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Volumn 108, Issue SUPPL. 2, 2012, Pages

New perspectives in the control of body protein metabolism

Author keywords

Leucine; Protein degradation; Protein metabolism; Protein synthesis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; INITIATION FACTOR 2; INITIATION FACTOR 4F; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA;

EID: 84868109679     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512002449     Document Type: Article
Times cited : (4)

References (39)
  • 1
    • 62549128139 scopus 로고    scopus 로고
    • A census of human transcription factors: Function, expression and evolution
    • Vaquerizas JM, Kummerfeld SK, Teichmann SA, et al. (2009) A census of human transcription factors: function, expression and evolution. Nat Rev 10, 252-263.
    • (2009) Nat Rev , vol.10 , pp. 252-263
    • Vaquerizas, J.M.1    Kummerfeld, S.K.2    Teichmann, S.A.3
  • 2
    • 50349087339 scopus 로고    scopus 로고
    • Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake
    • Malmberg SE & Adams CM (2008) Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem 283, 19229-19234.
    • (2008) J Biol Chem , vol.283 , pp. 19229-19234
    • Malmberg, S.E.1    Adams, C.M.2
  • 3
    • 0036789999 scopus 로고    scopus 로고
    • Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
    • Arantes VC, Teixeira VP, Reis MA, et al. (2002) Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation. J Nutr 132, 3030-3035.
    • (2002) J Nutr , vol.132 , pp. 3030-3035
    • Arantes, V.C.1    Teixeira, V.P.2    Reis, M.A.3
  • 4
    • 0017305263 scopus 로고
    • Obesity in young men after famine exposure in utero and early infancy
    • Ravelli GP, Stein ZA & Susser MW (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 7, 349-353.
    • (1976) N Engl J Med , vol.7 , pp. 349-353
    • Ravelli, G.P.1    Stein, Z.A.2    Susser, M.W.3
  • 5
    • 0036862451 scopus 로고    scopus 로고
    • Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
    • DOI 10.1038/sj.ejhg.5200859
    • Kaati G, Bygren LO & Edvinsson S (2002) Cardiovascular and diabetes mortality determined by nutrition during parents' and grand parents' slow growth period. Eur J Hum Genet 10, 682-688. (Pubitemid 35460575)
    • (2002) European Journal of Human Genetics , vol.10 , Issue.11 , pp. 682-688
    • Kaati, G.1    Bygren, L.O.2    Edvinson, S.3
  • 7
    • 0016824053 scopus 로고
    • Leucine. A possible regulator of protein turnover in muscle
    • Buse MG & Reid SS (1975) Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56, 1250-1261.
    • (1975) J Clin Invest , vol.56 , pp. 1250-1261
    • Buse, M.G.1    Reid, S.S.2
  • 8
    • 0016431688 scopus 로고
    • Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm
    • Fulks RM, Li JB & Goldberg AL (1975) Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250, 290-298.
    • (1975) J Biol Chem , vol.250 , pp. 290-298
    • Fulks, R.M.1    Li, J.B.2    Goldberg, A.L.3
  • 9
    • 0018128453 scopus 로고
    • Influence of amino acid availability on protein turnover in perfused skeletal muscle
    • Li JB & Jefferson LS (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochimica et Biophysica Acta 544, 351-359. (Pubitemid 9052911)
    • (1978) Biochimica et Biophysica Acta , vol.544 , Issue.2 , pp. 351-359
    • Li, J.B.1    Jefferson, L.S.2
  • 10
    • 0019197010 scopus 로고
    • Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects
    • Hagenfeldt L, Eriksson S & Wahren J (1980) Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clin Sci (Lond) 59, 173-181. (Pubitemid 11230848)
    • (1980) Clinical Science , vol.59 , Issue.3 , pp. 173-181
    • Hagenfeldt, L.1    Eriksson, S.2    Wahren, J.3
  • 11
    • 0020312363 scopus 로고
    • Failure of leucine to stimulate protein synthesis in vivo
    • McNurlan MA, Fern EB & Garlick PJ (1982) Failure of leucine to stimulate protein synthesis in vivo. Biochem J 204, 831-838. (Pubitemid 12009160)
    • (1982) Biochemical Journal , vol.204 , Issue.3 , pp. 831-838
    • McNurlan, M.A.1    Fern, E.B.2    Garlick, P.J.3
  • 12
    • 0019500769 scopus 로고
    • Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man
    • Mitch WE, Walser M & Sapir DG (1981) Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man. J Clin Invest 67, 553-562. (Pubitemid 11141739)
    • (1981) Journal of Clinical Investigation , vol.67 , Issue.2 , pp. 553-562
    • Mitch, W.E.1    Walser, M.2    Sapir, D.G.3
  • 13
    • 0017334005 scopus 로고
    • Nitrogen sparing induced early in starvation by infusion of branched chain ketoacids
    • DOI 10.1016/0026-0495(77)90077-4
    • Sapir DG & Walser M (1977) Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacids. Metab: Clin Experi 26, 301-308. (Pubitemid 8038161)
    • (1977) Metabolism: Clinical and Experimental , vol.26 , Issue.3 , pp. 301-308
    • Sapir, D.G.1    Walser, M.2
  • 14
    • 0017825464 scopus 로고
    • Effect of starvation on the turnover and metabolic response to leucine
    • Sherwin RS (1978) Effect of starvation on the turnover and metabolic response to leucine. J Clin Invest 61, 1471-1481. (Pubitemid 8361873)
    • (1978) Journal of Clinical Investigation , vol.61 , Issue.6 , pp. 1471-1481
    • Sherwin, R.S.1
  • 15
    • 0033980371 scopus 로고    scopus 로고
    • Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased elF4F formation
    • Anthony JC, Anthony TG, Kimball SR, et al. (2000) Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 130, 139-145. (Pubitemid 30073785)
    • (2000) Journal of Nutrition , vol.130 , Issue.2 , pp. 139-145
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Vary, T.C.4    Jefferson, L.S.5
  • 17
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
    • Anthony JC, Yoshizawa F, Anthony TG, et al. (2000) Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130, 2413-2419.
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3
  • 18
    • 78649544447 scopus 로고    scopus 로고
    • Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation
    • Murgas Torrazza R, Suryawan A, Gazzaneo MC, et al. (2010) Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr 140, 2145-2152.
    • (2010) J Nutr , vol.140 , pp. 2145-2152
    • Murgas Torrazza, R.1    Suryawan, A.2    Gazzaneo, M.C.3
  • 19
    • 0014735856 scopus 로고
    • Synergistic effect of certain amino acid pairs upon insulin secretion in man
    • Floyd JC Jr, Fajans SS, Pek S, et al. (1970) Synergistic effect of certain amino acid pairs upon insulin secretion in man. Diabetes 19, 102-108.
    • (1970) Diabetes , vol.19 , pp. 102-108
    • Floyd Jr., J.C.1    Fajans, S.S.2    Pek, S.3
  • 20
    • 0023723070 scopus 로고
    • Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids
    • Garlick PJ & Grant I (1988) Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J 254, 579-584.
    • (1988) Biochem J , vol.254 , pp. 579-584
    • Garlick, P.J.1    Grant, I.2
  • 21
    • 0036230645 scopus 로고    scopus 로고
    • Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    • Anthony JC, Reiter AK, Anthony TG, et al. (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51, 928-936. (Pubitemid 34438333)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 928-936
    • Anthony, J.C.1    Reiter, A.K.2    Anthony, T.G.3    Crozier, S.J.4    Lang, C.H.5    MacLean, D.A.6    Kimball, S.R.7    Jefferson, L.S.8
  • 23
    • 0034830022 scopus 로고    scopus 로고
    • Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
    • Greiwe JS, Kwon G, McDaniel ML, et al. (2001) Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. Am J Physiol 281, E466-E471.
    • (2001) Am J Physiol , vol.281
    • Greiwe, J.S.1    Kwon, G.2    McDaniel, M.L.3
  • 25
    • 79960621627 scopus 로고    scopus 로고
    • The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus
    • Desikan V, Mileva I, Garlick J, et al. (2010) The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus. Int J Pediatr Endocrinol 2010, 493258.
    • (2010) Int J Pediatr Endocrinol 2010 , pp. 493258
    • Desikan, V.1    Mileva, I.2    Garlick, J.3
  • 26
    • 77953040366 scopus 로고    scopus 로고
    • Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases
    • Baptista IL, Leal ML, Artioli GG, et al. (2010) Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle Nerve 41, 800-808.
    • (2010) Muscle Nerve , vol.41 , pp. 800-808
    • Baptista, I.L.1    Leal, M.L.2    Artioli, G.G.3
  • 27
    • 70349604105 scopus 로고    scopus 로고
    • Regulation of muscle protein degradation, not synthesis by dietary leucine in rats fed a protein-deficient diet
    • Sugawara T, Ito Y, Nishizawa N, et al. (2009) Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet. Amino Acids 37, 609-616.
    • (2009) Amino Acids , vol.37 , pp. 609-616
    • Sugawara, T.1    Ito, Y.2    Nishizawa, N.3
  • 28
    • 0028878309 scopus 로고
    • Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle
    • Biolo G, Fleming RY, Maggi SP, et al. (1995) Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol 268, (1 Pt 1), E75-E84.
    • (1995) Am J Physiol , vol.268 , Issue.1 PART 1
    • Biolo, G.1    Fleming, R.Y.2    Maggi, S.P.3
  • 29
    • 78149245600 scopus 로고    scopus 로고
    • Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
    • Glynn EL, Fry CS, Drummond MJ, et al. (2010) Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140, 1970-1976.
    • (2010) J Nutr , vol.140 , pp. 1970-1976
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3
  • 31
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F & Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276, 38052-38060.
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 32
    • 79951673619 scopus 로고    scopus 로고
    • Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance
    • Balage M, Dupont J, Mothe-Satney I, et al. (2011) Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. J Nutr Biochem 22, 219-226.
    • (2011) J Nutr Biochem , vol.22 , pp. 219-226
    • Balage, M.1    Dupont, J.2    Mothe-Satney, I.3
  • 34
  • 35
    • 65549171522 scopus 로고    scopus 로고
    • Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
    • Verhoeven S, Vanschoonbeek K, Verdijk LB, et al. (2009) Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 89, 1468-1475.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1468-1475
    • Verhoeven, S.1    Vanschoonbeek, K.2    Verdijk, L.B.3
  • 36
    • 14744267948 scopus 로고    scopus 로고
    • Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle
    • DOI 10.1002/jcp.20207
    • Lang CH & Frost RA (2005) Endotoxin disrupts the leucinesignaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol 203, 144-155. (Pubitemid 40328181)
    • (2005) Journal of Cellular Physiology , vol.203 , Issue.1 , pp. 144-155
    • Lang, C.H.1    Frost, R.A.2
  • 37
    • 4544362833 scopus 로고    scopus 로고
    • Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation
    • DOI 10.1152/ajpendo.00132.2004
    • Lang CH & Frost RA (2004) Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Am J Physiol 287, E721-E730. (Pubitemid 39237901)
    • (2004) American Journal of Physiology - Endocrinology and Metabolism , vol.287 , Issue.4
    • Lang, C.H.1    Frost, R.A.2
  • 38
    • 5444238912 scopus 로고    scopus 로고
    • Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats
    • DOI 10.1016/j.exger.2004.06.005, PII S0531556504001913
    • Rieu I, Sornet C, Grizard J, et al. (2004) Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats. Experi Gerontol 39, 1315-1321. (Pubitemid 39360372)
    • (2004) Experimental Gerontology , vol.39 , Issue.9 , pp. 1315-1321
    • Rieu, I.1    Sornet, C.2    Grizard, J.3    Dardevet, D.4
  • 39
    • 54749088342 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by 5-aminoimidazole-4- carboxamide- 1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle
    • Pruznak AM, Kazi AA, Frost RA, et al. (2008) Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide- 1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr 138, 1887-1894.
    • (2008) J Nutr , vol.138 , pp. 1887-1894
    • Pruznak, A.M.1    Kazi, A.A.2    Frost, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.