Adeno-associated viral vectors for anterograde axonal tracing with fluorescent proteins in nontransgenic and Cre driver mice

Current Protocols in Neuroscience

Volumn 1, Issue SUPPL.59, 2012, Pages

  Harris, Julie A ^a   Wook Oh, Seung ^a   Zeng, Hongkui ^a  

^a ALLEN INSTITUTE FOR BRAIN SCIENCE   (United States)

Author keywords

AAV; Anterograde tracer; Cre dependent virus; Neural circuits; rAAV; Viral tracer

Indexed keywords

FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR; RED FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; CRE RECOMBINASE; INTEGRASE; PHOTOPROTEIN;

ARTICLE; BRAIN REGION; DENDRITE; EXPERIMENTAL MOUSE; IONTOPHORESIS; NERVE FIBER; NERVE FIBER TRANSPORT; NEUROIMAGING; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATOSENSORY CORTEX; STEREOTACTIC TREATMENT; STEREOTAXIC SURGERY; STRATEGIC PLANNING; SURGICAL APPROACH; ADENO ASSOCIATED VIRUS; ANIMAL; CYTOLOGY; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; MOUSE; NERVE TRACT; NEUROANATOMICAL TRACT TRACING; PROTEIN ENGINEERING; TRANSGENIC MOUSE; ULTRASTRUCTURE; VIROLOGY;

ANIMALS; AXONAL TRANSPORT; AXONS; DEPENDOVIRUS; GENETIC VECTORS; INTEGRASES; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; NEURAL PATHWAYS; NEUROANATOMICAL TRACT-TRACING TECHNIQUES; PROTEIN ENGINEERING;

EID: 84868124963     PISSN: 19348584     EISSN: 19348576     Source Type: Journal    
DOI: 10.1002/0471142301.ns0120s59     Document Type: Article

References (25)

1. Atasoy, D., Aponte, Y., Su, H.H., and Sternson, S.M. 2008. A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 28:7025-7030.
2. Bennett, J.,Duan, D., Engelhardt, J.F., andMaguire, A.M. 1997. Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction. Invest. Ophthalmol. Vis. Sci. 38:2857-2863.
3. Burger, C., Gorbatyuk, O.S., Velardo, M.J., Peden, C.S., Williams, P., Zolotukhin, S., Reier, P.J., Mandel, R.J., and Muzyczka, N. 2004. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol. Ther. 10:302-317.
4. Cearley, C.N. and Wolfe, J.H. 2007. A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. J. Neurosci. 27:9928-9940.
5. Cearley, C.N., Vandenberghe, L.H., Parente, M.K., Carnish, E.R., Wilson, J.M., and Wolfe, J.H. 2008. Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol. Ther. 16:1710-1718.
6. Chamberlin, N.L., Du, B., de Lacalle, S., and Saper, C.B. 1998. Recombinant adeno-associated virus vector: Use for transgene expression and anterograde tract tracing in the CNS. Brain Res. 793:169-175.
7. Dhillon, H., Zigman, J.M., Ye, C., Lee, C.E., McGovern, R.A., Tang, V., Kenny, C.D., Christiansen, L.M., White, R.D., Edelstein, E.A., Coppari, R., Balthasar, N., Cowley,M.A., Chua, S. Jr., Elmquist, J.K., and Lowell, B.B. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49:191-203.
8. Gautron, L., Lazarus,M., Scott, M.M., Saper, C.B., and Elmquist, J.K. 2010. Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J. Comp. Neurol. 518:2090-2108.
9. Hadaczek, P., Eberling, J.L., Pivirotto, P., Bringas, J., Forsayeth, J., and Bankiewicz, K.S. 2010. Eight years of clinical improvement in MPTPlesioned primates after gene therapy with AAV2-hAADC. Mol. Ther. 18:1458-1461.
10. Kravitz, A.V., Freeze, B.S., Parker, P.R., Kay, K., Thwin, M.T., Deisseroth, K., and Kreitzer, A.C. 2010. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature 466:622-626.
11. Kuhlman, S.J. and Huang, Z.J. 2008. Highresolution labeling and functional manipulation of specific neuron types in mouse brain by Cre-activated viral gene expression. PLoS One 3:e2005.
12. Madisen, L., Zwingman, T.A., Sunkin, S.M., Oh, S.W., Zariwala, H.A., Gu, H., Ng, L.L., Palmiter, R.D., Hawrylycz, M.J., Jones, A.R., Lein, E.S., and Zeng, H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13:133-140.
13. Marik, S.A., Yamahachi, H., McManus, J.N., Szabo, G., and Gilbert, C.D. 2010. Axonal dynamics of excitatory and inhibitory neurons in somatosensory cortex.PLoS Biol. 8:e1000395.
14. Mittmann, W., Wallace, D.J., Czubayko, U., Herb, J.T., Schaefer,A.T., Looger, L.L., Denk,W., and Kerr, J.N. 2011. Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo. Nat. Neurosci. 14:1089-1093.
15. Passini, M.A., Watson, D.J., Vite, C.H., Landsburg, D.J., Feigenbaum, A.L., and Wolfe, J.H. 2003. Intraventricular brain injection of adenoassociated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of betaglucuronidase-deficient mice. J. Virol. 77:7034-7040.
16. nd edition). Academic Press, New York.
17. Ragan, T., Kadiri, L.R., Venkataraju, K.U., Bahlmann, K., Sutin, J., Taranda, J., Arganda-Carreras, I., Kim, Y., Seung, H.S., and Osten, P. 2012. Serial two-photon tomography for automated ex vivo mouse brain imaging. Nat. Methods 9:255-258.
18. Spires, T.L., Meyer-Luehmann, M., Stern, E.A., McLean, P.J., Skoch, J., Nguyen, P.T., Bacskai, B.J., and Hyman, B.T. 2005. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25:7278-7287.
19. Sternson, S. and Betley, J.N. 2011. Adenoassociated viral vectors for mapping, monitoring, and manipulating neural circuits. Hum. Gene Ther.
20. Stettler, D.D.,Yamahachi, H., Li,W., Denk,W., and Gilbert, C.D. 2006. Axons and synaptic boutons are highly dynamic in adult visual cortex. Neuron 49:877-887.
21. Taymans, J.M., Vandenberghe, L.H., Haute, C.V., Thiry, I., Deroose, C.M., Mortelmans, L., Wilson, J.M., Debyser, Z., and Baekelandt, V. 2007. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum. Gene Ther. 18:195-206.
22. Van Vliet, K.M., Blouin, V., Brument, N., Agbandje-McKenna, M., and Snyder, R.O. 2008. The role of the adeno-associated virus capsid in gene transfer. Methods Mol. Biol. 437:51-91.
23. Vandenberghe, L.H., Breous, E., Nam, H.J., Gao, G., Xiao, R., Sandhu, A., Johnston, J., Debyser, Z., Agbandje-McKenna, M., and Wilson, J.M. 2009. Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Ther. 16:1416-1428.
24. Wu, Z., Asokan, A., and Samulski, R.J. 2006. Adeno-associated virus serotypes:Vector toolkit for human gene therapy. Mol. Ther. 14:316-327.
25. Xiao, X., Li, J., McCown, T.J., and Samulski, R.J. 1997. Gene transfer by adeno-associated virus vectors into the central nervous system. Exp. Neurol. 144:113-124.