Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function

Gastroenterology

Volumn 143, Issue 5, 2012, Pages 1308-1318

  Singh, Jagmohan ^a   Cohen, Sidney ^a   Mehendiratta, Vaibhav ^a   Mendoza, Fabian ^a   Jimenez, Sergio A ^a   Dimarino, Anthony J ^a   Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Animal Model; Connective Tissue Disease; Fibrosis; Smooth Muscle Atrophy; Systemic sclerosis (scleroderma)

Indexed keywords

EID: 84868036007     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.07.109     Document Type: Article

References (33)

1. A. Gabrielli, E.V. Avvedimento, T. Krieg Mechanisms of disease: scleroderma N Engl J Med 360 2009 1989 2003
2. S. Cohen The gastrointestinal manifestations of scleroderma: pathogenesis and management Gastroenterology 79 1980 155 166
3. A.J. DiMarino, G. Carlson, A. Myers Duodenal myoelectric activity in scleroderma Abnormal responses to mechanical and hormonal stimuli N Engl J Med 289 1973 1220 1223
4. D. Alper, E. Ram, G.Y. Stein Resting anal pressure following hemorrhoidectomy and lateral sphincterotomy Dis Colon Rectum 48 2005 2080 2084
5. M. Trezza, K. Krogh, H. Egekvist Bowel problems in patients with systemic sclerosis Scand J Gastroenterol 34 1999 409 413
6. C.E. Koh, C.J. Young, C.M. Wright The internal anal sphincter in systemic sclerosis Dis Colon Rectum 52 2009 315 318
7. A.F. Engel, M.A. Kamm, I.C. Talbot Progressive systemic sclerosis of the internal anal sphincter leading to passive faecal incontinence Gut 35 1994 857 859
8. 3 muscarinic receptors in primary Sjögren's syndrome Clin Exp Immunol 104 1996 454 459
9. F. Goldblatt, T.P. Gordon, S.A. Waterman Antibody-mediated gastrointestinal dysmotility in scleroderma Gastroenterology 123 2002 1144 1150
10. J. Singh, V. Mehendiratta, F. Del Galdo Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells Am J Physiol Gastrointest Liver Physiol 297 2009 G1206 G1213
11. M. Baleva, K. Nikolov The role of intravenous immunoglobulin preparations in the treatment of systemic sclerosis Int J Rheumatol 2011 2011 1 4
12. M. Ballow The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders J Allergy Clin Immunol 127 2011 315 323
13. J. Bayry, M. Thirion, N. Misra Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases Neurol Sci 4 2003 S217 S221
14. T. McGaha, S. Saito, R.G. Phelps Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4Rα and transforming factor-β genes J Invest Dermatol 116 2001 136 143
15. M. Blank, Y. Levy, H. Amital The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice Arthritis Rheum 46 2002 1689 1690
16. G.D. Sempowski, M.P. Beckman, S.D. Derdak Subsets of murine lung fibroblasts express membrane-bound and soluble IL- 4 receptors: role of IL-4 in enhancing fibroblast proliferation and collagen synthesis J Immunol 152 1994 3606 3614
17. E.C. LeRoy, C. Black, R. Fleischmajer Scleroderma (systemic sclerosis): classification, subsets and pathogenesis J Rheumatol 15 2009 202 205
18. A. Ouyang, G.R. Locke III Overview of neurogastroenterology- gastrointestinal motility and functional GI disorders: classification, prevalence, and epidemiology Gastroenterol Clin North Am 36 2007 485 498
19. A.C. Grodzki, E. Berenstein Antibody purification: affinity chromatography-protein A and protein G Sepharose Methods Mol Biol 588 2010 33 41
20. J. Singh, P.J. Maxwell IV, S. Rattan Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells Am J Physiol Gastrointest Liver Physiol 301 2011 G317 G325
21. E.M.M. Manders, F.J. Verbeek, J.A. Aten Measurement of co-localization of objects in dual-colour confocal images J Microsc 169 1993 375 382
22. C.A. Patel, S. Rattan Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK Am J Physiol Gastrointest Liver Physiol 292 2007 G1747 G1756
23. N.Y. Koo, J. Li, S.M. Hwang Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjogren's syndrome patients Rheumatology 47 2008 828 833
24. S. Chakder, K.M. McHugh, S. Rattan Inhibitory neurotransmission in lethal spotted mutant mice: a model for Hirschsprung's disease Gastroenterology 112 1997 1575 1585
25. S. Rattan, M.A.F. De Godoy, C.A. Patel Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter Gastroenterology 131 2006 108 116
26. P. Biancani, J.H. Walsh, J. Behar Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter Gastroenterology 89 1985 867 874
27. 3 muscarinic acetylcholine receptor activation J Biol Chem 282 2007 7385 7396
28. D. Cavill, S.A. Waterman, T.P. Gordon Antiidiotypic antibodies neutralize autoantibodies that inhibit cholinergic neurotransmission Arthritis Rheum 48 2003 4597 4602
29. A.J. Smith, M.W. Jackson, F. Wang Neutralization of muscarinic receptor autoantibodies by intravenous immunoglobulin in Sjögren syndrome Hum Immunol 66 2005 411 416
30. L. Dawson, A. Tobin, P. Smith Antimuscarinic antibodies in Sjögren's syndrome: where are we, and where are we going? Arthritis Rheum 52 2005 2984 2995
31. M. Schmidt, M. Frings, M.L. Mono Protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases J Biochem 275 2000 32603 32610
32. C.J. Van Koppen Multiple pathways for the dynamin-regulated internalization of muscarinic acetylcholine receptors Biochem Soc Trans 29 2001 505 508
33. V. Siragam, A.R. Crow, D. Brinc Intravenous immunoglobulin ameliorates ITP via activating Fcγ receptors on dendritic cells Nat Med 12 2006 688 692