Reveals new lung adenocarcinoma cancer genes based on gene expression

European Review for Medical and Pharmacological Sciences

Volumn 16, Issue 9, 2012, Pages 1249-1256

  Lin, Z F ^a   Shen, X Y ^b   Lu, F Z ^b   Ruan, Z ^a   Huang, H L ^a   Zhen, J ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

EGF Like domain; Lung adenocarcinoma; Meta Analysis; Pathway

Indexed keywords

CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR; MEMBRANE PROTEIN; PROTEIN MUC17; PROTEIN NEL; PROTEIN NGX6; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLADDER CANCER; BLOOD CLOTTING; CELL PROLIFERATION; COMPLEMENT SYSTEM; DOWN REGULATION; FALSE POSITIVE RESULT; FOCAL ADHESION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; LUNG ADENOCARCINOMA; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PREDICTIVE VALUE; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TUMOR GENE; UPREGULATION; UROGENITAL SYSTEM;

ADENOCARCINOMA; CELL ADHESION MOLECULES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; HYALURONOGLUCOSAMINIDASE; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; SEMAPHORINS;

EID: 84867931300     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. TRAVIS WD, TRAVIS LB, DEVESA SS. Lung cancer. Cancer 1995; 75: 191-202.
2. DING L, GETZ G, WHEELER DA, MARDIS ER, MCLELLAN MD, CIBULSKIS K, SOUGNEZ C, GREULICH H, MUZNY DM, MORGAN MB, FULTON L, FULTON RS, ZHANG Q, WENDL MC, LAWRENCE MS, LARSON DE, CHEN K, DOOLING DJ, SABO A, HAWES AC, SHEN H, JHANGIANI SN, LEWIS LR, HALL O, ZHU Y, MATHEW T, REN Y, YAO J, SCHERER SE, CLERC K, METCALF GA, NG B, MILOSAVLJEVIC A, GONZALEZ-GARAY ML, OSBORNE JR, MEYER R, SHI X, TANG Y, KOBOLDT DC, LIN L, ABBOTT R, MINER TL, POHL C, FEWELL G, HAIPEK C, SCHMIDT H, DUNFORD-SHORE BH, KRAJA A, CROSBY SD, SAWYER CS, VICKERY T, SANDER S, ROBINSON J, WINCKLER W, BALDWIN J, CHIRIEAC LR, DUTT A, FENNELL T, HANNA M, JOHNSON BE, ONOFRIO RC, THOMAS RK, TONON G, WEIR BA, ZHAO X, ZIAUGRA L, ZODY MC, GIORDANO T, ORRINGER MB, ROTH JA, SPITZ MR, WISTUBA, II, OZENBERGER B, GOOD PJ, CHANG AC, BEER DG, WATSON MA, LADANYI M, BRODERICK S, YOSHIZAWA A, TRAVIS WD, PAO W, PROVINCE MA, WEINSTOCK GM, VARMUS HE, GABRIEL SB, LANDER ES, GIBBS RA, MEYERSON M, WILSON RK. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008; 455: 1069-1075.
3. WEIR BA, WOO MS, GETZ G, PERNER S, DING L, BEROUKHIM R, LIN WM, PROVINCE MA, KRAJA A, JOHNSON LA, SHAH K, SATO M, THOMAS RK, BARLETTA JA, BORECKI IB, BRODERICK S, CHANG AC, CHIANG DY, CHIRIEAC LR, CHO J, FUJII Y, GAZDAR AF, GIORDANO T, GREULICH H, HANNA M, JOHNSON BE, KRIS MG, LASH A, LIN L, LINDEMAN N, MARDIS ER, MCPHERSON JD, MINNA JD, MORGAN MB, NADEL M, ORRINGER MB, OSBORNE JR, OZENBERGER B, RAMOS AH, ROBINSON J, ROTH JA, RUSCH V, SASAKI H, SHEPHERD F, SOUGNEZ C, SPITZ MR, TSAO MS, TWOMEY D, VERHAAK RG, WEINSTOCK GM, WHEELER DA, WINCKLER W, YOSHIZAWA A, YU S, ZAKOWSKI MF, ZHANG Q, BEER DG, WISTUBA II, WATSON MA, GARRAWAY LA, LADANYI M, TRAVIS WD, PAO W, RUBIN MA, GABRIEL SB, GIBBS RA, VARMUS HE, WILSON RK, LANDER ES, MEYERSON M. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007; 450: 893-898.
4. CHEE M, YANG R, HUBBELL E, BERNO A, HUANG XC, STERN D, WINKLER J, LOCKHART DJ, MORRIS MS, FODOR SP. Accessing genetic information with high-Density DNA arrays. Science 1996; 274: 610-614.
5. KHAN J, WEI JS, RINGNER M, SAAL LH, LADANYI M, WESTERMANN F, BERTHOLD F, SCHWAB M, ANTONESCU CR, PETERSON C, MELTZER PS. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 2001; 7: 673-679.
6. WANG GP, YE Y, YANG XQ, LIAO HY, ZHAO CG, LIANG S. Expression-Based in silico screening of candidate therapeutic compounds for lung adenocarcinoma. Plos One 2011; 6: E14573.
7. SPIES M, DASU MR, SVRAKIC N, NESIC O, BARROW RE, PEREZ-POLO JR, HERNDON DN. Gene expression analysis in burn wounds of rats. Am J Physiol Regul Integr Comp Physiol 2002; 283: R918-930.
8. GUO QM. DNA microarray and cancer. Curr Opin Oncol 2003; 15: 36.
9. LI R, WANG H, BEKELE BN, YIN Z, CARAWAY NP, KATZ RL, STASS SA, JIANG F. Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene 2006; 25: 2628-2635.
10. MCDONIELS-SILVERS AL, NIMRI CF, STONER GD, LUBET RA, YOU M. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res 2002; 8: 1127-1138.
11. HONG F, BREITLING R, MCENTEE CW, WITTNER BS, NEMHAUSER JL, CHORY J. Rankprod: A bioconductor package for detecting differentially expressed genes in meta-Analysis. Bioinformatics 2006; 22: 2825-2827.
12. SMYTH GK. Linear models and empirical bayes methods for assessing differentiaexpression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article3. Epub 2004 Feb 12.
13. HUANG DA W, SHERMAN BT, LEMPICKI RA. Systematic and integrative analysis of large gene lists using david bioinformatics resources.Nat Protoc 2009; 4: 44-57.
14. HUNTER S, APWEILER R, ATTWOOD TK, BAIROCH A, BATEMAN A, BINNS D, BORK P, DAS U, DAUGHERTY L, DUQUENNE L, FINN RD, GOUGH J, HAFT D, HULO N, KAHN D, KELLY E, LAUGRAUD A, LETUNIC I, LONSDALE D, LOPEZ R, MADERA M, MASLEN J, MCANULLA C, MCDOWALL J, MISTRY J, MITCHELL A, MULDER N, NATALE D, ORENGO C, QUINN AF, SELENGUT JD, SIGRIST CJ, THIMMA M, THOMAS PD, VALENTIN F, WILSON D, WU CH, YEATS C. Interpro: The integrative protein signature database. Nucleic Acids Res 2009; 37: D211-215.
15. DRAGHICI S, KHATRI P, TARCA AL, AMIN K, DONE A, VOICHITA C, GEORGESCU C, ROMERO R. A systems biology approach for pathway level analysis. Genome Res 2007; 17: 1537-1545.
16. HONG F, BREITLING R. A comparison of meta-Analysis methods for detecting differentially expressed genes in microarray experiments. Bioinformatics 2008; 24: 374-382.
17. CHENG CY, PEREVEDENTSEVA E, TU JS, CHUNG PH, CHENG CL, LIU KK, CHAO JI, CHEN PH, CHANG CC. Direct and in vitro observation of growth hormone receptor molecules in a549 human lung epithelial cells by nanodiamond labeling. Appl Phys Lett 2007; 90: 16390
18. SUN H, ZHENG Y, OU W, FANG Q, LI P, YE X, ZHANG B, YANG H, WANG S. Association between hormone receptor expression and epidermal growth factor receptor mutation in patients operated on for non-Small cell lung cancer.Ann Thorac Surg 2011; 91: 1562-1567.
19. MA Z, DONG A, KONG M, QIAN J. Silencing of the type 1 insulin-Like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma a549 cells. Cell Mol Biol Lett 2007; 12: 556-572.
20. GARBER ME, TROYANSKAYA OG, SCHLUENS K, PETERSEN S, THAESLER Z, PACYNA-GENGELBACH M, VAN DE RIJN M, ROSEN GD, PEROU CM, WHYTE RI. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A 2001; 98: 13784-13789.
21. YE J, HAMEED O, FINDEIS-HOSEY J, FAN L, LI F, MCMAHON L, YANG Q, WANG H, XU H. Diagnostic utility of pax8, ttf-1 and napsin a for discriminating metastatic carcinoma from primary adenocarcinoma of the lung. Biotech Histochem 2012: 87: 30-34.
22. OHTSUKA T, SHIOMI T, SHIMODA M, KODAMA T, AMOUR A, MURPHY G, OHUCHI E, KOBAYASHI K, OKADA Y. Adam28 is overexpressed in human non-Small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. Int J Cancer 2006; 118: 263-273.
23. MINO N, MIYAHARA R, NAKAYAMA E, TAKAHASHI T, TAKAHASHI A, IWAKIRI S, SONOBE M, OKUBO K, HIRATA T, SEHARA A. A disintegrin and metalloprotease 12 (adam12) is a prognostic factor in resected pathological stage i lung adenocarcinoma. J Surg Oncol 2009; 100: 267-272.
24. DALLOL A, DA SILVA NF, VIACAVA P, MINNA JD, BIECHE I, MAHER ER, LATIF F. Slit2, a human homologue of the drosophila slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res 2002; 62: 5874-5880.
25. HURET JL, DESSEN P, BERNHEIM A. Atlas of genetics and cytogenetics in oncology and haematology, year 2003. Nucleic Acids Res 2003; 31: 272-274.
26. MA J, ZHOU J, FAN S, WANG L, LI X, YAN Q, ZHOU M, LIU H, ZHANG Q, ZHOU H. Role of a novel egf-Like domain-Containing gene ngx6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis 2005; 26: 281-291.
27. SENAPATI S, HO SB, SHARMA P, DAS S, CHAKRABORTY S, KAUR S, NIEHANS G, BATRA SK. Expression of intestinal muc17 membrane-Bound mucin in inflammatory and neoplastic diseases of the colon. J Clin Pathol 2010; 63: 702-707.
28. JIN Z, MORI Y, YANG J, SATO F, ITO T, CHENG Y, PAUN B, HAMILTON J, KAN T, OLARU A, DAVID S, AGARWAL R, ABRAHAM JM, BEER D, MONTGOMERY E, MELTZER SJ. Hypermethylation of the nel-Like 1 gene is a common and early event and is associated with poor prognosis in early-Stage esophageal adenocarcinoma. Oncogene 2007; 26: 6332-6340.
29. BRANNAN JM, SEN B, SAIGAL B, PRUDKIN L, BEHRENS C, SOLIS L, DONG W, BEKELE BN, WISTUBA I, JOHNSON FM. Epha2 in the early pathogenesis and progression of non-Small cell lung cancer. Cancer Prev Res 2009; 2: 1039-1049.
30. CASTRO-RIVERA E, RAN S, BREKKEN RA, MINNA JD. Semaphorin 3b inhibits the phosphatidylinositol 3-Kinase/akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res 2008; 68: 8295-8303.
31. LU TP, TSAI MH, LEE JM, HSU CP, CHEN PC, LIN CW, SHIH JY, YANG PC, HSIAO CK, LAI LC, CHUANG EY. Identification of a novel biomarker, sema5a, for non-Small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev 2010; 19: 2590-2597.
32. DELLOYE-BOURGEOIS C, BRAMBILLA E, COISSIEUX MM, GUENEBEAUD C, PEDEUX R, FIRLEJ V, CABON F, BRAMBILLA C, MEHLEN P, BERNET A. Interference with netrin-1 and tumor cell death in non̈csmall cell lung cancer. J Natl Cancer Inst 2009; 101: 237-247.
33. SALGIA R, LI JL, EWANIUK DS, WANG YB, SATTLER M, CHEN WC, RICHARDS W, PISICK E, SHAPIRO GI, ROLLINS BJ, CHEN LB, GRIFFIN JD, SUGARBAKER DJ. Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.Oncogene 1999; 18: 67-77.
34. WEI L, YANG Y, ZHANG X, YU Q. Altered regulation of src upon cell detachment protects human lung adenocarcinoma cells from anoikis. Oncogene 2004; 23: 9052-9061.
35. SU JL, YANG CY, SHIH JY, WEI LH, HSIEH CY, JENG YM, WANG MY, YANG PC, KUO ML. Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. Cancer Res 2006; 66: 2553-2561.
36. CARELLI S, ZADRA G, VAIRA V, FALLENI M, BOTTIGLIERI L, NOSOTTI M, DI GIULIO AM, GORIO A, BOSARI S. Upregulation of focal adhesion kinase in non-Small cell lung cancer. Lung Cancer 2006; 53: 263-271.
37. WANG C, YANG R, YUE D, ZHANG Z. Expression of fak and pten in bronchioloalveolar carcinoma and lung adenocarcinoma. Lung 2009; 187: 104-109.
38. LAU YIN-WAH. Mutation and expression analysis of pten in non-Small cell lung cancer from nonsmokers. HKU Theses Online (HKUTO), 2009.
39. HEO SH, LEE SJ, RYOO HM, PARK JY, CHO JY. Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS. Proteomics 2007; 7: 4292-4302.
40. NARAYANASAMY A, AHN JM, SUNG HJ, KONG DH, HA KS, LEE SY, CHO JY. Fucosylated glycoproteomic approach to identify a complement component 9 associated with squamous cell lung cancer (sqlc). J Proteomics 2011; 74: 2948-2958.
41. KIM KB, YI JS, NGUYEN N, LEE JH, KWON YC, AHN BY, CHO H, KIM YK, YOO HJ, LEE JS, KO JY. Cell-Surface receptor for complement component c1q (gc1qr) is a key regulator for lamellipodia formation and cancer metastasis. J Biol Chem 2011; 286: 23093-23101.
42. OKROJ M, HSU YF, AJONA D, PIO R, BLOM AM. Nonsmall cell lung cancer cells produce a functional set of complement factor i and its soluble cofactors. Mol Immunol 2008; 45: 169-179.
43. AJONA D, HSU YF, CORRALES L, MONTUENGA LM, PIO R. Down-Regulation of human complement factor h sensitizes non-Small cell lung cancer cells to complement attack and reduces in vivo tumor growth. J Immunol 2007; 178: 5991.