Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease

American Journal of Pathology

Volumn 181, Issue 5, 2012, Pages 1725-1734

  Szczepanek, Steven M ^a   McNamara, Jeffrey T ^a   Secor, Eric R ^a   Natarajan, Prabitha ^a   Guernsey, Linda A ^a   Miller, Lauren A ^a   Ballesteros, Enrique ^a   Jellison, Evan ^a   Thrall, Roger S ^a   Andemariam, Biree ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; RANTES;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FRACTIONATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; IMMUNE STATUS; IMMUNOPHENOTYPING; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SICKLE CELL ANEMIA;

EID: 84868124885     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.07.034     Document Type: Article

References (31)

1. O.S. Platt, D.J. Brambilla, W.F. Rosse, P.F. Milner, O. Castro, M.H. Steinberg, P.P. Klug Mortality in sickle cell disease: life expectancy and risk factors for early death N Engl J Med 330 1994 1639 1644
2. G. Harms, M.J. Hardonk, W. Timens In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle Infect Immun 64 1996 4220 4225 (Pubitemid 26318145)
3. H. Wardemann, T. Boehm, N. Dear, R. Carsetti B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen J Exp Med 195 2002 771 780 (Pubitemid 34259721)
4. P.U. Cameron, P. Jones, M. Gorniak, K. Dunster, E. Paul, S. Lewin, I. Woolley, D. Spelman Splenectomy associated changes in IgM memory B cells in an adult spleen registry cohort PLoS One 6 2011 e23164
5. K.M. Haas, J.C. Poe, D.A. Steeber, T.F. Tedder B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae Immunity 23 2005 7 18 (Pubitemid 41019653)
6. M.M. Rosado, A. Aranburu, F. Capolunghi, E. Giorda, S. Cascioli, F. Cenci, S. Petrini, E. Miller, T. Leanderson, G.F. Bottazzo, P.G. Natali, R. Carsetti From the fetal liver to spleen and gut: the highway to natural antibody Mucosal Immunol 2 2009 351 361
7. A.J. Battersby, H.H. Knox-Macaulay, E.D. Carrol Susceptibility to invasive bacterial infections in children with sickle cell disease Pediatr Blood Cancer 55 2010 401 406
8. C. Paszty, C.M. Brion, E. Manci, H.E. Witkowska, M.E. Stevens, N. Mohandas, E.M. Rubin Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease Science 278 1997 876 878 (Pubitemid 27467927)
9. J. Holtzclaw, D. Jack, S. Aguayo, J. Eckman, J. Roman, L. Hsu Enhanced pulmonary and systemic response to endotoxin in transgenic sickle cell mice Am J Respir Crit Care Med 169 2004 687 695 (Pubitemid 38338920)
10. R.N. Paul, O.L. Castro, A. Aggarwal, P.A. Oneal Acute chest syndrome: sickle cell disease Eur J Haematol 87 2011 191 207
11. A.D. Campbell, S. Cui, L. Shi, R. Urbonya, A. Mathias, K. Bradley, K.O. Bonsu, R.R. Douglas, B. Halford, L. Schmidt, D. Harro, D. Giacherio, K. Tanimoto, O. Tanabe, J.D. Engel Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes Proc Natl Acad Sci U S A 108 2011 18808 18813
12. C. Booth, B. Inusa, S.K. Obaro Infection in sickle cell disease: a review Int J Infect Dis 14 2010 e2 e12
13. R. Khatib, R. Rabah, S.A. Sarnaik The spleen in the sickling disorders: an update Pediatr Radiol 39 2009 17 22
14. G.D. Overturf Pneumococcal vaccination of children Semin Pediatr Infect Dis 13 2002 155 164
15. M.W. Burnett, J.W. Bass, B.A. Cook Etiology of osteomyelitis complicating sickle cell disease Pediatrics 101 1998 296 297 (Pubitemid 28076667)
16. Y.S. Kang, J.Y. Kim, S.A. Bruening, M. Pack, A. Charalambous, A. Pritsker, T.M. Moran, J.M. Loeffler, R.M. Steinman, C.G. Park The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen Proc Natl Acad Sci U S A 101 2004 215 220 (Pubitemid 38084230)
17. E.A. Koppel, M. Litjens, V.C. van den Berg, Y. van Kooyk, T.B. Geijtenbeek Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae Mol Immunol 45 2008 2881 2887
18. R.E. Mebius, G. Kraal Structure and function of the spleen Nat Rev Immunol 5 2005 606 616 (Pubitemid 41113192)
19. N. Rautonen, N.L. Martin, J. Rautonen, Y. Rooks, W.C. Mentzer, D.W. Wara Low number of antibody producing cells in patients with sickle cell anemia Immunol Lett 34 1992 207 211 (Pubitemid 23005784)
20. M. Venkataraman, M.P. Westerman B-cell changes occur in patients with sickle cell anemia Am J Clin Pathol 84 1985 153 158 (Pubitemid 15249740)
21. M.O. Adedeji Lymphocyte subpopulations in homozygous sickle cell anaemia Acta Haematol 74 1985 10 13 (Pubitemid 16246703)
22. S.A. Kaaba, S.A. al-Harbi Reduced levels of CD2+ cells and T-cell subsets in patients with sickle cell anaemia Immunol Lett 37 1993 77 81 (Pubitemid 23255325)
23. D.D. Taub, A.R. Lloyd, K. Conlon, J.M. Wang, J.R. Ortaldo, A. Harada, K. Matsushima, D.J. Kelvin, J.J. Oppenheim Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells J Exp Med 177 1993 1809 1814 (Pubitemid 23146150)
24. A. Crawford, J.M. Angelosanto, K.L. Nadwodny, S.D. Blackburn, E.J. Wherry A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection PLoS Pathog 7 2011 e1002098
25. C. Morrison, P. Maurtua-Neumann, M.T. Myint, S.S. Drury, R.E. Bégué Pandemic (H1N1) 2009 outbreak at camp for children with hematologic and oncologic conditions Emerg Infect Dis 17 2011 87 89
26. J.E. Jacobs, K. Quirolo, E. Vichinsky Novel influenza A (H1N1) viral infection in pediatric patients with sickle-cell disease Pediatr Blood Cancer 56 2011 95 98
27. S. Chuncharunee, N. Archararit, P. Hathirat, U. Udomsubpayakul, V. Atichartakarn Levels of serum interleukin-6 and tumor necrosis factor in postsplenectomized thalassemic patients J Med Assoc Thai 80 Suppl 1 1997 S86 S91
28. E. Graido-Gonzalez, J.C. Doherty, E.W. Bergreen, G. Organ, M. Telfer, M.A. McMillen Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis Blood 92 1998 2551 2555 (Pubitemid 28453000)
29. A. Pathare, S. Al Kindi, A.A. Alnaqdy, S. Daar, H. Knox-Macaulay, D. Dennison Cytokine profile of sickle cell disease in Oman Am J Hematol 77 2004 323 328 (Pubitemid 39578309)
30. S.C. Taylor, S.J. Shacks, R.A. Mitchell, A. Banks Serum interleukin-6 levels in the steady state of sickle cell disease J Interferon Cytokine Res 15 1995 1061 1064 (Pubitemid 26006284)
31. S.C. Taylor, S.J. Shacks, Z. Qu, P. Wiley Type 2 cytokine serum levels in healthy sickle cell disease patients J Natl Med Assoc 89 1997 753 757 (Pubitemid 127455040)