QTL mapping of the production of wine aroma compounds by yeast

BMC Genomics

Volumn 13, Issue 1, 2012, Pages

  Steyer, Damien ^a,b,c   Ambroset, Chloe ^d,e,f   Brion, Christian ^d,e,f   Claudel, Patricia ^a,b   Delobel, Pierre ^d,e,f   Sanchez, Isabelle ^d,e,f   Erny, Claude ^g   Blondin, Bruno ^d,e,f   Karst, Francis ^a,b   Legras, Jean Luc ^d,e,f  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Twistaroma   (France)

^d SPO   (France)

^e MONTPELLIER SUPAGRO   (France)

^f UNIV MONTPELLIER   (France)

^g UNIVERSITÉ DE HAUTE ALSACE   (France)

Author keywords

2 phenyl ethanol; ABZ1; Citronellol; Ethyl esters; Farnesene; Nerolidol; PDR8; PLB2; QDR2; QTL mapping; Rose oxide; Saccharomyces cerevisiae; Wine aroma

Indexed keywords

2 PHENYL ETHANOL; 2 PHENYLETHYLACETATE; ACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; ALKANOIC ACID; CITRONELLOL; DECANOIC ACID; DECANOIC ACID DERIVATIVE; ETHYL 3 HYDROXYDECANOIC ACID; ETHYL 9 DECANOATE; ETHYLDECANOATE; ETHYLHEXANOATE; ETHYLMYRISTATE; ETHYLOCTANOATE; FARNESOL; GERANIOL; GERANYL ACETATE; HEXANOIC ACID; ISOBUTANOL; ISOPENTYL ACETATE; ISOPENTYL ALCOHOL; LINALOOL; MYRISTIC ACID; NEROL; NEROLIDOL; OCTANOIC ACID; OXIDE; ROSE OXIDE; TERPINEOL; UNCLASSIFIED DRUG;

ABZ1 GENE; AROMA; ARTICLE; BIOTECHNOLOGICAL PRODUCTION; FUNGAL GENE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; GRAPE; HEMIZYGOTE; NONHUMAN; PDR8 GENE; PHENOTYPE; PLB2 GENE; QUANTITATIVE TRAIT LOCUS MAPPING; WINE; YEAST;

ALLELES; CHROMOSOME MAPPING; FERMENTATION; GENE DELETION; GENETIC VARIATION; METABOLIC NETWORKS AND PATHWAYS; MONOTERPENES; ODORS; ORGANIC CHEMICALS; QUANTITATIVE TRAIT LOCI; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; VITIS; WINE;

SACCHAROMYCES CEREVISIAE; VITACEAE;

EID: 84867900218     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-13-573     Document Type: Article

References (56)

1. Young ND. QTL mapping and quantitative disease resistance in plants. Annu Rev Phytopathol 1996, 34:479-501. 10.1146/annurev.phyto.34.1.479, 15012553.
2. Deutschbauer AM, Davis RW. Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat Genet 2005, 37:1333-1340. 10.1038/ng1674, 16273108.
3. Sinha H, Nicholson BP, Steinmetz LM, McCusker JH. Complex genetic interactions in a quantitative trait locus. PLoS genetics 2006, 2:e13. 10.1371/journal.pgen.0020013, 1359075, 16462944.
4. Steinmetz LM, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. Dissecting the architecture of a quantitative trait locus in yeast. Nature 2002, 416:326-330. 10.1038/416326a, 11907579.
5. Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet 2007, 39:496-502. 10.1038/ng1991, 17334364.
6. Demogines A, Smith E, Kruglyak L, Alani E. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS genetics 2008, 4:e1000123. 10.1371/journal.pgen.1000123, 2440805, 18617998.
7. Ansel J, Bottin H, Rodriguez-Beltran C, Damon C, Nagarajan M, Fehrmann S, François J, Yvert G. Cell-to-cell stochastic variation in gene expression is a complex genetic trait. PLoS genetics 2008, 4:e1000049. 10.1371/journal.pgen.1000049, 2289839, 18404214.
8. Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature 2010, 464:1039-1042. 10.1038/nature08923, 2862354, 20393561.
9. Cubillos FA, Billi E, Zörgö E, Parts L, Fargier P, Omholt S, Blomberg A, Warringer J, Louis EJ, Liti G. Assessing the complex architecture of polygenic traits in diverged yeast populations. Mol Ecol 2011, 20:1401-1413. 10.1111/j.1365-294X.2011.05005.x, 21261765.
10. Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 2003, 35:57-64.
11. Ambroset C, Petit M, Brion C, Sanchez I, Delobel P, Guérin C, Chiapello H, Nicolas P, Bigey F, Dequin S, Blondin B. Deciphering the Molecular Basis of Wine Yeast Fermentation Traits Using a Combined Genetic and Genomic Approach. G3 2011, 1:263-281. 2011, 3276144, 22384338.
12. Marullo P, Yvert G, Bely M, Aigle M, Dubourdieu D. Efficient use of DNA molecular markers to construct industrial yeast strains. FEMS yeast research 2007, 7:1295-1306. 10.1111/j.1567-1364.2007.00281.x, 17888000.
13. Marullo P, Mansour C, Dufour M, Albertin W, Sicard D, Bely M, Dubourdieu D. Genetic improvement of thermo-tolerance in wine Saccharomyces cerevisiae strains by a backcross approach. FEMS yeast research 2009, 9:1148-1160. 10.1111/j.1567-1364.2009.00550.x, 19758333.
14. Katou T, Namise M, Kitagaki H, Akao T, Shimoi H. QTL mapping of sake brewing characteristics of yeast. J Biosci Bioeng 2009, 107:383-393. 10.1016/j.jbiosc.2008.12.014, 19332297.
15. Hu XH, Wang MH, Tan T, Li JR, Yang H, Leach L, Zhang RM, Luo ZW. Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae. Genetics 2007, 175:1479-1487. 1840089, 17194785.
16. Marullo P, Aigle M, Bely M, Masneuf-Pomarède I, Durrens P, Dubourdieu D, Yvert G. Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cerevisiae strains. FEMS yeast research 2007, 7:941-952. 10.1111/j.1567-1364.2007.00252.x, 17537182.
17. Loscos N, Hernandez-Orte P, Cacho J, Ferreira V. Release and formation of varietal aroma compounds during alcoholic fermentation from nonfloral grape odorless flavor precursors fractions. J Agric Food Chem 2007, 55:6674-6684. 10.1021/jf0702343, 17616208.
18. Ferreira V, Lopez R, Cacho JF. Quantitative determination of the odorants of young red wines from different grape varieties. J Sci Food Agric 2000, 80:1659-1667.
19. Lilly M, Lambrechts MG, Pretorius IS. Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates. Appl Environ Microbiol 2000, 66:744-753. 10.1128/AEM.66.2.744-753.2000, 91891, 10653746.
20. Saerens SMG, Verstrepen KJ, Van Laere SDM, Voet ARD, Van Dijck P, Delvaux FR, Thevelein JM. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem 2006, 281:4446-4456. 10.1074/jbc.M512028200, 16361250.
21. Wondra M, Berovic M. Analyses of Aroma Components of Chardonnay Wine Fermented by Different Yeast Strains. Food Technology and Biotechnology 2001, 39:141-148.
22. Romano P. Function of yeast species and strains in wine flavour. International Journal of Food Microbiology 2003, 86:169-180. 10.1016/S0168-1605(03)00290-3, 12892932.
23. Camarasa C, Sanchez I, Brial P, Bigey F, Dequin S. Phenotypic Landscape of Saccharomyces cerevisiae during Wine Fermentation: Evidence for Origin-Dependent Metabolic Traits. PLoS One 2011, 6:e25147. 10.1371/journal.pone.0025147, 3174997, 21949874.
24. Rossouw D, Naes T, Bauer FF. Linking gene regulation and the exo-metabolome: a comparative transcriptomics approach to identify genes that impact on the production of volatile aroma compounds in yeast. BMC Genomics 2008, 9:530. 10.1186/1471-2164-9-530, 2585593, 18990252.
25. Rossouw D, Jacobson D, Bauer FF. Transcriptional regulation and the diversification of metabolism in wine yeast strains. Genetics 2012, 190:251-261. 10.1534/genetics.111.132720, 3249374, 22042577.
26. Pretorius IS. Gene Technology in Winemaking: New Approaches to an Ancient Art. Agric Conspec Sci 2001, 66:27-47.
27. Duchene E, Legras J-L, Karst F, Merdinoglu D, Claudel P, Jaegli N, Pelsy F. Variation of linalool and geraniol content within two pairs of aromatic and non-aromatic grapevine clones. Australian Journal of Grape and Wine Research 2009, 15:120-130.
28. Hikkel I, Lucau-Danila A, Delaveau T, Marc P, Devaux F, Jacq C. A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J Biol Chem 2003, 278:11427-11432. 10.1074/jbc.M208549200, 12529331.
29. Merkel O, Fido M, Mayr JA, Prüger H, Raab F, Zandonella G, Kohlwein SD, Paltauf F. Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. J Biol Chem 1999, 274:28121-28127. 10.1074/jbc.274.40.28121, 10497163.
30. Akao T, Yashiro I, Hosoyama A, Kitagaki H, Horikawa H, Watanabe D, Akada R, Ando Y, Harashima S, Inoue T, Inoue Y, Kajiwara S, Kitamoto K, Kitamoto N, Kobayashi O, Kuhara S, Masubuchi T, Mizoguchi H, Nakao Y, Nakazato A, Namise M, Oba T, Ogata T, Ohta A, Sato M, Shibasaki S, Takatsume Y, Tanimoto S, Tsuboi H, Nishimura A, Yoda K, Ishikawa T, Iwashita K, Fujita N, Shimoi H. Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no. 7. DNA research: an international journal for rapid publication of reports on genes and genomes 2011, 18:423-434.
31. Borneman AR, Desany BA, Riches D, Affourtit JP, Forgan AH, Pretorius IS, Egholm M, Chambers PJ. Whole-Genome Comparison Reveals Novel Genetic Elements That Characterize the Genome of Industrial Strains of Saccharomyces cerevisiae. PLoS Genetics 2011, 7:e1001287. 10.1371/journal.pgen.1001287, 3033381, 21304888.
32. Novo M, Bigey F, Beyne E, Galeote V, Gavory F, Mallet S, Cambon B, Legras J-L, Wincker P, Casaregola S, Dequin S. Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118. Proc Natl Acad Sci 2009, 106:16333-16338. 10.1073/pnas.0904673106, 2740733, 19805302.
33. Argueso JL, Carazzolle MF, Mieczkowski PA, Duarte FM, Netto OVC, Missawa SK, Galzerani F, Costa GGL, Vidal RO, Noronha MF, Dominska M, Andrietta MGS, Andrietta SR, Cunha AF, Gomes LH, Tavares FCA, Alcarde AR, Dietrich FS, McCusker JH, Petes TD, Pereira GAG. Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Res 2009, 19:2258-2270. 10.1101/gr.091777.109, 2792172, 19812109.
34. McDonald JH, Kreitman M. Adaptive protein evolution at the Adh locus in Drosophila. Nature 1991, 351:652-654. 10.1038/351652a0, 1904993.
35. Oswald M, Fischer M, Dirninger N, Karst F. Monoterpenoid biosynthesis in Saccharomyces cerevisiae. FEMS yeast research 2007, 7:413-421. 10.1111/j.1567-1364.2006.00172.x, 17096665.
36. Guth H. Quantitation and Sensory Studies of Character Impact Odorants of Different White Wine Varieties. J Agric Food Chem 1997, 45:3027-3032.
37. Koslitz S, Renaud L, Kohler M, Wüst M, Chem F, The C, However L. Stereoselective formation of the varietal aroma compound rose oxide during alcoholic fermentation. J Agric Food Chem 2008, 56:1371-1375. 10.1021/jf072518t, 18247534.
38. Muramatsu M, Ohto C, Obata S, Sakuradani E, Shimizu S. Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. J Biosci Bioeng 2009, 108:52-55. 10.1016/j.jbiosc.2009.02.012, 19577192.
39. Aa E, Townsend JP, Adams RI, Nielsen KM, Taylor JW. Population structure and gene evolution in Saccharomyces cerevisiae. FEMS yeast research 2006, 6:702-715. 10.1111/j.1567-1364.2006.00059.x, 16879422.
40. Juchimiuk M, Pasikowska M, Zatorska E, Laudy AE, Smoleńska-Sym G, Palamarczyk G. Defect in dolichol-dependent glycosylation increases sensitivity of Saccharomyces cerevisiae towards anti-fungal drugs. Yeast (Chichester, England) 2010, 27:637-645.
41. Orłowski J, Machula K, Janik A, Zdebska E, Palamarczyk G. Dissecting the role of dolichol in cell wall assembly in the yeast mutants impaired in early glycosylation reactions. Yeast (Chichester, England) 2007, 24:239-252.
42. Grabińska KA, Magnelli P, Robbins PW. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Eukaryotic cell 2007, 6:328-336. 10.1128/EC.00203-06, 1797950, 17142567.
43. Fairn GD, Macdonald K, McMaster CR. A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. J Biol Chem 2007, 282:4868-4874.
44. Langford ML, Hasim S, Nickerson KW, Atkin AL. Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions. Antimicrob Agents Chemother 2010, 54:940-942. 10.1128/AAC.01214-09, 2812148, 19933803.
45. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 2001, 67:2982-2992. 10.1128/AEM.67.7.2982-2992.2001, 92970, 11425711.
46. Palková Z, Váchová L. Life within a community: benefit to yeast long-term survival. FEMS Microbiol Rev 2006, 30:806-824. 10.1111/j.1574-6976.2006.00034.x, 16911045.
47. Cubillos FA, Zia A, Gjuvsland A, TJ, Warringer J, Forsmark A, Durbin R, Omholt SW, Louis EJ, Liti G, Moses A, Blomberg A. Trait Variation in Yeast Is Defined by Population History. PLoS Genetics 2011, 7:e1002111. 10.1371/journal.pgen.1002111, 3116910, 21698134.
48. Bely M, Sablayrolles J-M, Barre P. Automatic detection of assimilable nitrogen deficiencies during alcoholic fermentation in oenological conditions. J Ferment Bioeng 1990, 70:246-252.
49. Coelho E, Rocha S, Delgadillo I, Coimbra M. Headspace-SPME applied to varietal volatile components evolution during Vitis vinifera L. cv. " Baga" ripening. Anal Chim Acta 2006, 563:204-214.
50. Brem RB, Yvert G, Clinton R, Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science (New York, N.Y.) 2002, 296:752-755.
51. R Core Team R: A language and environment for statistical computing, Version 2.15.1. R Foundation for Statistical Computing 2012, R Core Team.
52. Broman KW, Wu H, Sen S, Churchill G. a.: R/qtl: QTL mapping in experimental crosses. Bioinformatics 2003, 19:889-890. 10.1093/bioinformatics/btg112, 12724300.
53. Broman KW, Sen T. b.: A Guide to QTL Mapping with R/qtl 2009, Germany/New York: Springer-Verlag, Berlin/Heidelberg.
54. Legras J-L, Erny C, LeJeune C, Lollier M, Adolphe Y, Demuyter C, Delobel P, Blondin B, Karst F. Saccharomyces cerevisiae activates two different resistance mechanisms when exposed to octanoic and decanoic acids. Appl Environ Microbiol 2010, 76:7526-7535. 10.1128/AEM.01280-10, 2976208, 20851956.
55. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Mol Biol Evol 2011, 28:2731-2739. 10.1093/molbev/msr121, 3203626, 21546353.
56. Kimura M. A simple method for estimating evolutionary rate of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 1980, 16:111-120. 10.1007/BF01731581, 7463489.