메뉴 건너뛰기




Volumn 46, Issue 1, 2012, Pages 217-220

Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice

Author keywords

Ageing; Alzheimer's disease; Hypoxia inducible factor; Iron chelator; Multi functional drug; Neuroprotection; amyloid plaques

Indexed keywords

5 (N METHYL N PROPARGYLAMINOMETHYL) 8 HYDROXYQUINOLINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; HYPOXIA INDUCIBLE FACTOR; IRON CHELATING AGENT; UNCLASSIFIED DRUG;

EID: 84868093104     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8304-7     Document Type: Article
Times cited : (37)

References (21)
  • 1
    • 77954947811 scopus 로고    scopus 로고
    • Neuroprotective multifunctional iron chelators: From redox-sensitive process to novel therapeutic opportunities
    • Weinreb O, Amit T, Mandel S, Kupershmidt L, Youdim MB (2010) Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities. Antioxid Redox Signal 13(6):919-949
    • (2010) Antioxid Redox Signal , vol.13 , Issue.6 , pp. 919-949
    • Weinreb, O.1    Amit, T.2    Mandel, S.3    Kupershmidt, L.4    Youdim, M.B.5
  • 3
    • 63449129338 scopus 로고    scopus 로고
    • Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress: The role of a putative iron-responsive element
    • Olivares D, Huang X, Branden L, Greig NH, Rogers JT (2009) Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress: the role of a putative iron-responsive element. Int J Mol Sci 10(3):1226-1260
    • (2009) Int J Mol Sci , vol.10 , Issue.3 , pp. 1226-1260
    • Olivares, D.1    Huang, X.2    Branden, L.3    Greig, N.H.4    Rogers, J.T.5
  • 4
    • 84655164280 scopus 로고    scopus 로고
    • The role of metallobiology and amyloid-β peptides in Alzheimer's disease
    • Roberts BR, Ryan TM, Bush AI, Masters CL, Duce JA (2012) The role of metallobiology and amyloid-β peptides in Alzheimer's disease. J Neurochem 120(Suppl 1):149-166
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 149-166
    • Roberts, B.R.1    Ryan, T.M.2    Bush, A.I.3    Masters, C.L.4    Duce, J.A.5
  • 6
    • 11844255676 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases
    • DOI 10.1016/j.bmc.2004.10.037, PII S0968089604008399
    • Zheng H, Weiner LM, Bar-Am O, Epsztejn S, Cabantchik ZI, Warshawsky A, Youdim MB, Fridkin M (2005) Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases. Bioorg Med Chem 13(3):773-783 (Pubitemid 40093620)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.3 , pp. 773-783
    • Zheng, H.1    Weiner, L.M.2    Bar-Am, O.3    Epsztejn, S.4    Cabantchik, Z.I.5    Warshawsky, A.6    Youdim, M.B.H.7    Fridkin, M.8
  • 7
    • 84860290271 scopus 로고    scopus 로고
    • From antioxidant chelators to site-activated multi-target chelators targeting hypoxia inducing factor, beta-amyloid, acetylcholinesterase and monoamine oxidase A/B
    • Zheng H, Fridkin M, Youdim MB (2012) From antioxidant chelators to site-activated multi-target chelators targeting hypoxia inducing factor, beta-amyloid, acetylcholinesterase and monoamine oxidase A/B. Mini Rev Med Chem 12(5):364-370
    • (2012) Mini Rev Med Chem , vol.12 , Issue.5 , pp. 364-370
    • Zheng, H.1    Fridkin, M.2    Youdim, M.B.3
  • 8
    • 0346849912 scopus 로고    scopus 로고
    • Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
    • DOI 10.1016/j.neuropharm.2003.09.005
    • Shachar DB, Kahana N, Kampel V, Warshawsky A, Youdim MB (2004) Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats. Neuropharmacology 46 (2):254-263 (Pubitemid 37532833)
    • (2004) Neuropharmacology , vol.46 , Issue.2 , pp. 254-263
    • Shachar, D.B.1    Kahana, N.2    Kampel, V.3    Warshawsky, A.4    Youdim, M.B.H.5
  • 9
    • 25644452043 scopus 로고    scopus 로고
    • Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion
    • DOI 10.1111/j.1471-4159.2005.03341.x
    • Gal S, Zheng H, Fridkin M, Youdim MBH (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTPinduced striatal dopamine depletion. J Neurochem 95(1):79-88 (Pubitemid 41384427)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.1 , pp. 79-88
    • Gal, S.1    Zheng, H.2    Fridkin, M.3    Youdim, M.B.H.4
  • 10
    • 77956688613 scopus 로고    scopus 로고
    • Limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30
    • Gal S, Abassi ZA, Youdim MB (2010) Limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30. Neurotox Res 18(2):143-150
    • (2010) Neurotox Res , vol.18 , Issue.2 , pp. 143-150
    • Gal, S.1    Abassi, Z.A.2    Youdim, M.B.3
  • 11
    • 77449119388 scopus 로고    scopus 로고
    • Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30
    • Gal S, Zheng H, Fridkin M, Youdim MB (2010) Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30. Neurotox Res 17(1):15-27
    • (2010) Neurotox Res , vol.17 , Issue.1 , pp. 15-27
    • Gal, S.1    Zheng, H.2    Fridkin, M.3    Youdim, M.B.4
  • 12
    • 36849044036 scopus 로고    scopus 로고
    • Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators
    • DOI 10.1096/fj.07-8386com
    • ZhuW, XieW, Pan T,Xu P, FridkinM, ZhengH, Jankovic J,Youdim MB, Le W (2007) Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brainpermeable iron chelators. FASEBJ 21(14):3835-3844 (Pubitemid 350232341)
    • (2007) FASEB Journal , vol.21 , Issue.14 , pp. 3835-3844
    • Zhu, W.1    Xie, W.2    Pan, T.3    Xu, P.4    Fridkin, M.5    Zheng, H.6    Jankovic, J.7    Youdim, M.B.H.8    Le, W.9
  • 13
    • 70350521966 scopus 로고    scopus 로고
    • Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis
    • Kupershmidt L, Weinreb O, Amit T, Mandel S, Carri MT, Youdim MB (2009) Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 23(11):3766-3779
    • (2009) FASEB J , vol.23 , Issue.11 , pp. 3766-3779
    • Kupershmidt, L.1    Weinreb, O.2    Amit, T.3    Mandel, S.4    Carri, M.T.5    Youdim, M.B.6
  • 14
    • 75149138761 scopus 로고    scopus 로고
    • Prolyl hydroxylases and therapeutics
    • Smith TG, Talbot NP (2010) Prolyl hydroxylases and therapeutics. Antioxid Redox Signal 12(4):431-439
    • (2010) Antioxid Redox Signal , vol.12 , Issue.4 , pp. 431-439
    • Smith, T.G.1    Talbot, N.P.2
  • 16
    • 75149124682 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain inhibitors: A route to HIF activation and neuroprotection
    • Harten SK, Ashcroft M, Maxwell PH (2010) Prolyl hydroxylase domain inhibitors: A route to HIF activation and neuroprotection. Antioxid Redox Signal 12(4):459-480
    • (2010) Antioxid Redox Signal , vol.12 , Issue.4 , pp. 459-480
    • Harten, S.K.1    Ashcroft, M.2    Maxwell, P.H.3
  • 17
    • 57649148810 scopus 로고    scopus 로고
    • Mitochondria and hypoxia-induced gene expression mediated by hypoxia-inducible factors
    • Chavez A, Miranda LF, Pichiule P, Chavez JC (2008) Mitochondria and hypoxia-induced gene expression mediated by hypoxia-inducible factors. Ann N Y Acad Sci 1147:312-320
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 312-320
    • Chavez, A.1    Miranda, L.F.2    Pichiule, P.3    Chavez, J.C.4
  • 18
    • 77953826537 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor (HIF)-1a and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30
    • Avramovich-Tirosh Y, Bar-Am O, Amit T, Youdim MBH Weinreb O (2010). Up-regulation of hypoxia-inducible factor (HIF)-1a and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30. Curr Alzheimer Res 7(4): 300-306
    • (2010) Curr Alzheimer Res , vol.7 , Issue.4 , pp. 300-306
    • Avramovich-Tirosh, Y.1    Bar-Am, O.2    Amit, T.3    Youdim, M.B.H.4    Weinreb, O.5
  • 19
    • 79960895695 scopus 로고    scopus 로고
    • Novel molecular targets of the neuroprotective/ neurorescue multimodal iron chelating drug M30 in the mouse brain
    • Kupershmidt L, Weinreb O, Amit T, Mandel S, Bar-Am O, Youdim MB (2011) Novel molecular targets of the neuroprotective/ neurorescue multimodal iron chelating drug M30 in the mouse brain. Neuroscience 189:345-358
    • (2011) Neuroscience , vol.189 , pp. 345-358
    • Kupershmidt, L.1    Weinreb, O.2    Amit, T.3    Mandel, S.4    Bar-Am, O.5    Youdim, M.B.6
  • 20
    • 84861235044 scopus 로고    scopus 로고
    • Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice
    • Kupershmidt L, Amit T, Bar-Am O, Youdim MB, Weinreb O (2012) Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice. Mech Ageing Dev 133(5):267-274
    • (2012) Mech Ageing Dev , vol.133 , Issue.5 , pp. 267-274
    • Kupershmidt, L.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4    Weinreb, O.5
  • 21
    • 84863896457 scopus 로고    scopus 로고
    • The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease
    • Kupershmidt L, Amit T, Bar Am O, Youdim MB, Weinreb O (2012) The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease. Antioxid Redox Signal 17 (6):860-877
    • (2012) Antioxid Redox Signal , vol.17 , Issue.6 , pp. 860-877
    • Kupershmidt, L.1    Amit, T.2    Bar Am, O.3    Youdim, M.B.4    Weinreb, O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.