Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells

Journal of Cellular Physiology

Volumn 228, Issue 2, 2013, Pages 341-348

  Chuang, Chun Wei ^a   Pan, Mei Ren ^b   Hou, Ming Feng ^c   Hung, Wen Chun ^b,c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CHEMOKINE RECEPTOR CCR7; CYCLOOXYGENASE 2; PROSTAGLANDIN E2; PROTEIN KINASE B; SERINE; SHORT HAIRPIN RNA; THREONINE; TRANSCRIPTION FACTOR SP1;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; BINDING SITE; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MEDIATOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CARCINOMA; CYCLOOXYGENASE 2; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MCF-7 CELLS; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84868015193     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24136     Document Type: Article

References (21)

1. Bae IH, Park MJ, Yoon SH, Kang SW, Lee SS, Choi KM, Um HD. 2006. Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. Cancer Res 66:4991-4994.
2. Barnes NL, Warnberg F, Farnie G, White D, Jiang W, Anderson E, Bundred NJ. 2007. Cyclooxygenase-2 inhibition: Effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer. Br J Cancer 96:575-582.
3. Bonello MR, Khachigian LM. 2004. Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter. J Biol Chem 279:2377-2382.
4. Chuang JY, Wang YT, Yeh SH, Liu YW, Chang WC, Hung JJ. 2008. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol Biol Cell 19:1139-1151.
5. Costa C, Soares R, Reis-Filho JS, Leitao D, Amendoeira I, Schmitt FC. 2002. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol 55:429-434.
6. Courey AJ, Tjian R. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898.
7. Denkert C, Winzer KJ, Muller BM, Weichert W, Pest S, Kobel M, Kristiansen G, Reles A, Siegert A, Guski H, Hauptmann S. 2003. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. Cancer 97:2978-2987.
8. Dillon RL, Muller WJ. 2010. Distinct biological roles for the AKT family in mammary tumor progression. Cancer Res 70:4260-4264.
9. Haidweger E, Novy M, Rotheneder H. 2001. Modulation of Sp1 activity by a cyclin A/CDK complex. J Mol Biol 306:201-211.
10. Hsu MC, Chang HC, Hung WC. 2008. Overexpression of Jab1 in hepatocellular carcinoma and its inhibition by peroxisome proliferator-activated receptor-gamma ligands in vitro and in vivo. Clin Cancer Res 14:4045-4052.
11. Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, Yu Y, Cao X. 2007. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. Mol Immunol 46:242-249.
12. Milanini-Mongiat J, Pouyssegur J, Pages G. 2002. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: Their implication in vascular endothelial growth factor gene transcription. J Biol Chem 277:20631-20639.
13. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, Zlotnik A. 2001. Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50-56.
14. Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. 2000. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem 275:36108-36115.
15. Pan MR, Hou MF, Chang HC, Hung WC. 2008. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. J Biol Chem 283:11155-11163.
16. Pan MR, Chang HC, Wu YC, Huang CC, Hung WC. 2009. Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1to suppress NF-kB-induced CCR7. J Biol Chem 284:2746-2754.
17. Pore N, Liu S, Shu HK, Li B, Haas-Kogan D, Stokoe D, Milanini-Mongiat J, Pages G, O'Rourke DM, Bernhard E, Maity A. 2004. Sp1 is involved in AKT-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 15:4841-4853.
18. Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. 2006. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res 66:3197-3204.
19. Smith WL, DeWitt DL, Garavito RM. 2000. Cyclooxygenases: Structural, cellular, and molecular biology. Annu Rev Biochem 69:145-182.
20. Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, Chen M, Pallen CJ, Dunn SE. 2005. Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene 24:4281-4292.
21. Tan NY, Khachigian LM. 2009. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 29:2483-2488.