; Passos, G.F.; Vitor, C.E.; Koepp, J.; Mazzuco, T.L.; Pianowski, L.F.; Campos, M.M.; Calixto, J.B. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br. J. Pharmacol. 2007, 151, 618-627.
9. Leonhardt, V.; Leal-Cardoso, J.H.; Lahlou, S.; Albuquerque, A.A.; Porto, R.S.; Celedônio, N.R.; Oliveira, A.C.; Pereira, R.F.; Silva, L.P.; Garcia-Teófilo, T.M.; et al. Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent beta-caryophyllene on rat isolated ileum. Fundam. Clin. Pharm. 2010, 24, 749-758.
10. 2+) regulation in airway smooth muscle contraction: Do the data contradict dogma? Am. J. Physiol. Lung Cell. Mol. Physiol. 2002, 282, 1161-1178.
11. Goldie, R.G.; Fernandes, L.B.; Farmer, S.G.; Hay, D.W. Airway epithelium-derived inhibitory factor. Trends Pharmacol. Sci. 1990, 11, 67-70.
12. Grafe, P.; Mayer, C.J.; Wood, J.D. Synaptic modulation of calcium-dependent potassium conductance in myenteric neurones in the guinea-pig. J. Physiol. 1980, 305, 235-248.
13. Janssen, L.J.; Hague, C.; Nana, R. Ionic mechanisms underlying electrical slow waves in canine airway smooth muscle. Am. J. Physiol. 1998, 275, 516-523.
14. Hille, B. Ion Channels of Excitable Membranes, 3rd ed.; Sinauer Associates: Sunderland, UK, 2001.
15. Murray, R.K.; Kotlikoff, M.I. Receptor-activated calcium influx in human airway smooth cells. J. Physiol. 1991, 435, 123-144.
16. Somlyo, A.V.; Bond, M.; Somlyo, A.P.; Scarpa, A. Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc. Natl. Acad. Sci. USA 1985, 82, 5231-5235.
17. Schmidt, D.; Rabe, K.F. The role of leukotrienes in the regulation of tone and responsiveness in isolated human airways. Am. J. Resp. Crit. Care. Med. 2000, 161, S62-S67.
18. Du, W.; McMahon, T.J.; Zhang, Z.S.; Stiber, J.A.; Meissner, G.; Eu, J.P. Excitation-contraction coupling in airway smooth muscle. J. Biol. Chem. 2006, 281, 31143-31151.
19. Coburn, R.F.; Baron, C.B. Coupling mechanisms in airway smooth muscle. Am. J. Physiol. Lung. Cell. Mol. Physiol. 1990, 258, L119-L133.
20. 2+ release in agonist-induced contractions in guinea-pig trachea. Am. J. Physiol. Lung. Cell. Mol. Physiol. 1994, 266, L620-L627.
21. Pinheiro, B.G.; Silva, A.S.B.; Souza, G.E.P.; Figueiredo, J.G.; Cunha, F.Q.; Lahlou, S.; da Silva, J.K.R.; Maia, J.G.S.; Sousa, P.J.C. Chemical composition, antinociceptive and anti-inflammatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud. J. Ethnopharm. 2011, 138, 479-486.
22. Cho, J.Y. Recent Advances in Mechanisms and Treatments of Airway Remodeling in Asthma: A Message from the Bench Side to the Clinic. Korean J. Int. Med. 2011, 26, 367-383.