Glutathione mediated reductive activation and mitochondrial dysfunction play key roles in lithium induced oxidative stress and cytotoxicity in liver

BioMetals

Volumn 25, Issue 5, 2012, Pages 863-873

  Eskandari, Mohammad Reza ^a   Fard, Javad Khalili ^b   Hosseini, Mir Jamal ^a,b   Pourahmad, Jalal ^b  

^a ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Glutathione; Hepatotoxicity; Lithium; Methylation; Oxidative stress

Indexed keywords

4 METHYLPYRAZOLE; 4 PHENYLIMIDAZOLE; AZACITIDINE; BETAINE; BUTYLCRESOL; CARNITINE; CHLOROQUINE; CYCLOSPORIN; CYTOCHROME C; CYTOCHROME P450 2E1; DEFEROXAMINE; DIMETHYL SULFOXIDE; DIPHENYLIODONIUM SALT; FOLIC ACID; GLUTATHIONE; LITHIUM CARBONATE; MANNITOL; METHIONINE; METHYLAMINE; MONENSIN; REACTIVE OXYGEN METABOLITE; SODIUM SELENITE; TRIFLUOPERAZINE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DETOXIFICATION; ELECTRON TRANSPORT; ENZYME RELEASE; LIVER CELL; MALE; METHYLATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT;

ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOCHROMES C; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEPATOCYTES; LITHIUM; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 84868112785     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9552-8     Document Type: Article

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