Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 297, Issue 6, 2009, Pages

  Singh, Jagmohan ^a   Mehendiratta, Vaibhav ^a   Del Galdo, Francesco ^a   Jimenez, Sergio A ^a   Cohen, Sidney ^b   DiMarino, Anthony J ^a   Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NONE

Author keywords

Autoantibodies; Muscarinic receptor; Rectoanal function; Systemic sclerosis

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BETHANECHOL; CARBACHOL; IMMUNOGLOBULIN G; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; NEUTRALIZING ANTIBODY; PHENYLEPHRINE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANUS SPHINCTER; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL SIZE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN CELL; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SCLERODERMA; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYSTEMIC SCLEROSIS; WESTERN BLOTTING;

ADRENERGIC ALPHA-AGONISTS; ADULT; AGED; AGED, 80 AND OVER; ANAL CANAL; ANIMALS; AUTOANTIBODIES; BENZOFURANS; BETHANECHOL; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOGLOBULINS; MALE; MIDDLE AGED; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MYOCYTES, SMOOTH MUSCLE; PHENYLEPHRINE; PIPERIDINES; POTASSIUM CHLORIDE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M3; SCLERODERMA, SYSTEMIC;

EID: 72749089603     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00286.2009     Document Type: Article

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