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Volumn 28, Issue 6, 2012, Pages 2035-2042

PELP1/MNAR suppression inhibits proliferation and metastasis of endometrial carcinoma cells

Author keywords

Co activator; Endometrial carcinoma; Glutamic acid and leucine rich protein 1 modulator of non genomic activity of estrogen receptor; Metastasis; Proline

Indexed keywords

CELL NUCLEUS RECEPTOR; GELATINASE A; GELATINASE B; MODULATOR OF NON GENOMIC ACTIVITY OF ESTROGEN RECEPTOR; PROLINE GLUTAMIC ACID LEUCINE RICH PROTEIN 1; UNCLASSIFIED DRUG;

EID: 84868090299     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2038     Document Type: Conference Paper
Times cited : (13)

References (35)
  • 1
    • 41149100205 scopus 로고    scopus 로고
    • Gynecologic malignancies
    • DOI 10.1016/j.suc.2008.01.004, PII S0039610908000054
    • Whitcomb BP: Gynecologic malignancies. Surg Clin North Am 88:301-317, vi, 2008. (Pubitemid 351434424)
    • (2008) Surgical Clinics of North America , vol.88 , Issue.2 , pp. 301-317
    • Whitcomb, B.P.1
  • 2
    • 84868121062 scopus 로고    scopus 로고
    • Endocrine-related cancer
    • Schwab M ed. 2nd edition. Springer-Verlag, Heidelberg
    • Zhang H: Endocrine-related cancer. In: Encyclopedia of Cancer. Schwab M (ed). 2nd edition. Springer-Verlag, Heidelberg, pp435-439, 2008.
    • (2008) Encyclopedia of Cancer , pp. 435-439
    • Zhang, H.1
  • 3
    • 33646371740 scopus 로고    scopus 로고
    • Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
    • Shang Y: Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer 6:360-368, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 360-368
    • Shang, Y.1
  • 4
    • 26444467147 scopus 로고    scopus 로고
    • Estrogen receptors and cell signaling
    • Pietras RJ, Levin ER and Szego CM: Estrogen receptors and cell signaling. Science 310:51-53, 2005.
    • (2005) Science , vol.310 , pp. 51-53
    • Pietras, R.J.1    Levin, E.R.2    Szego, C.M.3
  • 5
    • 1042292612 scopus 로고    scopus 로고
    • Advances in estrogen receptor biology: Prospects for improvements in targeted breast cancer therapy
    • DOI 10.1186/bcr742
    • Shao W and Brown M: Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res 6:39-52, 2004. (Pubitemid 38195559)
    • (2004) Breast Cancer Research , vol.6 , Issue.1 , pp. 39-52
    • Shao, W.1    Brown, M.2
  • 6
    • 3543119043 scopus 로고    scopus 로고
    • Genomic targets of nuclear estrogen receptors
    • DOI 10.1210/me.2003-0044
    • O'Lone R, Frith MC, Karlsson EK and Hansen U: Genomic targets of nuclear estrogen receptors. Mol Endocrinol 18:1859-1875, 2004. (Pubitemid 39022608)
    • (2004) Molecular Endocrinology , vol.18 , Issue.8 , pp. 1859-1875
    • O'Lone, R.1    Frith, M.C.2    Karlsson, E.K.3    Hansen, U.4
  • 7
    • 15444368857 scopus 로고    scopus 로고
    • Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target genes
    • DOI 10.1210/me.2004-0486
    • Bjornstrom L and Sjoberg M: Mechanisms of estrogen receptor signaling: convergence of genomic and non-genomic actions on target genes. Mol Endocrinol 19:833-842, 2005. (Pubitemid 40397050)
    • (2005) Molecular Endocrinology , vol.19 , Issue.4 , pp. 833-842
    • Bjornstrom, L.1    Sjoberg, M.2
  • 8
    • 25144517216 scopus 로고    scopus 로고
    • Estrogen rapid action via protein complex formation involving ERα and Src
    • DOI 10.1016/j.tem.2005.06.010, PII S1043276005001840
    • Song RX, Zhang Z and Santen RJ: Estrogen rapid action via protein complex formation involving ERalpha and Src. Trends Endocrinol Metab 16:347-353, 2005. (Pubitemid 41338739)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.8 , pp. 347-353
    • Song, R.X.-D.1    Zhang, Z.2    Santen, R.J.3
  • 9
    • 0037224484 scopus 로고    scopus 로고
    • Non-genomic actions of steroid hormones
    • Losel R and Wehling M: Non-genomic actions of steroid hormones. Nat Rev Mol Cell Biol 4:46-56, 2004.
    • (2004) Nat Rev Mol Cell Biol , vol.4 , pp. 46-56
    • Losel, R.1    Wehling, M.2
  • 10
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: Cellular and molecular biology
    • Mckenna NJ, Lanz RB and O'Malley BW: Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321-344, 1999. (Pubitemid 30649811)
    • (1999) Endocrine Reviews , vol.20 , Issue.3 , pp. 321-344
    • McKenna, N.J.1    Lanz, R.B.2    O'Malley, B.W.3
  • 11
    • 30344479480 scopus 로고    scopus 로고
    • Coregulators in nuclear estrogen receptor action: From concept to therapeutic targeting
    • DOI 10.1124/mi.5.6.7
    • Hall JM and Mcdonnell DP: Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv 5:343-357, 2005. (Pubitemid 43060715)
    • (2005) Molecular Interventions , vol.5 , Issue.6 , pp. 343-357
    • Hall, J.M.1    McDonnell, D.P.2
  • 12
    • 1242351785 scopus 로고    scopus 로고
    • Novel estrogen receptor coregulators and signaling molecules in human diseases
    • DOI 10.1007/s00018-003-3222-5
    • Barnes CJ, Vadlamudi RK and Kumar R: Novel estrogen receptor coregulators and signaling molecules in human diseases. Cell Mol Life Sci 61:281-291, 2004. (Pubitemid 38223405)
    • (2004) Cellular and Molecular Life Sciences , vol.61 , Issue.3 , pp. 281-291
    • Barnes, C.J.1    Vadlamudi, R.K.2    Kumar, R.3
  • 13
    • 29444449329 scopus 로고    scopus 로고
    • Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
    • DOI 10.1210/me.2005-0310
    • Han SJ, Demayo FJ, Xu J, Tsai SY, Tsai MJ and O'Malley BW: Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol 20:45-55, 2006. (Pubitemid 43011669)
    • (2006) Molecular Endocrinology , vol.20 , Issue.1 , pp. 45-55
    • Han, S.J.1    DeMayo, F.J.2    Xu, J.3    Tsai, S.Y.4    Tsai, M.-J.5    O'Malley, B.W.6
  • 14
    • 34250881447 scopus 로고    scopus 로고
    • Coregulators: From whence came these "master genes"
    • DOI 10.1210/me.2007-0012
    • O'Malley BW: Coregulators: from whence came these master genes'. Mol Endocrinol 21:1009-1013, 2007. (Pubitemid 46984754)
    • (2007) Molecular Endocrinology , vol.21 , Issue.5 , pp. 1009-1013
    • O'Malley, B.W.1
  • 15
    • 34249991443 scopus 로고    scopus 로고
    • Clinical implications of steroid receptor coactivator (SRC)-3 in uterine endometrial cancers
    • DOI 10.1016/j.jsbmb.2007.03.007, PII S0960076007000635, 17th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology 'Recent Advances in Steroid Biochemistry and Molecular Biology'
    • Sakaguchi H, Fujimto J and Sun WS: Clinical implications of steroid receptor coactivator (SRC)-3 in uterine endometrial cancers. J Steroid Biochem Mol Biol 104:237-240, 2007. (Pubitemid 46891818)
    • (2007) Journal of Steroid Biochemistry and Molecular Biology , vol.104 , Issue.3-5 , pp. 237-240
    • Sakaguchi, H.1    Fujimoto, J.2    Sun, W.-S.3    Tamaya, T.4
  • 16
    • 34547731515 scopus 로고    scopus 로고
    • Nuclear receptor coregulators and human disease
    • DOI 10.1210/er.2007-0012
    • Lanard DM, Lanz RB and O'Malhy BW: Nuclear receptor coregulators and human disease. Endocr Rev 28:575-587, 2007. (Pubitemid 47236337)
    • (2007) Endocrine Reviews , vol.28 , Issue.5 , pp. 575-587
    • Lonard, D.M.1    Lanz, R.B.2    O'Malley, B.W.3
  • 17
    • 33646238716 scopus 로고    scopus 로고
    • MTA1, a transcriptional activator of breast cancer amplified sequence 3
    • Gururaj AE, Singh RR and Rayala SK: MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci USA 103:6670-6675, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6670-6675
    • Gururaj, A.E.1    Singh, R.R.2    Rayala, S.K.3
  • 18
    • 2442635964 scopus 로고    scopus 로고
    • ER beta binds N-CoR in the presence of estrogens via an LXXLL-like motif in the N-CoR C-terminus
    • Webb P, Valentine C and Nguyen P: ER beta binds N-CoR in the presence of estrogens via an LXXLL-like motif in the N-CoR C-terminus. Nucl Recept 1:4, 2003.
    • (2003) Nucl Recept , vol.1 , pp. 4
    • Webb, P.1    Valentine, C.2    Nguyen, P.3
  • 19
    • 1842850816 scopus 로고    scopus 로고
    • Cloning and functional characterization of PELP1/MNAR promoter
    • DOI 10.1016/j.gene.2004.01.011, PII S037811190400037X
    • Mishra SK, Balasenthil S and Ngnyen D: Cloning and functional characterization of PELP1/MNAR promoter. Gene 330:115-122, 2004. (Pubitemid 38490424)
    • (2004) Gene , vol.330 , Issue.1-2 , pp. 115-122
    • Mishra, S.K.1    Balasenthil, S.2    Nguyen, D.3    Vadlamudi, R.K.4
  • 20
    • 77953121401 scopus 로고    scopus 로고
    • PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity
    • Nair SS, Nair BC, Cortez V, Chakravarty D, Metzger E, Schüle R, Brann DW, Tekmal RR and Vadlamudi RK: PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO Rep 11:438-444, 2010.
    • (2010) EMBO Rep , vol.11 , pp. 438-444
    • Nair, S.S.1    Nair, B.C.2    Cortez, V.3    Chakravarty, D.4    Metzger, E.5    Schüle, R.6    Brann, D.W.7    Tekmal, R.R.8    Vadlamudi, R.K.9
  • 21
    • 44549086936 scopus 로고    scopus 로고
    • MNAR plays an important role in ERα activation of Src/MAPK and PI3K/Akt signaling pathways
    • Cheskis B J, Greger J, Cooch N, et al: MNAR plays an important role in ERα activation of Src/MAPK and PI3K/Akt signaling pathways. Steroids 73:901-905, 2008.
    • (2008) Steroids , vol.73 , pp. 901-905
    • Cheskis, B.J.1    Greger, J.2    Cooch, N.3
  • 22
    • 33750061041 scopus 로고    scopus 로고
    • Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR
    • DOI 10.1007/s10585-006-9019-9
    • Rajhans R and Vadlamudi RK: Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR. Clin Exp Metastasis 23:1-7, 2006. (Pubitemid 44576774)
    • (2006) Clinical and Experimental Metastasis , vol.23 , Issue.1 , pp. 1-7
    • Rajhans, R.1    Vadlamudi, R.K.2
  • 23
    • 34250619620 scopus 로고    scopus 로고
    • Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
    • Vadlamudi RK and Kumar R: Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR. Nucl Recept Signal 5:e004, 2007.
    • (2007) Nucl Recept Signal , vol.5
    • Vadlamudi, R.K.1    Kumar, R.2
  • 24
    • 33847194532 scopus 로고    scopus 로고
    • PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2
    • Nair SS, Guo Z, Mueller J M, et al: PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2. Mol Endocrinol 21:613-624, 2007.
    • (2007) Mol Endocrinol , vol.21 , pp. 613-624
    • Nair, S.S.1    Guo, Z.2    Mueller, J.M.3
  • 25
    • 34347208713 scopus 로고    scopus 로고
    • Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor
    • DOI 10.1158/0008-5472.CAN-06-3647
    • Rajhans R, Nair S, Holden AH, Kumar R, Tekmal RR and Vadlamudi RK: Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor. Cancer Res 67:5505-5512, 2007. (Pubitemid 46997292)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5505-5512
    • Rajhans, R.1    Nair, S.2    Holden, A.H.3    Kumar, R.4    Tekmal, R.R.5    Vadlamudi, R.K.6
  • 26
    • 77950858916 scopus 로고    scopus 로고
    • The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype
    • Habashy HO, Powe DG, Rakha EA, et al: The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype. Breast Cancer Res Treat 120:603-612, 2010.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 603-612
    • Habashy, H.O.1    Powe, D.G.2    Rakha, E.A.3
  • 27
    • 10344251495 scopus 로고    scopus 로고
    • Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors
    • DOI 10.1210/jc.2004-0909
    • Vadlamudi RK, Balasenthil S, Broaddus RR, Gustafsson JA and Kumar R: Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. Clin Endocrinol Metab 89:6130-6138, 2004. (Pubitemid 39628425)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6130-6138
    • Vadlamudi, R.K.1    Balasenthil, S.2    Broaddus, R.R.3    Gustafsson, J.-A.4    Kumar, R.5
  • 28
    • 49649094092 scopus 로고    scopus 로고
    • Role of PELP1/MNAR signaling in ovarian tumorigenesis
    • Dimple C, Nair SS, Rajhans R, et al: Role of PELP1/MNAR signaling in ovarian tumorigenesis. Cancer Res 68:4902-4909, 2008.
    • (2008) Cancer Res , vol.68 , pp. 4902-4909
    • Dimple, C.1    Nair, S.S.2    Rajhans, R.3
  • 29
    • 70350537033 scopus 로고    scopus 로고
    • Nuclear receptor coregulators in cancer biology
    • O'Malley BW and Kumar R: Nuclear receptor coregulators in cancer biology. Cancer Res 69:8217-8222, 2009.
    • (2009) Cancer Res , vol.69 , pp. 8217-8222
    • O'Malley, B.W.1    Kumar, R.2
  • 30
    • 77951129233 scopus 로고    scopus 로고
    • PELP1: A novel therapeutic target for hormonal cancers
    • Chakravarty D, Tekmal RR and Vadlamudi RK: PELP1: a novel therapeutic target for hormonal cancers. IUBMB Life 62:163-169, 2010.
    • (2010) IUBMB Life , vol.62 , pp. 163-169
    • Chakravarty, D.1    Tekmal, R.R.2    Vadlamudi, R.K.3
  • 32
    • 0037483087 scopus 로고    scopus 로고
    • Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein
    • DOI 10.1074/jbc.M212822200
    • Balasenthil S and Vadlamudi RK: Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. J Biol Chem 278:22119-22127, 2003. (Pubitemid 36792622)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.24 , pp. 22119-22127
    • Balasenthil, S.1    Vadlamudi, R.K.2
  • 33
    • 77956914563 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1
    • Nair BC, Nair SS, Chakravarty D, et al: Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1. Cancer Res 70:7166-7175, 2010.
    • (2010) Cancer Res , vol.70 , pp. 7166-7175
    • Nair, B.C.1    Nair, S.S.2    Chakravarty, D.3
  • 35
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174, 2002. (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2


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