Critical role of Toll-like receptor 2 in Bacteroides fragilis-mediated immune responses in murine peritoneal mesothelial cells

Microbiology and Immunology

Volumn 56, Issue 11, 2012, Pages 782-788

  Kim, Tae Hyoun ^a   Lee, Kyung Bok ^b   Kang, Min Jung ^b   Park, Jong Hwan ^b  

^a Seoul National University   (South Korea)

^b Konyang University   (South Korea)

Author keywords

Bacteroides fragilis; Immune responses; Peritoneal mesothelial cell; Toll like receptor 2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHEMOKINE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTEROIDES FRAGILIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; MESOTHELIUM CELL; MOUSE; NONHUMAN; PERITONEUM CELL; PHENOTYPE; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BACTEROIDES FRAGILIS; BLOTTING, WESTERN; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PERITONEUM; TOLL-LIKE RECEPTOR 2;

BACTEROIDES FRAGILIS; MURINAE;

EID: 84867970939     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2012.00505.x     Document Type: Article

References (28)

1. Mutsaers S.E. (2004) The mesothelial cell. Int J Biochem Cell Biol 36: 9-16.
2. Colmont C.S., Raby A.C., Dioszeghy V., Lebouder E., Foster T.L., Jones S.A., Labéta M.O., Fielding C.A., Topley N. (2011) Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrol Dial Transplant 26: 4079-90.
3. Hausmann M.J., Rogachev B., Weiler M., Chaimovitz C., Douvdevani A. (2000) Accessory role of human peritoneal mesothelial cells in antigen presentation and T-cell growth. Kidney Int 57: 476-86.
4. Kawai T., Akira S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-84.
5. Akira S., Uematsu S., Takeuchi O. (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
6. Kato S., Yuzawa Y., Tsuboi N., Maruyama S., Morita Y., Matsuguchi T., Matsuo S. (2004) Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. J Am Soc Nephrol 15: 1289-99.
7. Park J.H., Kim Y.G., Shaw M., Kanneganti T.D., Fujimoto Y., Fukase K., Inohara N., Núñez G. (2007) Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol 179: 514-21.
8. Mancuso G., Midiri A., Biondo C., Beninati C., Gambuzza M., Macrì D., Bellantoni A., Weintraub A., Espevik T., Teti G. (2005) Bacteroides fragilis-derived lipopolysaccharide produces cell activation and lethal toxicity via toll-like receptor 4. Infect Immun 73: 5620-7.
9. Pumbwe L., Skilbeck C.A., Wexler H.M. (2006) The Bacteroides fragilis cell envelope: quarterback, linebacker, coach-or all three Anaerobe 12: 211-20.
10. Simon G.L., Gorbach S.L. (1984) Intestinal flora in health and disease. Gastroenterology 86: 174-93.
11. Round J.L., Lee S.M., Li J., Tran G., Jabri B., Chatila T.A., Mazmanian S.K. (2011) The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332: 974-7.
12. Alhawi M., Stewart J., Erridge C., Patrick S., Poxton I.R. (2009) Bacteroides fragilis signals through Toll-like receptor (TLR) 2 and not through TLR4. J Med Microbiol 58: 1015-22.
13. Topley N., Brown Z., Jörres A., Westwick J., Davies M., Coles G.A., Williams J.D. (1993) Human peritoneal mesothelial cells synthesize interleukin-8. Synergistic induction by interleukin-1 beta and tumor necrosis factor-alpha. Am J Pathol 142: 1876-86.
14. Li F.K., Davenport A., Robson R.L., Loetscher P., Rothlein R., Williams J.D., Topley N. (1998) Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression. Kidney Int 54: 2170-83.
15. Liberek T., Topley N., Luttmann W., Williams J.D. (1996) Adherence of neutrophils to human peritoneal mesothelial cells: role of intercellular adhesion molecule-1. J Am Soc Nephrol 7: 208-17.
16. Gary Lee Y.C., Melkerneker D., Thompson P.J., Light R.W., Lane K.B. (2002) Transforming growth factor beta induces vascular endothelial growth factor elaboration from pleural mesothelial cells in vivo and in vitro. Am J Respir Crit Care Med 165: 88-94.
17. Poltorak A., Smirnova I., Clisch R., Beutler B. (2000) Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J Endotoxin Res 6: 51-6.
18. Lorenz E., Patel D.D., Hartung T., Schwartz D.A. (2002) Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun 70:4892-6.
19. Hasegawa M., Yang K., Hashimoto M., Park J.H., Kim Y.G., Fujimoto Y., Nuñez G., Fukase K., Inohara N. (2006) Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J Biol Chem 281: 29054-63.
20. Wang Q., McLoughlin R.M., Cobb B.A., Charrel-Dennis M., Zaleski K.J., Golenbock D., Tzianabos A.O., Kasper D.L. (2006) A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med 203: 2853-63.
21. Poltorak A., Ricciardi-Castagnoli P., Citterio S., Beutler B. (2000) Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc Natl Acad Sci U S A 97: 2163-7.
22. Hirschfeld M., Weis J.J., Toshchakov V., Salkowski C.A., Cody M.J., Ward D.C., Qureshi N., Michalek S.M., Vogel S.N. (2001) Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 69: 1477-82.
23. Werts C., Tapping R.I., Mathison J.C., Chuang T.H., Kravchenko V., Saint Girons I., Haake D.A., Godowski P.J., Hayashi F., Ozinsky A., Underhill D.M., Kirschning C.J., Wagner H., Aderem A., Tobias P.S., Ulevitch R.J. (2001) Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2:346-52.
24. Erridge C., Bennett-Guerrero E., Poxton I.R. (2002) Structure and function of lipopolysaccharides. Microbes Infect 4: 837-51.
25. Weintraub A., Zähringer U., Wollenweber H.W., Seydel U., Rietschel E.T. (1989) Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide. Eur J Biochem 183: 425-31.
26. Erridge C., Pridmore A., Eley A., Stewart J., Poxton I.R. (2004) Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2. J Med Microbiol 53: 735-40.
27. Cohen-Poradosu R., McLoughlin R.M., Lee J.C., Kasper D.L. (2011) Bacteroides fragilis-stimulated interleukin-10 contains expanding disease. J Infect Dis 204: 363-71.
28. Inohara N., Chamaillard M., McDonald C., Nuñez G. (2005) NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74: 355-83.