Ageing and cardiorespiratory response to hypoxia

Journal of Physiology

Volumn 590, Issue 21, 2012, Pages 5461-5474

  Lhuissier, François J ^a,b   Canouï Poitrine, Florence ^c,d   Richalet, Jean Paul ^a,b  

^a UNIVERSITÉ PARIS 13   (France)

^b AVICENNE HOSPITAL   (France)

^c FACULTÉ DE MÉDECINE   (France)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ADOLESCENT; ADULT; AGED; AGING; AIR CONDITIONING; ARTICLE; CARDIAC RESPONSE; CARDIORESPIRATORY RESPONSE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENDURANCE TRAINING; EVOKED RESPONSE; EXERCISE; FATTY ACID DESATURATION; FEMALE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; PRIORITY JOURNAL; REST; SEX; TRAINING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ANOXIA; EXERCISE; FEMALE; HEART; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PULMONARY VENTILATION; YOUNG ADULT;

EID: 84868155230     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.238527     Document Type: Article

References (37)

1. Adamczyk W, Tafil-Klawe M, Chesy G, Klawe JJ, Szeliga-Wczysla M & Zlomanczuk P (2006). Effects of training on the ventilatory response to hypoxia. J Physiol Pharmacol 57, 7-14.
2. Ahmed M, Giesbrecht GG, Serrette C, Georgopoulos D & Anthonisen NR (1991). Ventilatory response to hypoxia in elderly humans. Respir Physiol 83, 343-351.
3. Chapman KR & Cherniack NS (1987). Aging effects on the interaction of hypercapnia and hypoxia as ventilatory stimuli. J Gerontol 42, 202-209.
4. Christou DD & Seals DR (2008). Decreased maximal heart rate with aging is related to reduced b-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. J Appl Physiol 105, 24-29.
5. Edwards BA, O'Driscoll DM, Ali A, Jordan AS, Trinder J & Malhotra A (2010). Aging and sleep: physiology and pathophysiology. Semin Respir Crit Care Med 31, 618-633.
6. Foster GE, McKenzie DC, Milsom WK & Sheel AW (2005). Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 567, 689-699.
7. Garcia-Rio F, Villamor A, Gomez-Mendieta A, Lores V, Rojo B, Ramirez T & Villamor J (2007). The progressive effects of ageing on chemosensitivity in healthy subjects. Respir Med 101, 2192-2198.
8. Green JS, Stanforth PR, Gagnon J, Leon AS, Rao DC, Skinner JS, Bouchard C, Rankinen T & Wilmore JH (2002). Menopause, estrogen, and training effects on exercise hemodynamics: the HERITAGE study. Med Sci Sports Exerc 34, 74-82.
9. Hannhart B, Pickett CK, Weil JV & Moore LG (1989). Influence of pregnancy on ventilatory and carotid body neural output responsiveness to hypoxia in cats. J Appl Physiol 67, 797-803.
10. Hawkins S & Wiswell R (2003). Rate and mechanism of maximal oxygen consumption decline with aging: implications for exercise training. Sports Med 33, 877-888.
11. Heath D (1991). The human carotid body in health and disease. J Pathol 164, 1-8.
12. Janssens JP, Pache JC & Nicod LP (1999). Physiological changes in respiratory function associated with ageing. Eur Respir J 13, 197-205.
13. Kronenberg RS & Drage CW (1973). Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 52, 1812-1819.
14. Lhuissier FJ, Brumm M, Ramier D & Richalet JP (2012). Ventilatory and cardiac responses to hypoxia at submaximal exercise are independent of altitude and exercise intensity. J Appl Physiol 112, 566-570.
15. McKenzie DC (2012). Respiratory physiology: adaptations to high-level exercise. Br J Sports Med 46, 381-384.
16. Mollard P, Woorons X, Letournel M, Lamberto C, Favret F, Pichon A, Beaudry M & Richalet JP (2007). Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes. Eur J Appl Physiol 100, 663-673.
17. Moore LG, McCullough RE & Weil JV (1987). Increased HVR in pregnancy: relationship to hormonal and metabolic changes. J Appl Physiol 62, 158-163.
18. Peterson DD, Pack AI, Silage DA & Fishman AP (1981). Effects of aging on ventilatory and occlusion pressure responses to hypoxia and hypercapnia. Am Rev Respir Dis 124, 387-391.
19. Pialoux V, Hanly PJ, Foster GE, Brugniaux JV, Beaudin AE, Hartmann SE, Pun M, Duggan CT & Poulin MJ (2009). Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans. Am J Respir Crit Care Med 180, 1002-1009.
20. Pokorski M & Antosiewicz J (2010). Alterations in the hypoxic ventilatory response with advancing age in awake rats. J Physiol Pharmacol 61, 227-232.
21. Pokorski M & Marczak M (2003). Ventilatory response to hypoxia in elderly women. Ann Hum Biol 30, 53-64.
22. Pokorski M, Walski M, Dymecka A & Marczak M (2004). The aging carotid body. J Physiol Pharmacol 55, 107-113.
23. Richalet JP, Larmignat P, Poitrine E, Letournel M & Canoui-Poitrine F (2012). Physiological risk factors for severe high-altitude illness: a prospective cohort study. Am J Respir Crit Care Med 185, 192-198.
24. Sajkov D, Neill A, Saunders NA & McEvoy RD (1997). Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women. J Appl Physiol 83, 599-607.
25. Schoene RB (1982). Control of ventilation in climbers to extreme altitude. J Appl Physiol 53, 886-890.
26. Schoene RB, Robertson HT, Pierson DJ & Peterson AP (1981). Respiratory drives and exercise in menstrual cycles of athletic and nonathletic women. J Appl Physiol 50, 1300-1305.
27. Seals DR, Walker AE, Pierce GL & Lesniewski LA (2009). Habitual exercise and vascular ageing. J Physiol 587, 5541-5549.
28. Serebrovskaya TV, Karaban IN, Kolesnikova EE, Mishunina TM, Swanson RJ, Beloshitsky PV, Ilyin VN, Krasuk AN, Safronova OS & Kuzminskaya LA (2000). Geriatric men at altitude: hypoxic ventilatory sensitivity and blood dopamine changes. Respiration 67, 253-260.
29. Smith WD, Poulin MJ, Paterson DH & Cunningham DA (2001). Dynamic ventilatory response to acute isocapnic hypoxia in septuagenarians. Exp Physiol 86, 117-126.
30. Tanaka H, DeSouza CA & Seals DR (1998). Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol 18, 127-132.
31. Tanaka H & Seals DR (2003). Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol 95, 2152-2162.
32. Tatsumi K, Hannhart B, Pickett CK, Weil JV & Moore LG (1994). Effects of testosterone on hypoxic ventilatory and carotid body neural responsiveness. Am J Respir Crit Care Med 149, 1248-1253.
33. Teppema LJ & Dahan A (2010). The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev 90, 675-754.
34. Vovk A, Smith WD, Paterson ND, Cunningham DA & Paterson DH (2004). Peripheral chemoreceptor control of ventilation following sustained hypoxia in young and older adult humans. Exp Physiol 89, 647-656.
35. Wenninger JM, Olson EB Jr, Cotter CJ, Thomas CF & Behan M (2009). Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats. J Appl Physiol 106, 1522-1528.
36. White DP, Douglas NJ, Pickett CK, Weil JV & Zwillich CW (1983). Sexual influence on the control of breathing. J Appl Physiol 54, 874-879.
37. White DP, Schneider BK, Santen RJ, McDermott M, Pickett CK, Zwillich CW & Weil JV (1985). Influence of testosterone on ventilation and chemosensitivity in male subjects. J Appl Physiol 59, 1452-1457.