메뉴 건너뛰기




Volumn 27, Issue 11, 2012, Pages 2115-2122

Deferasirox-induced renal impairment in children: An increasing concern for pediatricians

Author keywords

Children; Deferasirox; Drug nephrotoxicity; Glomerular filtration rate; Iron chelating agent; Proximal tubular toxicity

Indexed keywords

CREATININE; DEFERASIROX; FERRITIN;

EID: 84868095309     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-012-2170-4     Document Type: Article
Times cited : (38)

References (42)
  • 1
    • 36849072425 scopus 로고    scopus 로고
    • Iron loading and its clinical implications
    • 17963253 10.1002/ajh.21070 1:CAS:528:DC%2BD1cXhvFCksg%3D%3D
    • Hershko C (2007) Iron loading and its clinical implications. Am J Hematol 82:1147-1148
    • (2007) Am J Hematol , vol.82 , pp. 1147-1148
    • Hershko, C.1
  • 2
    • 36849089638 scopus 로고    scopus 로고
    • Concepts and goals in the management of transfusional iron overload
    • 17968973 10.1002/ajh.21100 1:CAS:528:DC%2BD1cXhvFClug%3D%3D
    • Porter JB (2007) Concepts and goals in the management of transfusional iron overload. Am J Hematol 82:1136-1139
    • (2007) Am J Hematol , vol.82 , pp. 1136-1139
    • Porter, J.B.1
  • 3
    • 36248992370 scopus 로고    scopus 로고
    • Deferasirox for transfusion-related iron overload: A clinical review
    • 18042472 10.1016/j.clinthera.2007.10.015 1:CAS:528:DC%2BD2sXhsVygtrfO
    • Lindsey WT, Olin BR (2007) Deferasirox for transfusion-related iron overload: a clinical review. Clin Ther 29:2154-2166
    • (2007) Clin Ther , vol.29 , pp. 2154-2166
    • Lindsey, W.T.1    Olin, B.R.2
  • 4
    • 34548708556 scopus 로고    scopus 로고
    • Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: A literature review
    • 17880620 10.1111/j.1537-2995.2007.01416.x 1:CAS:528:DC%2BD2sXht1elsrnN
    • Delea TE, Edelsberg J, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD (2007) Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion 47:1919-1929
    • (2007) Transfusion , vol.47 , pp. 1919-1929
    • Delea, T.E.1    Edelsberg, J.2    Sofrygin, O.3    Thomas, S.K.4    Baladi, J.F.5    Phatak, P.D.6    Coates, T.D.7
  • 7
    • 65349152022 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: The ESCALATOR study
    • 19187278 10.1111/j.1600-0609.2009.01228.x 1:CAS:528:DC%2BD1MXmtVyls7g%3D
    • Taher A, El-Beshlawy A, Elalfy MS, Al Zir K, Daar S, Habr D, Kriemler-Krahn U, Hmissi A, Al Jefri A (2009) Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study. Eur J Haematol 82:458-465
    • (2009) Eur J Haematol , vol.82 , pp. 458-465
    • Taher, A.1    El-Beshlawy, A.2    Elalfy, M.S.3    Al Zir, K.4    Daar, S.5    Habr, D.6    Kriemler-Krahn, U.7    Hmissi, A.8    Al Jefri, A.9
  • 9
    • 57049084100 scopus 로고    scopus 로고
    • Long-term efficacy and safety of deferasirox
    • 19059055 10.1016/S0268-960X(08)70007-9 1:CAS:528:DC%2BD1MXhsFShsrw%3D
    • Cappellini MD (2008) Long-term efficacy and safety of deferasirox. Blood Rev 22[Suppl 2]:S35-S41
    • (2008) Blood Rev , vol.22 , Issue.SUPPL. 2
    • Cappellini, M.D.1
  • 10
    • 52449130092 scopus 로고    scopus 로고
    • Acute interstitial nephritis due to deferasirox: A case report
    • 18653899 10.1093/ndt/gfn423
    • Brosnahan G, Gokden N, Swaminathan S (2008) Acute interstitial nephritis due to deferasirox: a case report. Nephrol Dial Transplant 23:3356-3358
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3356-3358
    • Brosnahan, G.1    Gokden, N.2    Swaminathan, S.3
  • 11
    • 77950492450 scopus 로고    scopus 로고
    • Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis
    • 20470310 10.1111/j.1440-1797.2009.01183.x
    • Yew CT, Talaulikar GS, Falk MC, Clayton P, D'Rozario J, Brown M (2010) Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis. Nephrology 15:377
    • (2010) Nephrology , vol.15 , pp. 377
    • Yew, C.T.1    Talaulikar, G.S.2    Falk, M.C.3    Clayton, P.4    D'Rozario, J.5    Brown, M.6
  • 12
    • 74549200866 scopus 로고    scopus 로고
    • Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major
    • 19934389 10.1345/aph.1M440
    • Papadopoulos N, Vasiliki A, Aloizos G, Tapinis P, Kikilas A (2010) Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major. Ann Pharmacother 44:219-221
    • (2010) Ann Pharmacother , vol.44 , pp. 219-221
    • Papadopoulos, N.1    Vasiliki, A.2    Aloizos, G.3    Tapinis, P.4    Kikilas, A.5
  • 14
    • 77954316682 scopus 로고    scopus 로고
    • Acute renal failure and Fanconi syndrome due to deferasirox
    • 20466673 10.1093/ndt/gfq224 1:CAS:528:DC%2BC3cXotFehtLg%3D
    • Grange S, Bertrand DM, Guerrot D, Eas F, Godin M (2010) Acute renal failure and Fanconi syndrome due to deferasirox. Nephrol Dial Transplant 25:2376-2378
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 2376-2378
    • Grange, S.1    Bertrand, D.M.2    Guerrot, D.3    Eas, F.4    Godin, M.5
  • 15
    • 75449084319 scopus 로고    scopus 로고
    • Deferasirox treatment may be associated with reversible renal Fanconi syndrome
    • 20052747
    • Even-Or E, Becker-Cohen R, Miskin H (2010) Deferasirox treatment may be associated with reversible renal Fanconi syndrome. Am J Hematol 85:132-134
    • (2010) Am J Hematol , vol.85 , pp. 132-134
    • Even-Or, E.1    Becker-Cohen, R.2    Miskin, H.3
  • 16
    • 77958173787 scopus 로고    scopus 로고
    • Acquired proximal renal tubular dysfunction in beta-thalassemia patients treated with deferasirox
    • 20733517 10.1097/MPH.0b013e3181ec0c38 1:CAS:528:DC%2BC3cXht1OisLfK
    • Yacobovich J, Stark P, Barzilai-Birenbaum S, Krause I, Pazgal I, Yaniv I, Tamary H (2010) Acquired proximal renal tubular dysfunction in beta-thalassemia patients treated with deferasirox. J Pediatr Hematol Oncol 32:564-567
    • (2010) J Pediatr Hematol Oncol , vol.32 , pp. 564-567
    • Yacobovich, J.1    Stark, P.2    Barzilai-Birenbaum, S.3    Krause, I.4    Pazgal, I.5    Yaniv, I.6    Tamary, H.7
  • 17
    • 79955671342 scopus 로고    scopus 로고
    • Fanconi syndrome in a patient with beta-thalassemia major after using deferasirox for 27 months
    • 21077910 10.1111/j.1537-2995.2010.02939.x
    • Wei HY, Yang CP, Cheng CH, Lo FS (2011) Fanconi syndrome in a patient with beta-thalassemia major after using deferasirox for 27 months. Transfusion 51:949-954
    • (2011) Transfusion , vol.51 , pp. 949-954
    • Wei, H.Y.1    Yang, C.P.2    Cheng, C.H.3    Lo, F.S.4
  • 18
    • 79551617114 scopus 로고    scopus 로고
    • Reversible Fanconi syndrome in a pediatric patient on deferasirox
    • 21298760 10.1002/pbc.22711
    • Rheault MN, Bechtel H, Neglia JP, Kashtan CE (2010) Reversible Fanconi syndrome in a pediatric patient on deferasirox. Pediatr Blood Cancer 56:674-676
    • (2010) Pediatr Blood Cancer , vol.56 , pp. 674-676
    • Rheault, M.N.1    Bechtel, H.2    Neglia, J.P.3    Kashtan, C.E.4
  • 19
    • 19444365814 scopus 로고    scopus 로고
    • Dangerous drugs for the kidney
    • 15904786 10.1016/j.arcped.2005.04.059 1:STN:280:DC%2BD2M3mt1Ojsw%3D%3D
    • Ghuysen MS (2005) Dangerous drugs for the kidney. Arch Pediatr 12:728-730
    • (2005) Arch Pediatr , vol.12 , pp. 728-730
    • Ghuysen, M.S.1
  • 20
    • 43449093775 scopus 로고    scopus 로고
    • Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders
    • 18413891 10.3324/haematol.12413
    • Angelucci E, Barosi G, Camaschella C, Cappellini MD, Cazzola M, Galanello R, Marchetti M, Piga A, Tura S (2008) Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica 93:741-752
    • (2008) Haematologica , vol.93 , pp. 741-752
    • Angelucci, E.1    Barosi, G.2    Camaschella, C.3    Cappellini, M.D.4    Cazzola, M.5    Galanello, R.6    Marchetti, M.7    Piga, A.8    Tura, S.9
  • 21
    • 0019052791 scopus 로고
    • Arterial blood pressure in 17,067 children and adolescents. Variation with age and height
    • 6969070 1:STN:280:DyaL3M%2FmtFKmsQ%3D%3D
    • Andre JL, Deschamps JP, Gueguen R (1980) Arterial blood pressure in 17,067 children and adolescents. Variation with age and height. Arch Fr Pediatr 37:477-482
    • (1980) Arch Fr Pediatr , vol.37 , pp. 477-482
    • Andre, J.L.1    Deschamps, J.P.2    Gueguen, R.3
  • 22
    • 77955582171 scopus 로고    scopus 로고
    • Adaptation of an enzymatic polyfructosan assay to clinical practice
    • 20541517 10.1016/j.ab.2010.06.016 1:CAS:528:DC%2BC3cXhtVaqu7jF
    • Dubourg L, Hadj-Aissa A, Ferrier B (2010) Adaptation of an enzymatic polyfructosan assay to clinical practice. Anal Biochem 405:266-268
    • (2010) Anal Biochem , vol.405 , pp. 266-268
    • Dubourg, L.1    Hadj-Aissa, A.2    Ferrier, B.3
  • 23
    • 0024720636 scopus 로고
    • A formula to estimate the approximate surface area if height and weight be known. 1916
    • 2520314
    • Du Bois D, Du Bois EF (1989) A formula to estimate the approximate surface area if height and weight be known. 1916. Nutrition 5:303-311
    • (1989) Nutrition , vol.5 , pp. 303-311
    • Du Bois, D.1    Du Bois, E.F.2
  • 26
    • 51649125405 scopus 로고    scopus 로고
    • Renal function in children with beta-thalassemia major and thalassemia intermedia
    • 18581145 10.1007/s00467-008-0897-8
    • Smolkin V, Halevy R, Levin C, Mines M, Sakran W, Ilia K, Koren A (2008) Renal function in children with beta-thalassemia major and thalassemia intermedia. Pediatr Nephrol 23:1847-1851
    • (2008) Pediatr Nephrol , vol.23 , pp. 1847-1851
    • Smolkin, V.1    Halevy, R.2    Levin, C.3    Mines, M.4    Sakran, W.5    Ilia, K.6    Koren, A.7
  • 28
    • 0037394673 scopus 로고    scopus 로고
    • Urine biochemical markers of early renal dysfunction are associated with iron overload in beta-thalassaemia
    • 12641614 10.1046/j.1365-2257.2003.00507.x 1:STN:280: DC%2BD3s7nslGiug%3D%3D
    • Koliakos G, Papachristou F, Koussi A, Perifanis V, Tsatra I, Souliou E, Athanasiou M (2003) Urine biochemical markers of early renal dysfunction are associated with iron overload in beta-thalassaemia. Clin Lab Haematol 25:105-109
    • (2003) Clin Lab Haematol , vol.25 , pp. 105-109
    • Koliakos, G.1    Papachristou, F.2    Koussi, A.3    Perifanis, V.4    Tsatra, I.5    Souliou, E.6    Athanasiou, M.7
  • 29
    • 77950530688 scopus 로고    scopus 로고
    • Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox
    • 20185899 10.1159/000287238 1:CAS:528:DC%2BC3cXktVyhsr0%3D
    • Economou M, Printza N, Teli A, Tzimouli V, Tsatra I, Papachristou F, Athanassiou-Metaxa M (2010) Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox. Acta Haematol 123:148-152
    • (2010) Acta Haematol , vol.123 , pp. 148-152
    • Economou, M.1    Printza, N.2    Teli, A.3    Tzimouli, V.4    Tsatra, I.5    Papachristou, F.6    Athanassiou-Metaxa, M.7
  • 32
    • 18144368022 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation Exjade (deferasirox)
    • Novartis Pharmaceuticals Corporation (2009) Exjade (deferasirox). Prescribing information. Available at: http://www.pharma.us.novartis.com/ product/pi/pdf/exjade
    • (2009) Prescribing Information
  • 33
    • 0028085704 scopus 로고
    • Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy
    • 7967359 10.1038/ki.1994.295 1:STN:280:DyaK2M%2Fls1ymtw%3D%3D
    • Cianciulli P, Sollecito D, Sorrentino F, Forte L, Gilardi E, Massa A, Papa G, Carta S (1994) Early detection of nephrotoxic effects in thalassemic patients receiving desferrioxamine therapy. Kidney Int 46:467-470
    • (1994) Kidney Int , vol.46 , pp. 467-470
    • Cianciulli, P.1    Sollecito, D.2    Sorrentino, F.3    Forte, L.4    Gilardi, E.5    Massa, A.6    Papa, G.7    Carta, S.8
  • 35
    • 0038324389 scopus 로고    scopus 로고
    • Development of tridentate iron chelators: From desferrithiocin to ICL670
    • 12678677 10.2174/0929867033457610 1:CAS:528:DC%2BD3sXjs1yjtbo%3D
    • Nick H, Acklin P, Lattmann R, Buehlmayer P, Hauffe S, Schupp J, Alberti D (2003) Development of tridentate iron chelators: from desferrithiocin to ICL670. Curr Med Chem 10:1065-1076
    • (2003) Curr Med Chem , vol.10 , pp. 1065-1076
    • Nick, H.1    Acklin, P.2    Lattmann, R.3    Buehlmayer, P.4    Hauffe, S.5    Schupp, J.6    Alberti, D.7
  • 38
    • 70450133176 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox (Exjade®) with up to 4.5 years of treatment in patients with thalassemia major: A pooled analysis (abstract)
    • Cappellini MD, Galanello R, Piga A, Cohen A, Kattamis A, Aydinok Y, Williamson P, Rojkjaer L, Porter JB (2008) Efficacy and safety of deferasirox (Exjade®) with up to 4.5 years of treatment in patients with thalassemia major: a pooled analysis (abstract). Blood 112:5411
    • (2008) Blood , vol.112 , pp. 5411
    • Cappellini, M.D.1    Galanello, R.2    Piga, A.3    Cohen, A.4    Kattamis, A.5    Aydinok, Y.6    Williamson, P.7    Rojkjaer, L.8    Porter, J.B.9
  • 39
    • 70450127262 scopus 로고    scopus 로고
    • Deferasirox (Exjade®) in pediatric patients with β-thalassemia: Update of 4.7-year efficacy and safety from extension studies (abstract)
    • Piga A, Forni GL, Kattamis A, Kattamis C, Aydinok Y, Rodriguez M, Rojkjaer L, Galanello R (2008) Deferasirox (Exjade®) in pediatric patients with β-thalassemia: update of 4.7-year efficacy and safety from extension studies (abstract). Blood 112:3883
    • (2008) Blood , vol.112 , pp. 3883
    • Piga, A.1    Forni, G.L.2    Kattamis, A.3    Kattamis, C.4    Aydinok, Y.5    Rodriguez, M.6    Rojkjaer, L.7    Galanello, R.8
  • 41
    • 53549119994 scopus 로고    scopus 로고
    • Desferrithiocin analogues and nephrotoxicity
    • 18788724 10.1021/jm8003398 1:CAS:528:DC%2BD1cXhtFelt7%2FI
    • Bergeron RJ, Wiegand J, McManis JS, Bharti N, Singh S (2008) Desferrithiocin analogues and nephrotoxicity. J Med Chem 51:5993-6004
    • (2008) J Med Chem , vol.51 , pp. 5993-6004
    • Bergeron, R.J.1    Wiegand, J.2    McManis, J.S.3    Bharti, N.4    Singh, S.5
  • 42
    • 77958161115 scopus 로고    scopus 로고
    • Renal Fanconi syndrome secondary to deferasirox: Where there is smoke there is fire
    • 20686423 10.1097/MPH.0b013e3181ec0c4d
    • Baum M (2010) Renal Fanconi syndrome secondary to deferasirox: where there is smoke there is fire. J Pediatr Hematol Oncol 32:525-526
    • (2010) J Pediatr Hematol Oncol , vol.32 , pp. 525-526
    • Baum, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.