Alterations in the hypoxic ventilatory response with advancing age in awake rats

Journal of Physiology and Pharmacology

Volumn 61, Issue 2, 2010, Pages 227-232

  Pokorski, M ^a   Antosiewicz, J ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Aging; Breathing frequency; Hypoxia; Hypoxic ventilatory gain; Hypoxic ventilatory response; Rat

Indexed keywords

NITROGEN; OXYGEN;

AGING; ANIMAL EXPERIMENT; ARTICLE; BODY MASS; BODY PLETHYSMOGRAPHY; BREATHING; BREATHING RATE; BREED; CONTROLLED STUDY; HYPOXIA; LUNG MINUTE VOLUME; MALE; NONHUMAN; RAT; RESPIRATORY SYSTEM; STRESS; TIDAL VOLUME; WAKEFULNESS; AGE; ANIMAL; ANOXIA; BREATHING MECHANICS; LUNG VENTILATION; PATHOPHYSIOLOGY; PLETHYSMOGRAPHY; WISTAR RAT;

AGE FACTORS; AGING; ANIMALS; ANOXIA; MALE; PLETHYSMOGRAPHY; PULMONARY VENTILATION; RATS; RATS, WISTAR; RESPIRATORY MECHANICS; RESPIRATORY RATE; TIDAL VOLUME;

EID: 77955895765     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Grassi V, Cossi S, Leonardi R, Tantucci C. The aging lung: functional aspects. Aging (Milano) 1998; 10: 176-177.
2. Janssens JP, Pache JC, Nicod LP. Physiological changes of respiratory function associated with ageing. Eur Respir J 1999; 13: 197-205.
3. Levitzky MG. Effects of aging on the respiratory system. Physiologist 1984; 27: 102-107.
4. DeLorey DS, Babb TG. Progressive mechanical ventilatory constraints with aging. Am J Respir Crit Care Med 1999; 160: 169-177.
5. Pokorski M, Walski M, Dymecka A, Marczak M. The aging carotid body. J Physiol Pharmacol 2004; 55(Suppl 3): 107-113.
6. Dymecka A, Walski M, Pokorski M. Ultrastructural degradation of the carotid body in the aged rat: is there a role for atherosclerosis in the main carotid arteries? J Physiol Pharmacol 2006; 57(Suppl 4): 85-90.
7. Di Giulio C, Di Muzio M, Sabatino G, et al. Effect of chronic hyperoxia on young and old rat carotid body ultrastructure. Exp Gerontol 1998; 33: 319-329.
8. Kronenberg RS, Drage CW. Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 1973; 52: 1812-1819.
9. Peterson DD, Pack AI, Silage DA, Fishman AP. Effects of aging on ventilatory and occlusion pressure responses to hypoxia and hypercapnia. Am Rev Respir Dis 1981; 124: 387-391.
10. Kawakami Y, Yoshikawa T, Shida A, Asanuma Y. Relationship between hypoxic and hypercapnic ventilatory responses in man. Jpn J Physiol 1981; 31: 357-368.
11. Pokorski M, Marczak M. Ventilatory response to hypoxia in elderly women. Ann Human Biol 2003: 30: 53-64.
12. Chapman KR, Cherniack NS. Aging effects on the interaction of hypercapnia and hypoxia as ventilatory stimuli. J Gerontol 1987; 42: 202-209.
13. Serebrovskaya T, Karaban I, Mankovskaya I, Bernardi L, Passino C, Appenzeller O. Hypoxic ventilatory responses and gas exchange in patients with Parkinson's disease. Respiration 1998; 65: 28-33.
14. Schlenker EH, Goldman M. Ventilatory responses of aged male and female rats to hypercapnia and to hypoxia. Gerontology 1985; 31: 301-308.
15. Fukuda Y. Changes in ventilatory response to hypoxia in the rat during growth and aging. Pflugers Arch 1992; 421: 200-203.
16. Di Giulio C, Verratti V, Artese L, Petruccelli G, Walski M, Pokorski M. Aging and expression of heme oxygenase-1 and endothelin-1 in the rat carotid body after chronic hypoxia. J Physiol Pharmacol 2009; 60(Suppl 5): 41-44.
17. Sokolowska B, Rekawek A, Jozwik A. Respiratory responses to acute intermittent hypoxia and hypercapnia in awake rats. J Physiol Pharmacol 2008; 59(Suppl 6): 659-667.
18. Wysocka E, Cofta S, Cymerys M, Gozdzik J, Torlinski L, Batura-Gabryel H. The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients. J Physiol Pharmacol 2008; 59(Suppl 6): 761-769.
19. Schlenker EH, Goldmann M. A developmental evaluation of ventilation in aspartic-acid obese rats. Fed Proc 1984; 43: 433.
20. Ide T, Sakurai Y, Aono M, Nishino T. Contribution of peripheral chemoreception to the depression of the hypoxic ventilatory response during halothane anesthesia in cats. Anesthesiology 1999; 90: 1084-1091.
21. Wenninger JM, Olson EB Jr, Cotter CJ, Thomas CF, Behan M. Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats. J Appl Physiol 2009; 106: 1522-1528.
22. Budzinska K, Glowicki K, Karczewski WA, Kulesza J, Ryba M. The respiratory response to magnetic stimulation of the cortex in the unanaesthetized baboon. Acta Neurobiol Exp 1991; 51: 125-128.
23. Aminnoff MJ, Sears TA. Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones. J Physiol 1971; 215: 557-575.
24. Lipski J, Bektas A, Porter R. Short latency inputs to phrenic motoneurons from the sensorimotor cortex in the cat. Exp Brain Res 1986; 61: 280-290.
25. Gandevia SC, Rothwell JC. Activation of the human diaphragm from the motor cortex. J Physiol 1987; 384: 109-118.
26. Pokorski M, Trojecka A, Marczak M, Wierzbicka A, Jernajczyk W. Cortical activity during hypoxic hyperventilation. J Physiol Pharmacol 2003; 54(Suppl 1): 29-34.
27. Marek W, Muckenhoff K, Prabhakar NR. Significance of pulmonary vagal afferents for respiratory muscle activity in the cat. J Physiol Pharmacol 2008; 59(Suppl 6): 407-420.
28. Izumizaki M, Pokorski M, Homma I. Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse. J Appl Physiol 2004; 97: 1401-1407.
29. Bouverot P, Candas V, Libert JP. Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits. Respir Physiol 1973; 17: 209-219.
30. Martin-Body RL, Robson GJ, Sinclair JD. Respiratory effects of sectioning the carotid sinus glossopharyngeal and abdominal vagal nerves in the awake rat. J Physiol 1985; 361: 35-45.
31. Olson EB Jr, Vidruk EH, Dempsey JA. Carotid body excision significantly changes ventilatory control in awake rats. J Appl Physiol 1988; 64: 666-671.
32. Cragg PA, Schwenke DO. Role of carotid bodies in the guinea-pig. Adv Exp Med Biol 1996; 410: 377-381.
33. Shock NW. Physiological aspects of aging in man. Ann Rev Physiol 1961; 23: 97-122.