Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 411, Issue 4, 2011, Pages 786-791

  Hu, Jiajia ^a   Qin, Kunhua ^a   Zhang, Yan ^a   Gong, Junbo ^b   Li, Na ^a   Lv, Dan ^a   Xiang, Rong ^a   Tan, Xiaoyue ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY   (China)

Author keywords

Breast cancer; Epithelial to mesenchymal transition; Oct4; SOCE; Tumor metastasis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; FIBRONECTIN; GELATINASE A; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP)(PHOSPHORYLATING); OCTAMER TRANSCRIPTION FACTOR 4; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA; STROMAL INTERACTION MOLECULE 1; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CALCIUM TRANSPORT; CANCER CELL; CELL INVASION; CELL LINE; CELL MIGRATION; CELL STRAIN MCF 7; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; MDA MB 231 CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; UPREGULATION; WESTERN BLOTTING;

BREAST NEOPLASMS; CALCIUM; CALCIUM CHANNELS; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MEMBRANE PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; RNA INTERFERENCE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 80051563653     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.025     Document Type: Article

References (30)

1. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., Young R.A. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956.
2. Pan G.J., Chang Z.Y., Scholer H.R., Pei D. Stem cell pluripotency and transcription factor Oct4. Cell Res 2002, 12:321-329.
3. Chambers I., Tomlinson S.R. The transcriptional foundation of pluripotency. Development 2009, 136:2311-2322.
4. de Jong J., Looijenga L.H. Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. Crit. Rev. Oncog. 2006, 12:171-203.
5. Tai M.H., Chang C.C., Kiupel M., Webster J.D., Olson L.K., Trosko J.E. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 2005, 26:495-502.
6. Asadi M.H., Mowla S.J., Fathi F., Aleyasin A., Asadzadeh J., Atlasi Y. OCT4B1, a novel spliced variant of OCT4 is highly expressed in gastric cancer and acts as an antiapoptotic factor. Int. J. Cancer 2010.
7. Hochedlinger K., Yamada Y., Beard C., Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005, 121:465-477.
8. Karoubi G., Gugger M., Schmid R., Dutly A. OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. Interact. Cardiovasc. Thorac. Surg. 2009, 8:393-397.
9. Hu T., Liu S., Breiter D.R., Wang F., Tang Y., Sun S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res. 2008, 68:6533-6540.
10. Jin T., Branch D.R., Zhang X., Qi S., Youngson B., Goss P.E. Examination of POU homeobox gene expression in human breast cancer cells. Int. J. Cancer 1999, 81:104-112.
11. Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119:1420-1428.
12. Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 2008, 14:818-829.
13. Huber M.A., Azoitei N., Baumann B., Grunert S., Sommer A., Pehamberger H., Kraut N., Beug H., Wirth T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 2004, 114:569-581.
14. Papageorgis P., Lambert A.W., Ozturk S., Gao F., Pan H., Manne U., Alekseyev Y.O., Thiagalingam A., Abdolmaleky H.M., Lenburg M., Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010, 70:968-978.
15. Lourido S., Shuman J., Zhang C., Shokat K.M., Hui R., Sibley L.D. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature 2010, 465:359-362.
16. T. Balla, STIM and Orai: the long-awaited constituents of store-operated calcium entry, Trends Pharmacol. Sci. (2009).
17. Yang S., Zhang J.J., Huang X.-Y. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 2009, 15:124-134.
18. Feske S. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 2007, 7:690-702.
19. Roberts-Thomson S.J., Peters A.A., Grice D.M., Monteith G.R. ORAI-mediated calcium entry: mechanism and roles, diseases and pharmacology. Pharmacol. Ther. 2010, 127:121-130.
20. 2+ entry. Nat. Cell Biol. 2009, 11:669-677.
21. Yu F., Sun L., Courjaret R., Machaca K. Role of the STIM1 C-terminal domain in STIM1 clustering. J. Biol. Chem. 2011, 286:8375-8384.
22. 2+ measured with fura-2. Br. J. Pharmacol. 1991, 104:373-378.
23. Kim J.H., Jang Y.S., Eom K.S., Hwang Y.I., Kang H.R., Jang S.H., Kim C.H., Park Y.B., Lee M.G., Hyun I.G., Jung K.S., Kim D.G. Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells. J. Korean Med. Sci. 2007, 22:898-904.
24. Meindl-Beinker N.M., Dooley S. Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis. J. Gastroenterol. Hepatol. 2008, 23(Suppl 1):S122-127.
25. Chang L.H., Chen C.H., Huang D.Y., Pai H.C., Pan S.L., Teng C.M. Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. J. Cell. Physiol. 2011, 226:1060-1068.
26. Archiniegas E., Neves C.Y., Candelle D., Cardier J.E. Thrombin and its protease-activated receptor-1 (PAR1) participate in the endothelial-mesenchymal transdifferentiation process. DNA Cell Biol. 2004, 23:815-825.
27. Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J. Clin. Invest. 2009, 119:1417-1419.
28. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
29. Li R., Liang J., Ni S., Zhou T., Qing X., Li H., He W., Chen J., Li F., Zhuang Q., Qin B., Xu J., Li W., Yang J., Gan Y., Qin D., Feng S., Song H., Yang D., Zhang B., Zeng L., Lai L., Esteban M.A., Pei D. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010, 7:51-63.
30. Kunzelmann K. Ion channels and cancer. J. Membr. Biol. 2005, 205:159-173.