Gene expression changes in human islets exposed to type 1 diabetic serum

Islets

Volumn 4, Issue 4, 2012, Pages 312-319

  Jackson, Andrew M ^a,e   Kanak, Mazhar A ^a   Grishman, Ellen K ^b   Chaussabel, Damien ^c   Levy, Marlon F ^d   Naziruddin, Bashoo ^a,d  

^a BAYLOR UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

^d BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Complement; Inflammation; Islet cell transplantation; Microarray

Indexed keywords

EID: 84868108183     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.21510     Document Type: Article

References (42)

1. Shapiro AMJ, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a gluco-corticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230-8; PMID:10911004; http://dx.doi.org/10.1056/NEJM200007273430401. (Pubitemid 30490390)
2. Shapiro AMJ, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson R P, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355:1318-30; PMID:17005949; http://dx.doi.org/10.1056/NEJMoa061267. (Pubitemid 44465460)
3. Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54:2060-9; PMID:15983207; http://dx.doi.org/10.2337/diabetes.54.7.2060. (Pubitemid 40911269)
4. Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005; 293:830-5; PMID:15713772; http://dx.doi.org/10.1001/jama. 293.7.830. (Pubitemid 40250366)
5. Bennet W, Sundberg B, Groth CG, Brendel MD, Brandhorst D, Brandhorst H, et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes 1999; 48:1907-14; PMID:10512353; http://dx.doi.org/10.2337/diabe-tes. 48.10.1907.
6. Goto M, Johansson H, Maeda A, Elgue G, Korsgren O, Nilsson B. Low molecular weight dextran sulfate prevents the instant blood-mediated inflammatory reaction induced by adult porcine islets. Transplantation 2004; 77:741-7; PMID:15021838; http://dx.doi.org/10.1097/01.TP.0000114872.26990.4F. (Pubitemid 38366981)
7. Goto M, Johansson H, Maeda A, Elgue G, Korsgren O, Nilsson B. Low-molecular weight dextran sul-fate abrogates the instant blood-mediated inflammatory reaction induced by adult porcine islets both in vitro and in vivo. Transplant Proc 2004; 36:1186-7; PMID:15194411; http://dx.doi.org/10.1016/j. transproceed.2004.04.028. (Pubitemid 38766317)
8. Johansson H, Goto M, Dufrane D, Siegbahn A, Elgue G, Gianello P, et al. Low molecular weight dextran sul-fate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant 2006; 6:305-12; PMID:16426314; http://dx.doi.org/10.1111/j.1600-6143.2005.01186.x. (Pubitemid 43382165)
9. Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 2005; 54:1755-62; PMID:15919797; http://dx.doi.org/10.2337/diabetes.54.6.1755. (Pubitemid 40770765)
10. Moberg L, Johansson H, Lukinius A, Berne C, Foss A, Källen R, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental throm-botic reactions in clinical islet transplantation. Lancet 2002; 360:2039-45; PMID:12504401; http://dx.doi.org/10.1016/S0140-6736(02)12020- 4. (Pubitemid 36026584)
11. Moberg L, Korsgren O, Nilsson B. Neutrophilic granu-locytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood. Clin Exp Immunol 2005; 142:125-31; PMID:16178866; http://dx.doi.org/10.1111/j.1365-2249.2005.02883.x. (Pubitemid 41361015)
12. Moberg L, Olsson A, Berne C, Felldin M, Foss A, Källen R, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation 2003; 76:1285-8; PMID:14627904; http://dx.doi.org/10.1097/01.TP.0000098905.86445.0F. (Pubitemid 37430712)
13. Özmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B. Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 2002; 51:1779-84; PMID:12031965; http://dx.doi.org/10.2337/diabe-tes.51.6.1779. (Pubitemid 34564290)
14. Tjernberg J, Ekdahl KN, Lambris JD, Korsgren O, Nilsson B. Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation 2008; 85:1193-9; PMID:18431241; http://dx.doi.org/10.1097/TP. 0b013e31816b22f3. (Pubitemid 351590198)
15. Jackson A, McWilliams C, Kaizer E, Chaussabel D, Glaser C, Noguchi H, et al. Gene expression profiling of human pancreatic islets undergoing a simulated process of instant blood-mediated inflammatory reaction. Transplant Proc 2008; 40:430-2; PMID:18374091; http://dx.doi.org/10.1016/j.transproceed.2008.01.021. (Pubitemid 351406414)
16. Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl KN, et al. Dissecting the instant blood-mediated inflammatory reaction in islet xenotrans-plantation. Xenotransplantation 2008; 15:225-34; PMID:18957045; http://dx.doi.org/10.1111/j.1399-3089.2008.00482.x.
17. Contreras JL, Eckstein C, Smyth CA, Sellers M T, Vilatoba M, Bilbao G, et al. Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. Diabetes 2003; 52:2935-42; PMID:14633854; http://dx.doi.org/10.2337/diabetes.52.12.2935. (Pubitemid 37466863)
18. Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007; 92:3705-11; PMID:17595242; http://dx.doi.org/10.1210/jc.2007-0979. (Pubitemid 47435359)
19. Kannel WB, D'Agostino RB, Wilson PWF, Belanger AJ, Gagnon DR. Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience. Am Heart J 1990; 120:672-6; PMID:2389702; http://dx.doi.org/10.1016/0002-8703(90) 90026-T. (Pubitemid 20312600)
20. Lechleitner M, Koch T, Herold M, Dzien A, Hoppichler F. Tumour necrosis factor-alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and cardiovascular risk factors. J Intern Med 2000; 248:67-76; PMID:10947883; http://dx.doi.org/10.1046/j.1365-2796.2000. 00705.x. (Pubitemid 30470006)
21. Roach JC, Smith KD, Strobe KL, Nissen SM, Haudenschild CD, Zhou D, et al. Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells. Proc Natl Acad Sci USA 2007; 104:16245-50; PMID:17913878; http://dx.doi.org/10.1073/pnas.0707757104. (Pubitemid 350099392)
22. Osman M, Tortorella M, Londei M, Quaratino S. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases define the migratory characteristics of human monocyte-derived dendritic cells. Immunology 2002; 105:73-82; PMID:11849317; http://dx.doi.org/10.1046/j.0019-2805.2001. 01349.x. (Pubitemid 34128042)
23. Barro C, Zaoui P, Morel F, Benhamou PY. Matrix metalloproteinase expression in rat pancreatic islets. Pancreas 1998; 17:378-82; PMID:9821179; http://dx.doi.org/10.1097/00006676-199811000-00008. (Pubitemid 28516093)
24. Olsson R, Maxhuni A, Carlsson PO. Revascularization of transplanted pancreatic islets following culture with stimulators of angiogenesis. Transplantation 2006; 82:340-7; PMID:16906031; http://dx.doi.org/10.1097/01.tp. 0000229418.60236.87. (Pubitemid 44223032)
25. Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, et al. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci USA 2003; 100:2645-50; PMID:12598651; http://dx.doi.org/10.1073/pnas. 0437939100. (Pubitemid 36297552)
26. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and β-amyloid precursor protein. Cell 2002; 110:55-67; PMID:12150997; http://dx.doi.org/10.1016/S0092-8674(02)00809-7. (Pubitemid 34874606)
27. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM Jr., et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA 1990; 87:7512-6; PMID:2145578; http://dx.doi.org/10.1073/pnas.87.19.7512. (Pubitemid 20341746)
28. Du XX, Williams DA. Interleukin-11: a multifunctional growth factor derived from the hematopoi-etic microenvironment. Blood 1994; 83:2023-30; PMID:7512836. (Pubitemid 24112711)
29. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-25; PMID:11114383; http://dx.doi.org/10.1016/S1074-7613(00)00070-4.
30. Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, et al. IL-23 promotes tumour incidence and growth. Nature 2006; 442:461-5; PMID:16688182; http://dx.doi.org/10.1038/nature04808. (Pubitemid 44264796)
31. Reynet C, Kahn CR. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science 1993; 262:1441-4; PMID:8248782; http://dx.doi.org/10.1126/science.8248782. (Pubitemid 24035065)
32. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 1997; 385:544-8; PMID:9020362; http://dx.doi.org/10.1038/385544a0. (Pubitemid 27074674)
33. Vojtek AB, Der CJ. Increasing complexity of the Ras signaling pathway. J Biol Chem 1998; 273:19925-8; PMID:9685325; http://dx.doi.org/10.1074/jbc.273.32. 19925. (Pubitemid 28377538)
34. Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, et al. Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets. Proc Natl Acad Sci USA 2004; 101:8138-43; PMID:15141093; http://dx.doi.org/10.1073/pnas.0305683101. (Pubitemid 38698067)
35. Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007; 356:1517-26; PMID:17429083; http://dx.doi.org/10.1056/NEJMoa065213. (Pubitemid 46588416)
36. Papaccio G, Graziano A, D'Aquino R, Valiante S, Naro F. A biphasic role of nuclear transcription factor (NF)-kappaB in the islet β-cell apoptosis induced by interleukin (IL)-1β. J Cell Physiol 2005; 204:124-30; PMID:15622524; http://dx.doi.org/10.1002/jcp.20276. (Pubitemid 40776814)
37. Tabatabaie T, Vasquez-Weldon A, Moore DR, Kotake Y. Free radicals and the pathogenesis of type 1 diabetes: beta-cell cytokine-mediated free radical generation via cyclooxy-genase-2. Diabetes 2003; 52:1994-9; PMID:12882915; http://dx.doi.org/10.2337/diabetes.52.8.1994. (Pubitemid 36919791)
38. Wilson GL, Patton NJ, LeDoux S P. Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide. Diabetes 1997; 46:1291-5; PMID:9231653; http://dx.doi.org/10.2337/diabetes.46.8.1291. (Pubitemid 27315277)
39. Kuroda Y, Fujino Y, Morita A, Tanioka Y, Ku Y, Saitoh Y. Oxygenation of the human pancreas during preservation by a two-layer (University of Wisconsin solution/perfluorochemical) cold-storage method. Transplantation 1992; 54:561-2; PMID:1412741; http://dx.doi.org/10.1097/00007890-199209000-00036.
40. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37:413-20; PMID:3288530; http://dx.doi.org/10.2337/diabetes.37.4.413. (Pubitemid 18096377)
41. Kin T, Senior P, O'Gorman D, Richer B, Salam A, Shapiro AMJ. Risk factors for islet loss during culture prior to transplantation. Transpl Int 2008; 21:1029-35; PMID:18564983.
42. Allantaz F, Chaussabel D, Stichweh D, Bennett L, Allman W, Mejias A, et al. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med 2007; 204:2131-44; PMID:17724127; http://dx.doi.org/10.1084/jem.20070070. (Pubitemid 47360874)