Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence

Journal of Human Genetics

Volumn 57, Issue 10, 2012, Pages 670-675

  Zhang, Huiping ^a,b   Herman, Aryeh I ^a,b   Kranzler, Henry R ^c   Anton, Raymond F ^d   Simen, Arthur A ^a   Gelernter, Joel ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

alcohol dependence (AD); bisulfite sequencing; childhood adversity; comorbid drug dependence; m opioid receptor gene(OPRM1); promoter CpG methylation

Indexed keywords

ALCOHOL; BISULFITE; GENOMIC DNA; ILLICIT DRUG; MU OPIATE RECEPTOR;

ADULT; AGE; ALCOHOL INTOXICATION; ALCOHOLISM; ARTICLE; CASE CONTROL STUDY; CHILDHOOD; CHILDHOOD ADVERSITY; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; DNA SEQUENCE; EUROPEAN AMERICAN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; SEX; TRANSCRIPTION INITIATION SITE;

ADULT; ALCOHOLISM; CASE-CONTROL STUDIES; COCAINE-RELATED DISORDERS; COMORBIDITY; CPG ISLANDS; DNA METHYLATION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME, HUMAN; HUMANS; MALE; MARIJUANA ABUSE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROMOTER REGIONS, GENETIC; RECEPTORS, OPIOID, MU; RISK FACTORS; SEQUENCE ANALYSIS, DNA;

EID: 84867974078     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.98     Document Type: Article

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