HY251, a novel decahydrocyclopenta[a]indene analog, induces apoptosis via tBid-mediated intrinsic pathway in human ovarian cancer PA-1 cells

Journal of Microbiology and Biotechnology

Volumn 22, Issue 11, 2012, Pages 1591-1595

  Suh, Hyewon ^a   Choi, Ko woon ^a   Kim, Myung Sic ^a   Kim, Jeong Hyeon ^a   Noh, Sun Young ^a   Sung, Moon Hee ^b   Lee, Chul Hoon ^a  

^a Hanyang University   (South Korea)

^b Kookmin University   (South Korea)

Author keywords

Apoptotic induction; Aralia continentalis; Cytochrome c; PA 1 cells; tBid

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; HY 251; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NICK END LABELING; OVARY CANCER; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; FEMALE; HUMANS; INDENES; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; VINYL COMPOUNDS;

ARALIA CONTINENTALIS;

EID: 84868030520     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1209.09022     Document Type: Article

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