Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 43, 2012, Pages 17573-17578

  Chou, Stella T ^a   Byrska Bishop, Marta ^b   Tober, Joanna M ^c   Yao, Yu ^a   VanDorn, Daniel ^a   Opalinska, Joanna B ^a   Mills, Jason A ^a   Choi, John Kim ^a   Speck, Nancy A ^c   Gadue, Paul ^a   Hardison, Ross C ^b   Nemiroff, Richard L ^d   French, Deborah L ^a   Weiss, Mitchell J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPHORIN A; KRUPPEL LIKE FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTOME;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DISEASE ASSOCIATION; ERYTHROPOIESIS; FETUS; FIBROBLAST; FLOW CYTOMETRY; HEMATOPOIESIS; HUMAN; HUMAN CELL; MEGAKARYOCYTE; MICROARRAY ANALYSIS; MYELOPOIESIS; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRISOMY 21; UPREGULATION; YOLK SAC;

CELL DIFFERENTIATION; DOWN SYNDROME; GENE EXPRESSION PROFILING; HEMATOPOIESIS; HUMANS; PLURIPOTENT STEM CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84867903663     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211175109     Document Type: Article

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