Can fish oil dissolve gallstones?

Journal of Gastroenterology and Hepatology (Australia)

Volumn 27, Issue 11, 2012, Pages 1649-1651

  Lee, Dong Ki ^a   Jang, Sung Ill ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; MUCIN; OMEGA 3 FATTY ACID; URSODEOXYCHOLIC ACID;

ARTICLE; ATHEROSCLEROSIS; BODY MASS; CHOLESTEROL SATURATION INDEX; DIET; DYSLIPIDEMIA; GALLSTONE; PRIORITY JOURNAL;

ANIMALS; CHOLESTEROL, DIETARY; FATTY ACIDS, OMEGA-3; GALLSTONES; MALE; MUCINS;

EID: 84868122796     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2012.07234.x     Document Type: Article

References (21)

1. Kim JK, Cho SM, Kang SH etal. N-3 polyunsaturated fatty acid attenuates cholesterol gallstones by suppressing mucin production with a high cholesterol diet in mice. J. Gastroenterol. Hepatol. 2012; 27: 1745-1751.
2. Hull MA. Omega-3 polyunsaturated fatty acids. Best Pract. Res. Clin. Gastroenterol. 2011; 25: 547-554.
3. Papazafiropoulou AK, Kardara MS, Pappas SI. Pleiotropic effects of omega-3 fatty acids. Recent Pat. Endocr. Metab. Immune Drug Discov. 2012; 6: 40-46.
4. Boss LP, Lanier AP, Dohan PH, Bender TR. Cancers of the gallbladder and biliary tract in Alaskan natives: 1970-79. J. Natl. Cancer Inst. 1982; 69: 1005-1007.
5. Schaefer O. When the Eskimo comes to town. Nutr. Today 1971; 6: 8-16.
6. Balasubramaniam S, Simons LA, Chang S, Hickie JB. Reduction in plasma cholesterol and increase in biliary cholesterol by a diet rich in n-3 fatty acids in the rat. J. Lipid Res. 1985; 26: 684-689.
7. Booker ML, Scott TE, La Morte WW. Effects of dietary fish oil on biliary phospholipids and prostaglandin synthesis in the cholesterol-fed prairie dog. Lipids 1990; 25: 27-32.
8. Scobey MW, Johnson FL, Parks JS, Rudel LL. Dietary fish oil effects on biliary lipid secretion and cholesterol gallstone formation in the African green monkey. Hepatology 1991; 14: 679-684.
9. Smit MJ, Temmerman AM, Wolters H, Kuipers F, Beynen AC, Vonk RJ. Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats. J. Clin. Invest. 1991; 88: 943-951.
10. Cohen BI, Mosbach EH, Ayyad N, Miki S, McSherry CK. Dietary fat and fatty acids modulate cholesterol cholelithiasis in the hamster. Lipids 1992; 27: 526-532.
11. Berr F, Goetz A, Schreiber E, Paumgartner G. Effect of dietary n-3 versus n-6 polyunsaturated fatty acids on hepatic excretion of cholesterol in the hamster. J. Lipid Res. 1993; 34: 1275-1284.
12. Smit MJ, Verkade HJ, Havinga R etal. Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats. J. Lipid Res. 1994; 35: 301-310.
13. Magnuson TH, Lillemoe KD, High RC, Pitt HA. Dietary fish oil inhibits cholesterol monohydrate crystal nucleation and gallstone formation in the prairie dog. Surgery 1995; 118: 517-523.
14. Bravo E, Cantafora A, DeLuca V, Tripodi M, Avella M, Botham KM. The mechanism underlying the hypocholesterolemic effect of chronic fish oil feeding in rats is not due to increased excretion of dietary cholesterol. Atherosclerosis 1998; 139: 253-263.
15. Wechsler JG, Swobodnik W, Wenzel H, Saal D, Janowitz P, Ditschuneit H. [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. Z. Gastroenterol. 1989; 27: 254-257.
16. Jonkers IJ, Smelt AH, Princen HM etal. Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia. J. Nutr. 2006; 136: 987-991.
17. Berr F, Holl J, Jungst D etal. Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease. Hepatology 1992; 16: 960-967.
18. Mendez-Sanchez N, Gonzalez V, Aguayo P etal. Fish oil (n-3) polyunsaturated fatty acids beneficially affect biliary cholesterol nucleation time in obese women losing weight. J. Nutr. 2001; 131: 2300-2303.
19. Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. N. Engl. J. Med. 1988; 318: 549-557.
20. Lee SP, Carey MC, LaMont JT. Aspirin prevention of cholesterol gallstone formation in prairie dogs. Science 1981; 211: 1429-1431.
21. Van Erpecum KJ, Portincasa P, Eckhardt E, Go PM, VanBerge-Henegouwen GP, Groen AK. Ursodeoxycholic acid reduces protein levels and nucleation-promoting activity in human gallbladder bile. Gastroenterology 1996; 110: 1225-1237.