Serum lactate and procalcitonin measurements in emergency room for the diagnosis and risk-stratification of patients with suspected infection

Biomarkers

Volumn 17, Issue 7, 2012, Pages 590-596

  Freund, Yonathan ^a,b   Delerme, Samuel ^a   Goulet, Hélène ^a   Bernard, Maguy ^a,c   Riou, Bruno ^a,b   Hausfater, Pierre ^a,b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Diagnosis; ED; Lactate; Procalcitonin; Prognosis; Sepsis; Septic shock

Indexed keywords

LACTIC ACID; PROCALCITONIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CALCITONIN BLOOD LEVEL; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HUMAN; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; RISK; SEPSIS; SEPTIC SHOCK; STRATIFIED SAMPLE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AREA UNDER CURVE; BIOLOGICAL MARKERS; CALCITONIN; COHORT STUDIES; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITALIZATION; HUMANS; INTENSIVE CARE UNITS; LACTIC ACID; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROTEIN PRECURSORS; RISK ASSESSMENT; ROC CURVE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

EID: 84867937371     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2012.704645     Document Type: Article

References (30)

1. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. (2009). Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 32:35-39.
2. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. (1993). High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341:515-518.
3. Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL. (1996). Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 171:221-226.
4. Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, Schortgen F, Lasocki S, Veber B, Dehoux M, Bernard M, Pasquet B, Rénier B, Brun-Buisson C, Chastre J, Wolff M; PRORATA trial group. (2010). Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): A multicentre randomised controlled trial. Lancet 375:463-474.
5. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, Ḿler B. (2004). Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial. Lancet 363:600-607.
6. Claessens YE, Schmidt J, Batard E, Grabar S, Jegou D, Hausfater P, Kierzek G, Guéin S, Pourriat JL, Dhainaut JF, Ginsburg C; BIS Study Group. (2010a). Can C-reactive protein, procalcitonin and mid-regional pro-atrial natriuretic peptide measurements guide choice of in-patient or out-patient care in acute pyelonephritis? Biomarkers In Sepsis (BIS) multicentre study. Clin Microbiol Infect 16:753-760.
7. Claessens YE, Mathevon T, Kierzek G, Grabar S, Jegou D, Batard E, Loyer C, Davido A, Hausfater P, Robert H, Lavagna-Perez L, Bernot B, Plaisance P, Leroy C, Renaud B. (2010b). Accuracy of C-reactive protein, procalcitonin, and mid-regional pro-atrial natriuretic peptide to guide site of care of community-acquired pneumonia. Intensive Care Med 36:799-809.
8. Claeys R, Vinken S, Spapen H, ver Elst K, Decochez K, Huyghens L, Gorus FK. (2002). Plasma procalcitonin and C-reactive protein in acute septic shock: Clinical and biological correlates. Crit Care Med 30:757-762.
9. Clec'h C, Ferriere F, Karoubi P, Fosse JP, Cupa M, Hoang P, Cohen Y. (2004). Diagnostic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med 32:1166-1169.
10. DeLong ER, DeLong DM, Clarke-Pearson DL. (1988). Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics 44:837-845.
11. Fall PJ, Szerlip HM. (2005). Lactic acidosis: From sour milk to septic shock. J Intensive Care Med 20:255-271.
12. Green JP, Berger T, Garg N, Shapiro NI. (2011). Serum lactate is a better predictor of short-term mortality when stratified by C-reactive protein in adult emergency department patients hospitalized for a suspected infection. Ann Emerg Med 57:291-295.
13. Hausfater P, Garric S, Ayed SB, Rosenheim M, Bernard M, Riou B. (2002). Usefulness of procalcitonin as a marker of systemic infection in emergency department patients: A prospective study. Clin Infect Dis 34:895-901.
14. Hausfater P, Juillien G, Madonna-Py B, Haroche J, Bernard M, Riou B. (2007). Serum procalcitonin measurement as diagnostic and prognostic marker in febrile adult patients presenting to the emergency department. Crit Care 11:R60.
15. Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. (2007). Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med 33:1892-1899.
16. Jansen TC, van Bommel J, Woodward R, Mulder PG, Bakker J. (2009). Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay: A retrospective observational study. Crit Care Med 37:2369-2374.
17. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; International Sepsis Definitions Conference. (2003). 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530-538.
18. Lvovschi V, Arnaud L, Parizot C, Freund Y, Juillien G, Ghillani-Dalbin P, Bouberima M, Larsen M, Riou B, Gorochov G, Hausfater P. (2011). Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: A prospective observational study. PLoS ONE 6:e28870.
19. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. (2009). Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 37:1670-1677.
20. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, Tomlanovich MC. (2004). Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 32:1637-1642.
21. Nguyen HB, Loomba M, Yang JJ, Jacobsen G, Shah K, Otero RM, Suarez A, Parekh H, Jaehne A, Rivers EP. (2010). Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflamm (Lond) 7:6.
22. Phua J, Koay ES, Lee KH. (2008). Lactate, procalcitonin, and aminoterminal pro-B-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock. Shock 29:328-333.
23. Ray P, Le Manach Y, Riou B, Houle TT. (2010). Statistical evaluation of a biomarker. Anesthesiology 112:1023-1040.
24. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. (2001). Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368-1377.
25. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. (2005). Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med 45:524-528.
26. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. (2004). Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A systematic review and meta-analysis. Clin Infect Dis 39:206-217.
27. Ugarte H, Silva E, Mercan D, De Mendonça A, Vincent JL. (1999). Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med 27:498-504.
28. Viallon A, Guyomarc'h S, Marjollet O, Berger C, Carricajo A, Robert F, Laporte S, Lambert C, Page Y, Zéni F, Bertrand JC. (2008). Can emergency physicians identify a high mortality subgroup of patients with sepsis: Role of procalcitonin. Eur J Emerg Med 15:26-33.
29. Vincent JL, Dufaye P, Berŕ J, Leeman M, Degaute JP, Kahn RJ. (1983). Serial lactate determinations during circulatory shock. Crit Care Med 11:449-451.
30. Vorwerk C, Loryman B, Coats TJ, Stephenson JA, Gray LD, Reddy G, Florence L, Butler N. (2009). Prediction of mortality in adult emergency department patients with sepsis. Emerg Med J 26:254-258.