N-3 polyunsaturated fatty acid attenuates cholesterol gallstones by suppressing mucin production with a high cholesterol diet in mice

Journal of Gastroenterology and Hepatology (Australia)

Volumn 27, Issue 11, 2012, Pages 1745-1751

  Kim, Ja Kyung ^a   Cho, Soo Min ^c   Kang, So Hee ^a   Kim, Eunjung ^b   Yi, Hee ^c   Yun, Eun Sun ^c   Lee, Dong Goo ^c   Cho, Hee Jung ^c   Paik, Yong Han ^a   Choi, Yang Kyu ^c   Haam, Seung Joo ^b   Shin, Ho Chul ^c   Lee, Dong Ki ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

Cholesterol gallstone; High cholesterol diet; Mucin; N 3 polyunsaturated fatty acid; Phopholipid

Indexed keywords

CHOLESTEROL; MUCIN; OMEGA 3 FATTY ACID; PHOSPHOLIPID; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL DIET; CHOLESTEROL STONE; CONTROLLED STUDY; DIET SUPPLEMENTATION; GALLBLADDER; GENE EXPRESSION; LIVER HYPERTROPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALS; BILE; CHOLAGOGUES AND CHOLERETICS; CHOLESTEROL; CHOLESTEROL, DIETARY; DRUG THERAPY, COMBINATION; FATTY ACIDS, OMEGA-3; GALLBLADDER; GALLSTONES; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; MUCIN 5AC; MUCIN-2; MUCIN-5B; MUCIN-6; MUCINS; MUCOUS MEMBRANE; PHOSPHOLIPIDS; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; URSODEOXYCHOLIC ACID;

EID: 84868101478     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2012.07227.x     Document Type: Article

References (18)

1. Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol. Clin. North Am. 1991; 20: 1-19.
2. Mendez-Sanchez N, Zamora-Valdes D, Chavez-Tapia NC, Uribe M. Role of diet in cholesterol gallstone formation. Clin. Chim. Acta 2007; 376: 1-8.
3. Huang YQ, Gu C. [The changing pattern of cholelithiasis in Tianjin]. Zhonghua Wai Ke Za Zhi 1987; 25: 346, 381.
4. Simopoulos AP. Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects. World Rev. Nutr. Diet. 2003; 92: 1-22.
5. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed. Pharmacother. 2002; 56: 365-379.
6. Simopoulos AP. Essential fatty acids in health and chronic diseases. Forum Nutr. 2003; 56: 67-70.
7. Sekiya M, Yahagi N, Matsuzaka T etal. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 2003; 38: 1529-1539.
8. Wang HH, Portincasa P, Wang DQ. Molecular pathophysiology and physical chemistry of cholesterol gallstones. Front. Biosci. 2008; 13: 401-423.
9. Podda M, Zuin M, Carulli N, Ponz de Leon M, Dioguardi ML. Gallstone dissolution after 6 months of ursodeoxycholic acid (UDCA): effectiveness of different doses. J. Int. Med. Res. 1982; 10: 59-63.
10. Schaefer O. When the Eskimo comes to town. Nutr. Today 1971; 6: 8-16.
11. Wechsler JG, Swobodnik W, Wenzel H, Saal D, Janowitz P, Ditschuneit H. [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. Z. Gastroenterol. 1989; 27: 254-257.
12. Scobey MW, Johnson FL, Parks JS, Rudel LL. Dietary fish oil effects on biliary lipid secretion and cholesterol gallstone formation in the African green monkey. Hepatology 1991; 14: 679-684.
13. Magnuson TH, Lillemoe KD, High RC, Pitt HA. Dietary fish oil inhibits cholesterol monohydrate crystal nucleation and gallstone formation in the prairie dog. Surgery 1995; 118: 517-523.
14. Villanova N, Bazzoli F, Taroni F etal. Gallstone recurrence after successful oral bile acid treatment. A 12-year follow-up study and evaluation of long-term postdissolution treatment. Gastroenterology 1989; 97: 726-731.
15. Van Erpecum KJ, Portincasa P, Eckhardt E, Go PM, VanBerge-Henegouwen GP, Groen AK. Ursodeoxycholic acid reduces protein levels and nucleation-promoting activity in human gallbladder bile. Gastroenterology 1996; 110: 1225-1237.
16. Wang HH, Portincasa P, Mendez-Sanchez N, Uribe M, Wang DQ. Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology 2008; 134: 2101-2110.
17. Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J. Lipid Res. 1997; 38: 1395-1411.
18. Lee SP, LaMont JT, Carey MC. Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones. J. Clin. Invest. 1981; 67: 1712-1723.