-
1
-
-
62549128139
-
A census of human transcription factors: Function, expression and evolution
-
Vaquerizas JM, Kummerfeld SK, Teichmann SA, et al. (2009) A census of human transcription factors: function, expression and evolution. Nat Rev 10, 252-263.
-
(2009)
Nat Rev
, vol.10
, pp. 252-263
-
-
Vaquerizas, J.M.1
Kummerfeld, S.K.2
Teichmann, S.A.3
-
2
-
-
50349087339
-
Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake
-
Malmberg SE & Adams CM (2008) Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem 283, 19229-19234.
-
(2008)
J Biol Chem
, vol.283
, pp. 19229-19234
-
-
Malmberg, S.E.1
Adams, C.M.2
-
3
-
-
0036789999
-
Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
-
Arantes VC, Teixeira VP, Reis MA, et al. (2002) Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation. J Nutr 132, 3030-3035.
-
(2002)
J Nutr
, vol.132
, pp. 3030-3035
-
-
Arantes, V.C.1
Teixeira, V.P.2
Reis, M.A.3
-
4
-
-
0017305263
-
Obesity in young men after famine exposure in utero and early infancy
-
Ravelli GP, Stein ZA & Susser MW (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 7, 349-353.
-
(1976)
N Engl J Med
, vol.7
, pp. 349-353
-
-
Ravelli, G.P.1
Stein, Z.A.2
Susser, M.W.3
-
5
-
-
0036862451
-
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
-
DOI 10.1038/sj.ejhg.5200859
-
Kaati G, Bygren LO & Edvinsson S (2002) Cardiovascular and diabetes mortality determined by nutrition during parents' and grand parents' slow growth period. Eur J Hum Genet 10, 682-688. (Pubitemid 35460575)
-
(2002)
European Journal of Human Genetics
, vol.10
, Issue.11
, pp. 682-688
-
-
Kaati, G.1
Bygren, L.O.2
Edvinson, S.3
-
7
-
-
0016824053
-
Leucine. A possible regulator of protein turnover in muscle
-
Buse MG & Reid SS (1975) Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56, 1250-1261.
-
(1975)
J Clin Invest
, vol.56
, pp. 1250-1261
-
-
Buse, M.G.1
Reid, S.S.2
-
8
-
-
0016431688
-
Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm
-
Fulks RM, Li JB & Goldberg AL (1975) Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250, 290-298.
-
(1975)
J Biol Chem
, vol.250
, pp. 290-298
-
-
Fulks, R.M.1
Li, J.B.2
Goldberg, A.L.3
-
9
-
-
0018128453
-
Influence of amino acid availability on protein turnover in perfused skeletal muscle
-
Li JB & Jefferson LS (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochimica et Biophysica Acta 544, 351-359. (Pubitemid 9052911)
-
(1978)
Biochimica et Biophysica Acta
, vol.544
, Issue.2
, pp. 351-359
-
-
Li, J.B.1
Jefferson, L.S.2
-
10
-
-
0019197010
-
Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects
-
Hagenfeldt L, Eriksson S & Wahren J (1980) Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clin Sci (Lond) 59, 173-181. (Pubitemid 11230848)
-
(1980)
Clinical Science
, vol.59
, Issue.3
, pp. 173-181
-
-
Hagenfeldt, L.1
Eriksson, S.2
Wahren, J.3
-
11
-
-
0020312363
-
Failure of leucine to stimulate protein synthesis in vivo
-
McNurlan MA, Fern EB & Garlick PJ (1982) Failure of leucine to stimulate protein synthesis in vivo. Biochem J 204, 831-838. (Pubitemid 12009160)
-
(1982)
Biochemical Journal
, vol.204
, Issue.3
, pp. 831-838
-
-
McNurlan, M.A.1
Fern, E.B.2
Garlick, P.J.3
-
12
-
-
0019500769
-
Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man
-
Mitch WE, Walser M & Sapir DG (1981) Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man. J Clin Invest 67, 553-562. (Pubitemid 11141739)
-
(1981)
Journal of Clinical Investigation
, vol.67
, Issue.2
, pp. 553-562
-
-
Mitch, W.E.1
Walser, M.2
Sapir, D.G.3
-
13
-
-
0017334005
-
Nitrogen sparing induced early in starvation by infusion of branched chain ketoacids
-
DOI 10.1016/0026-0495(77)90077-4
-
Sapir DG & Walser M (1977) Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacids. Metab: Clin Experi 26, 301-308. (Pubitemid 8038161)
-
(1977)
Metabolism: Clinical and Experimental
, vol.26
, Issue.3
, pp. 301-308
-
-
Sapir, D.G.1
Walser, M.2
-
14
-
-
0017825464
-
Effect of starvation on the turnover and metabolic response to leucine
-
Sherwin RS (1978) Effect of starvation on the turnover and metabolic response to leucine. J Clin Invest 61, 1471-1481. (Pubitemid 8361873)
-
(1978)
Journal of Clinical Investigation
, vol.61
, Issue.6
, pp. 1471-1481
-
-
Sherwin, R.S.1
-
15
-
-
0033980371
-
Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased elF4F formation
-
Anthony JC, Anthony TG, Kimball SR, et al. (2000) Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 130, 139-145. (Pubitemid 30073785)
-
(2000)
Journal of Nutrition
, vol.130
, Issue.2
, pp. 139-145
-
-
Anthony, J.C.1
Anthony, T.G.2
Kimball, S.R.3
Vary, T.C.4
Jefferson, L.S.5
-
16
-
-
14944341734
-
Oral leucine administration stimulates protein synthesis in rat skeletal muscle
-
Crozier SJ, Kimball SR, Emmert SW, et al. (2005) Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 135, 376-382. (Pubitemid 40365191)
-
(2005)
Journal of Nutrition
, vol.135
, Issue.3
, pp. 376-382
-
-
Crozier, S.J.1
Kimball, S.R.2
Emmert, S.W.3
Anthony, J.C.4
Jefferson, L.S.5
-
17
-
-
0033808169
-
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
-
Anthony JC, Yoshizawa F, Anthony TG, et al. (2000) Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130, 2413-2419.
-
(2000)
J Nutr
, vol.130
, pp. 2413-2419
-
-
Anthony, J.C.1
Yoshizawa, F.2
Anthony, T.G.3
-
18
-
-
78649544447
-
Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation
-
Murgas Torrazza R, Suryawan A, Gazzaneo MC, et al. (2010) Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr 140, 2145-2152.
-
(2010)
J Nutr
, vol.140
, pp. 2145-2152
-
-
Murgas Torrazza, R.1
Suryawan, A.2
Gazzaneo, M.C.3
-
19
-
-
0014735856
-
Synergistic effect of certain amino acid pairs upon insulin secretion in man
-
Floyd JC Jr, Fajans SS, Pek S, et al. (1970) Synergistic effect of certain amino acid pairs upon insulin secretion in man. Diabetes 19, 102-108.
-
(1970)
Diabetes
, vol.19
, pp. 102-108
-
-
Floyd Jr., J.C.1
Fajans, S.S.2
Pek, S.3
-
20
-
-
0023723070
-
Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids
-
Garlick PJ & Grant I (1988) Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J 254, 579-584.
-
(1988)
Biochem J
, vol.254
, pp. 579-584
-
-
Garlick, P.J.1
Grant, I.2
-
21
-
-
0036230645
-
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
-
Anthony JC, Reiter AK, Anthony TG, et al. (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51, 928-936. (Pubitemid 34438333)
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 928-936
-
-
Anthony, J.C.1
Reiter, A.K.2
Anthony, T.G.3
Crozier, S.J.4
Lang, C.H.5
MacLean, D.A.6
Kimball, S.R.7
Jefferson, L.S.8
-
22
-
-
0036081155
-
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
-
Anthony JC, Lang CH, Crozier SJ, et al. (2002) Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol 282, E1092-E1101. (Pubitemid 34654724)
-
(2002)
American Journal of Physiology - Endocrinology and Metabolism
, vol.282
, Issue.5
-
-
Anthony, J.C.1
Lang, C.H.2
Crozier, S.J.3
Anthony, T.G.4
MacLean, D.A.5
Kimball, S.R.6
Jefferson, L.S.7
-
23
-
-
0034830022
-
Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
-
Greiwe JS, Kwon G, McDaniel ML, et al. (2001) Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. Am J Physiol 281, E466-E471.
-
(2001)
Am J Physiol
, vol.281
-
-
Greiwe, J.S.1
Kwon, G.2
McDaniel, M.L.3
-
24
-
-
1542754878
-
Body composition in adolescent girls with Type 1 diabetes
-
DOI 10.1046/j.1464-5491.2003.01055.x
-
Ingberg CM, Sarnblad S, Palmer M, et al. (2003) Body composition in adolescent girls with type 1 diabetes. Diabet Med 20, 1005-1011. (Pubitemid 41701481)
-
(2003)
Diabetic Medicine
, vol.20
, Issue.12
, pp. 1005-1011
-
-
Ingberg, C.-M.1
Sarnblad, S.2
Palmer, M.3
Schvarcz, E.4
Berne, C.5
Aman, J.6
-
25
-
-
79960621627
-
The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus
-
Desikan V, Mileva I, Garlick J, et al. (2010) The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus. Int J Pediatr Endocrinol 2010, 493258.
-
(2010)
Int J Pediatr Endocrinol 2010
, pp. 493258
-
-
Desikan, V.1
Mileva, I.2
Garlick, J.3
-
26
-
-
77953040366
-
Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases
-
Baptista IL, Leal ML, Artioli GG, et al. (2010) Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 41, 800-808.
-
(2010)
Muscle Nerve
, vol.41
, pp. 800-808
-
-
Baptista, I.L.1
Leal, M.L.2
Artioli, G.G.3
-
27
-
-
70349604105
-
Regulation of muscle protein degradation, not synthesis by dietary leucine in rats fed a protein-deficient diet
-
Sugawara T, Ito Y, Nishizawa N, et al. (2009) Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet. Amino Acids 37, 609-616.
-
(2009)
Amino Acids
, vol.37
, pp. 609-616
-
-
Sugawara, T.1
Ito, Y.2
Nishizawa, N.3
-
28
-
-
0028878309
-
Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle
-
Biolo G, Fleming RY, Maggi SP, et al. (1995) Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol 268, (1 Pt 1), E75-E84.
-
(1995)
Am J Physiol
, vol.268
, Issue.1 PART 1
-
-
Biolo, G.1
Fleming, R.Y.2
Maggi, S.P.3
-
29
-
-
78149245600
-
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
-
Glynn EL, Fry CS, Drummond MJ, et al. (2010) Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140, 1970-1976.
-
(2010)
J Nutr
, vol.140
, pp. 1970-1976
-
-
Glynn, E.L.1
Fry, C.S.2
Drummond, M.J.3
-
30
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
DOI 10.2337/diabetes.54.9.2674
-
Tremblay F, Krebs M, Dombrowski L, et al. (2005) Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54, 2674-2684. (Pubitemid 41233590)
-
(2005)
Diabetes
, vol.54
, Issue.9
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhausl, W.8
Marette, A.9
Roden, M.10
-
31
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F & Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276, 38052-38060.
-
(2001)
J Biol Chem
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
32
-
-
79951673619
-
Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance
-
Balage M, Dupont J, Mothe-Satney I, et al. (2011) Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 22, 219-226.
-
(2011)
J Nutr Biochem
, vol.22
, pp. 219-226
-
-
Balage, M.1
Dupont, J.2
Mothe-Satney, I.3
-
33
-
-
33745853476
-
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
-
DOI 10.1152/ajpendo.00488.2005
-
Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. (2006) A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol 291, E381-E387. (Pubitemid 44035298)
-
(2006)
American Journal of Physiology - Endocrinology and Metabolism
, vol.291
, Issue.2
-
-
Katsanos, C.S.1
Kobayashi, H.2
Sheffield-Moore, M.3
Aarsland, A.4
Wolfe, R.R.5
-
34
-
-
33746876019
-
Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
-
DOI 10.1113/jphysiol.2006.110742
-
Rieu I, Balage M, Sornet C, et al. (2006) Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575, (Pt 1), 305-315. (Pubitemid 44182713)
-
(2006)
Journal of Physiology
, vol.575
, Issue.1
, pp. 305-315
-
-
Rieu, I.1
Balage, M.2
Sornet, C.3
Giraudet, C.4
Pujos, E.5
Grizard, J.6
Mosoni, L.7
Dardevet, D.8
-
35
-
-
65549171522
-
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
-
Verhoeven S, Vanschoonbeek K, Verdijk LB, et al. (2009) Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 89, 1468-1475.
-
(2009)
Am J Clin Nutr
, vol.89
, pp. 1468-1475
-
-
Verhoeven, S.1
Vanschoonbeek, K.2
Verdijk, L.B.3
-
36
-
-
14744267948
-
Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle
-
DOI 10.1002/jcp.20207
-
Lang CH & Frost RA (2005) Endotoxin disrupts the leucinesignaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol 203, 144-155. (Pubitemid 40328181)
-
(2005)
Journal of Cellular Physiology
, vol.203
, Issue.1
, pp. 144-155
-
-
Lang, C.H.1
Frost, R.A.2
-
37
-
-
4544362833
-
Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation
-
DOI 10.1152/ajpendo.00132.2004
-
Lang CH & Frost RA (2004) Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Am J Physiol 287, E721-E730. (Pubitemid 39237901)
-
(2004)
American Journal of Physiology - Endocrinology and Metabolism
, vol.287
, Issue.4
-
-
Lang, C.H.1
Frost, R.A.2
-
38
-
-
5444238912
-
Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats
-
DOI 10.1016/j.exger.2004.06.005, PII S0531556504001913
-
Rieu I, Sornet C, Grizard J, et al. (2004) Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats. Experi Gerontol 39, 1315-1321. (Pubitemid 39360372)
-
(2004)
Experimental Gerontology
, vol.39
, Issue.9
, pp. 1315-1321
-
-
Rieu, I.1
Sornet, C.2
Grizard, J.3
Dardevet, D.4
-
39
-
-
54749088342
-
Activation of AMP-activated protein kinase by 5-aminoimidazole-4- carboxamide- 1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle
-
Pruznak AM, Kazi AA, Frost RA, et al. (2008) Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide- 1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr 138, 1887-1894.
-
(2008)
J Nutr
, vol.138
, pp. 1887-1894
-
-
Pruznak, A.M.1
Kazi, A.A.2
Frost, R.A.3
|