Structure and Activity Analysis of Inauhzin Analogs as Novel Antitumor Compounds That Induce p53 and Inhibit Cell Growth

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Zhang, Qi ^a,b   Ding, Derong ^b   Zeng, Shelya X ^a,b   Ye, Qi Zhuang ^b   Lu, Hua ^a,b,c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL]HEXAN1 ONE; 1 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]PENT 4 EN 1 ONE; 1 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]PENT 4 YN 1 ONE; 1 [ACRIDIN 10(9H) YL] 2 [[5 (2 HYDROXYETHYL) 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL]THIO]BUTAN 1 ONE; 2 [(5 BENZOYL 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(5 NICOTINOYL 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)HEXAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOXAZIN 10 YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (2 CHLORO 10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (2 METHOXY 10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (2,3 DIHYDRO 1H PYRROLO[3,2B]PYRIDINE 1 YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (2H BENZO[B][1,4]THIAZIN 4(3H) YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (3,4 DIHYDROQUINOLIN 1(2H) YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (ACRIDIN 10(9H) YL)BUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 THIOMORPHOLINOBUTAN 1 ONE; 2 [(5H [1,2,4]TRIAZINO[5,6 B]INDOLE 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(7 BROMO 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(7 CHLORO 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(7 FLUORO 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(7 METHOXY 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [(7 METHYL 5H [1,2,4]TRIAZINO[5,6 B]INDOL 3 YL)THIO] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 2 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]ACETIC ACID; 2 [[5 (2 HYDROXYETHYL) 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]THIOL] 1 (10H PHENOTHIAZIN 10 YL)BUTAN 1 ONE; 5 [5 OXO 5 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]PENTYL]TETRAHYDRO 1H THIENO[2,3 D]IMIDAZOLE 2(5H)ONE; 5 BROMO 1 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]PENTAN 1 ONE; ANTINEOPLASTIC AGENT; ETHYL 2 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]ACETIC ACID; ETHYL 5 OXO 5 [3 [[1 OXO 1 (10H PHENOTHIAZIN 10 YL)BUTAN 2 YL]THIO] 5H [1,2,4]TRIAZINO[5,6 B]INDOL 5 YL]PENTANOIC ACID; PROTEIN P53; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL PROLIFERATION; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; PROTEIN INDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; HUMANS; INDOLES; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84868122021     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046294     Document Type: Article

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