-
1
-
-
63349086953
-
The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing
-
Deweese JE, Osheroff N. The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing. Nucleic Acids Res 2009;37:738-748.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 738-748
-
-
Deweese, J.E.1
Osheroff, N.2
-
2
-
-
0042208398
-
The HER-2/neu gene and protein in breast cancer 2003: Biomarker and target of therapy
-
Ross JS, Fletcher JA, Linette GP et al. The HER-2/neu gene and protein in breast cancer 2003: Biomarker and target of therapy. The Oncologist 2003;8:307-325.
-
(2003)
The Oncologist
, vol.8
, pp. 307-325
-
-
Ross, J.S.1
Fletcher, J.A.2
Linette, G.P.3
-
4
-
-
20944439542
-
The incidence of topoisomerase II-α genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: A fluorescence in situ hybridization study
-
Hicks DG, Yoder BJ, Pettay J et al. The incidence of topoisomerase II-α genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: A fluorescence in situ hybridization study. Hum Pathol 2005;36:348-356.
-
(2005)
Hum Pathol
, vol.36
, pp. 348-356
-
-
Hicks, D.G.1
Yoder, B.J.2
Pettay, J.3
-
5
-
-
0043145754
-
Characterization of topoisomerase II α gene amplification and deletion in breast cancer
-
Järvinen TA, Tanner M, BärlundMet al. Characterization of topoisomerase II α gene amplification and deletion in breast cancer. Genes Chromosomes Cancer 1999;26:142-150.
-
(1999)
Genes Chromosomes Cancer
, vol.26
, pp. 142-150
-
-
Järvinen, T.A.1
Tanner, M.2
Bärlund, M.3
-
6
-
-
77949267066
-
Aberrations of ERBB2 and TOP2A genes in breast cancer
-
Nielsen KV, Ml̈ler S, Mller S et al. Aberrations of ERBB2 and TOP2A genes in breast cancer. Mol Oncol 2010;4:161-168.
-
(2010)
Mol Oncol
, vol.4
, pp. 161-168
-
-
Nielsen, K.V.1
Ml̈ler, S.2
Mller, S.3
-
7
-
-
0036091354
-
HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracyclinebased therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
-
Di Leo A, Gancberg D, Larsimont D et al. HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracyclinebased therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res 2002;8:1107-1116.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1107-1116
-
-
Di Leo, A.1
Gancberg, D.2
Larsimont, D.3
-
8
-
-
79952323665
-
Alteration of topoisomerase II-α gene in human breast cancer: Association with responsiveness to anthracycline-based chemotherapy
-
Press MF, Sauter G, Buyse M et al. Alteration of topoisomerase II-α gene in human breast cancer: Association with responsiveness to anthracycline-based chemotherapy. J Clin Oncol 2011;29:859-867.
-
(2011)
J Clin Oncol
, vol.29
, pp. 859-867
-
-
Press, M.F.1
Sauter, G.2
Buyse, M.3
-
9
-
-
81255129146
-
HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: A meta-analysis of individual patient data
-
Di Leo A, Desmedt C, Bartlett JM et al. HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: A meta-analysis of individual patient data. Lancet Oncol 2011;12:1134-1142.
-
(2011)
Lancet Oncol
, vol.12
, pp. 1134-1142
-
-
Di Leo, A.1
Desmedt, C.2
Bartlett, J.M.3
-
10
-
-
32944475493
-
Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
-
Knoop AS, Knudsen H, Balslev E et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 2005;23:7483-7490.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7483-7490
-
-
Knoop, A.S.1
Knudsen, H.2
Balslev, E.3
-
11
-
-
65549158566
-
Topoisomerase II α and responsiveness of breast cancer to adjuvant chemotherapy
-
O'Malley FP, Chia S, Tu D et al. Topoisomerase II α and responsiveness of breast cancer to adjuvant chemotherapy. J Natl Cancer Inst 2009;101:644-650.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 644-650
-
-
O'Malley, F.P.1
Chia, S.2
Tu, D.3
-
12
-
-
33744969590
-
Topoisomerase IIα gene amplification predicts favorable treatment response to tailored and dose-escalated anthracyclinebased adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401
-
Tanner M, Isola J, Wiklund T et al. Topoisomerase IIα gene amplification predicts favorable treatment response to tailored and dose-escalated anthracyclinebased adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J Clin Oncol 2006;24:2428-2436.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2428-2436
-
-
Tanner, M.1
Isola, J.2
Wiklund, T.3
-
13
-
-
77953725585
-
Clinical evaluation of developed PCR-based method with hydrolysis probes for TOP2A copy number evaluation in breast cancer samples
-
Zaczek A, Markiewicz A, Jaskiewicz J et al. Clinical evaluation of developed PCR-based method with hydrolysis probes for TOP2A copy number evaluation in breast cancer samples. Clin Biochem 2010;43:891-898.
-
(2010)
Clin Biochem
, vol.43
, pp. 891-898
-
-
Zaczek, A.1
Markiewicz, A.2
Jaskiewicz, J.3
-
14
-
-
0033870292
-
Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
-
Järvinen T, Tanner M, Rantanen V et al. Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol 2000;156:839-847.
-
(2000)
Am J Pathol
, vol.156
, pp. 839-847
-
-
Järvinen, T.1
Tanner, M.2
Rantanen, V.3
-
15
-
-
1442265950
-
Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes
-
Olsen KE, Knudsen H, Rasmussen BB et al. Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes. Acta Oncol 2004;43:35-42.
-
(2004)
Acta Oncol
, vol.43
, pp. 35-42
-
-
Olsen, K.E.1
Knudsen, H.2
Rasmussen, B.B.3
-
16
-
-
77951019861
-
ERBB2 and TOP2A in breast cancer: A comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction
-
Brase JC, Schmidt M, Fischbach T et al. ERBB2 and TOP2A in breast cancer: A comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clin Cancer Res 2010;16:2391-2401.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2391-2401
-
-
Brase, J.C.1
Schmidt, M.2
Fischbach, T.3
-
17
-
-
84868157877
-
-
London: Pharmaceutical Press
-
Durham TA, Turner JR. Probability, Hypothesis Testing, and Estimation, Introduction to Statistics in Pharmaceutical Clinical Trials. London: Pharmaceutical Press, 2008:1-240.
-
(2008)
Probability, Hypothesis Testing, and Estimation, Introduction to Statistics in Pharmaceutical Clinical Trials
, pp. 1-240
-
-
Durham, T.A.1
Turner, J.R.2
-
18
-
-
84868347231
-
Prognostic value of TOP2A gene amplification and chromosome 17 polysomy in early breast cancer
-
Zaczek A, Markiewicz A, Supernat A et al. Prognostic value of TOP2A gene amplification and chromosome 17 polysomy in early breast cancer. Pathol Oncol Res 2012 Mar 18 [Epub ahead of print].
-
(2012)
Pathol Oncol Res Mar
, pp. 18
-
-
Zaczek, A.1
Markiewicz, A.2
Supernat, A.3
-
19
-
-
17944375163
-
Her-2 and topo-isomerase IIα as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide
-
Di Leo A, Larsimont D, Gancberg D et al. Her-2 and topo-isomerase IIα as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. Ann Oncol 2001;12:1081-1089.
-
(2001)
Ann Oncol
, vol.12
, pp. 1081-1089
-
-
Di Leo, A.1
Larsimont, D.2
Gancberg, D.3
-
20
-
-
34447298245
-
Topoisomerase II α amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer
-
Arriola E, Rodriguez-Pinilla SM, Lambros MB et al. Topoisomerase II α amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer. Breast Cancer Res Treat 2007;106:181-189.
-
(2007)
Breast Cancer Res Treat
, vol.106
, pp. 181-189
-
-
Arriola, E.1
Rodriguez-Pinilla, S.M.2
Lambros, M.B.3
-
21
-
-
79953659342
-
Assessment of topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization
-
Romero A, Martín M, Cheang MC et al. Assessment of topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization. Am J Pathol 2011;178:1453-1460.
-
(2011)
Am J Pathol
, vol.178
, pp. 1453-1460
-
-
Romero, A.1
Martín, M.2
Cheang, M.C.3
-
22
-
-
19644388869
-
HER-2/neu and topoisomerase IIα gene amplification and protein expression in invasive breast carcinomas: Chromogenic in situ hybridization and immunohistochemical analyses
-
Bhargava R, Lal P, Chen B. HER-2/neu and topoisomerase IIα gene amplification and protein expression in invasive breast carcinomas: chromogenic in situ hybridization and immunohistochemical analyses. Am J Clin Pathol 2005;123:889-895.
-
(2005)
Am J Clin Pathol
, vol.123
, pp. 889-895
-
-
Bhargava, R.1
Lal, P.2
Chen, B.3
-
23
-
-
77950691127
-
Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer
-
Konecny GE, Pauletti G, Untch M et al. Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer. Breast Cancer Res Treat 2010; 120:481-489.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 481-489
-
-
Konecny, G.E.1
Pauletti, G.2
Untch, M.3
-
24
-
-
33746875523
-
Topoisomerase II-α gene deletion is not frequent as its amplification in breast cancer
-
Park K, Han S, GwakGHet al. Topoisomerase II-α gene deletion is not frequent as its amplification in breast cancer. Breast Cancer Res Treat 2006;98:337-342.
-
(2006)
Breast Cancer Res Treat
, vol.98
, pp. 337-342
-
-
Park, K.1
Han, S.2
Gwak, G.H.3
-
25
-
-
84879413989
-
-
Patent Application Publication, International Application No PCT/US2006/047732. Wigler MH, Hicks JB, Norton L, et al. Patent Application Publication, 2007. Available at accessed August 2, 2012
-
Patent Application Publication, International Application No PCT/US2006/047732. Wigler MH, Hicks JB, Norton L, et al. Use of ROMA for characterizing genomic rearrangements. Patent Application Publication, 2007. Available at http://patentscope.wipo.int/search/en/detail.jsf?docId_WO2007070640&recNum_ 1&maxRec_&office_&prevFilter_&sortOption_ &queryString_&tab_PCT_Biblio, accessed August 2, 2012.
-
Use of ROMA for characterizing genomic rearrangements
-
-
-
26
-
-
79960881389
-
TOP2A amplification in the absence of that of HER-2/neu: Toward individualization of chemotherapeutic practice in breast cancer
-
Glynn RW, Mahon S, Curran C et al. TOP2A amplification in the absence of that of HER-2/neu: Toward individualization of chemotherapeutic practice in breast cancer. The Oncologist 2011;16:949-955.
-
(2011)
The Oncologist
, vol.16
, pp. 949-955
-
-
Glynn, R.W.1
Mahon, S.2
Curran, C.3
-
27
-
-
58549106588
-
Gene expression of topoisomerase II α (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer
-
Rody A, Karn T, Ruckhäberle E et al. Gene expression of topoisomerase II α (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer. Breast Cancer Res Treat 2009; 113:457-466.
-
(2009)
Breast Cancer Res Treat
, vol.113
, pp. 457-466
-
-
Rody, A.1
Karn, T.2
Ruckhäberle, E.3
-
28
-
-
73349122284
-
Relationship between topoisomerase 2a RNA expression and recurrence after adjuvant chemotherapy for breast cancer
-
Sparano JA, Goldstein LJ, Childs BH et al. Relationship between topoisomerase 2a RNA expression and recurrence after adjuvant chemotherapy for breast cancer. Clin Cancer Res 2009;15:7693-7700.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7693-7700
-
-
Sparano, J.A.1
Goldstein, L.J.2
Childs, B.H.3
-
29
-
-
70249085601
-
Topoisomerase IIα amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: Results of CALGB 8541/150013
-
Harris LN, Broadwater G, Abu-KhalafMet al. Topoisomerase IIα amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: Results of CALGB 8541/150013. J Clin Oncol 2009;27:3430-3436.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3430-3436
-
-
Harris, L.N.1
Broadwater, G.2
Abu-Khalaf, M.3
-
30
-
-
65549112480
-
Alterations in the TOP2 and HER2 genes: Association with adjuvant anthracycline sensitivity in human breast cancers
-
Slamon DJ, Press MF. Alterations in the TOP2 and HER2 genes: Association with adjuvant anthracycline sensitivity in human breast cancers. J Natl Cancer Inst 2009;101:615-618.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 615-618
-
-
Slamon, D.J.1
Press, M.F.2
-
31
-
-
0027463825
-
Prognostic significance of a formalin-resistant nuclear proliferation antigen in mammary carcinomas as determined by the monoclonal antibody Ki-S1
-
Kreipe H, Alm P, Olsson H et al. Prognostic significance of a formalin-resistant nuclear proliferation antigen in mammary carcinomas as determined by the monoclonal antibody Ki-S1. Am J Pathol 1993;142: 651-657.
-
(1993)
Am J Pathol
, vol.142
, pp. 651-657
-
-
Kreipe, H.1
Alm, P.2
Olsson, H.3
-
32
-
-
0036949989
-
Prognostic significance of DNA topoisomerase II-α (Ki-S1) immunoexpression in endometrial carcinoma
-
Bildrici K, Tel N, Ozalp SS et al. Prognostic significance of DNA topoisomerase II-α (Ki-S1) immunoexpression in endometrial carcinoma. Eur J Gynaecol Oncol 2002;23:540-544.
-
(2002)
Eur J Gynaecol Oncol
, vol.23
, pp. 540-544
-
-
Bildrici, K.1
Tel, N.2
Ozalp, S.S.3
-
33
-
-
84855568731
-
HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy
-
Fountzilas G, Valavanis C, Kotoula V et al. HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. J Transl Med 2012;10:10.
-
(2012)
J Transl Med
, vol.10
, pp. 10
-
-
Fountzilas, G.1
Valavanis, C.2
Kotoula, V.3
-
34
-
-
1542343905
-
Amplification of the TOP2A gene does not predict high levels of topoisomerase II α protein in human breast tumor samples
-
Mueller RE, Parkes RK, Andruli I et al. Amplification of the TOP2A gene does not predict high levels of topoisomerase II α protein in human breast tumor samples. Genes Chromosomes Cancer 2004;39:288-297.
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 288-297
-
-
Mueller, R.E.1
Parkes, R.K.2
Andruli, I.3
-
35
-
-
74849138869
-
Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification
-
Moelans CB, de Weger RA, van Diest PJ. Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification. Breast Cancer Res Treat 2010;120:1-7.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 1-7
-
-
Moelans, C.B.1
de Weger, R.A.2
van Diest, P.J.3
-
36
-
-
84860389595
-
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers
-
Lamy PJ, Fina F, Bascoul-Mollevi C et al. Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers. Breast Cancer Res 2011;13:R15.
-
(2011)
Breast Cancer Res
, vol.13
-
-
Lamy, P.J.1
Fina, F.2
Bascoul-Mollevi, C.3
-
37
-
-
0033872068
-
Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction
-
Lehmann U, Glöckner S, Kleeberger W et al. Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction. Am J Pathol 2000;156:1855-1864.
-
(2000)
Am J Pathol
, vol.156
, pp. 1855-1864
-
-
Lehmann, U.1
Glöckner, S.2
Kleeberger, W.3
-
38
-
-
45149122291
-
The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D
-
Nielsen KV, Ejlertsen B, Mller S et al. The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D. Acta Oncol 2008;47:725-734.
-
(2008)
Acta Oncol
, vol.47
, pp. 725-734
-
-
Nielsen, K.V.1
Ejlertsen, B.2
Mller, S.3
|