Active tuberculosis is characterized by an antigen specific and strictly localized expansion of effector T cells at the site of infection

European Journal of Immunology

Volumn 42, Issue 11, 2012, Pages 2844-2850

  Nemeth, Johannes ^a,c   Rumetshofer, Rudolf ^b   Winkler, Heide Maria ^a   Burghuber, Otto C ^b   Müller, Catharina ^a   Winkler, Stefan ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b OTTO WAGNER HOSPITAL   (Austria)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Effector T cell; Memory T cell; Tuberculosis

Indexed keywords

CD27 ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYSTEINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON;

ADULT; AGED; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; ASCITES; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUBERCULOSIS; TUBERCULOUS PLEURISY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; ANTIGENS, CD27; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, CCR7; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTE SUBSETS; TUBERCULIN; TUBERCULOSIS;

EID: 84868101794     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242678     Document Type: Article

References (11)

1. Sester, M., Sotgiu, G., Lange, C., Giehl, C., Girardi, E., Migliori, G. B., Bossink, A., et al. Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur. Respir. J. 2011. 37: 100-111.
2. Nemeth, J., Winkler, H. M., Zwick, R. H., Rumetshofer, R., Schenk, P., Burghuber, O. C., Graninger, W. and Winkler, S., Recruitment of Mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis. J. Intern. Med. 2009. 265: 163-168.
3. Nemeth, J., Winkler, H. M., Boeck, L., Adegnika, A. A., Clement, E., Mve, T. M., Kremsner, P. G. and Winkler, S., Specific cytokine patterns of pulmonary tuberculosis in Central Africa. Clin. Immunol. 2011. 138: 50-59.
4. Sallusto, F., Geginat, J. and Lanzavecchia, A., Central memory and effector memory T-cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745-763.
5. Fritsch, R. D., Shen, X., Sims, G. P., Hathcock, K. S., Hodes, R. J. and Lipsky, P. E., Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J. Immunol. 2005. 175: 6489-6497.
6. Merkenschlager, M., Terry, L., Edwards, R. and Beverley, P. C., Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T-cell memory formation. Eur. J. Immunol. 1988. 18: 1653-1661.
7. Kapina, M. A., Shepelkova, G. S., Mischenko, V. V., Sayles, P., Bogacheva, P., Winslow, G., Apt, A. S. and Lyadova, I. V., CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27 high precursors in situ, produce IFN-gamma, and protect the host against tuberculosis infection. J. Immunol. 2007. 178: 976-985.
8. Nambiar, J. K., Pinto, R., Aguilo, J. I., Takatsu, K., Martin, C., Britton, W. J. and Triccas, J. A., Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. Eur. J. Immunol. 2012. 42: 385-392.
9. Streitz, M., Tesfa, L., Yildirim, V., Yahyazadeh, A., Ulrichs, T., Lenkei, R., Quassem, A., et al., Loss of receptor on tuberculin-reactive T-cells marks active pulmonary tuberculosis. PLoS One 2007. 2: e735.
10. Nemeth, J., Winkler, H. M., Zwick, R. H., Müller, C., Rumetshofer, R., Boeck, L., Burghuber, O. C. and Winkler, S., Peripheral T-cell cytokine responses for diagnosis of active tuberculosis. PLoS One 2012. 7: e35290.
11. Zinkernagel, R. M. and Hengartner, H., Regulation of the immune response by antigen. Science 2001. 293: 251-253.