Defect in dolichol-dependent glycosylation increases sensitivity of Saccharomyces cerevisiae towards anti-fungal drugs

Yeast

Volumn 27, Issue 8, 2010, Pages 637-645

  Juchimiuk, Mateusz ^a   Pasikowska, Monika ^a   Zatorska, Ewa ^a   Laudy, Agnieszka E ^b   Smoleńska Sym, Gabriela ^c   Palamarczyk, Grazyna ^a  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

Author keywords

Antifungal drugs; Cell wall; Dolichol; Glycosylation; Saccharomyces cerevisiae

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CASPOFUNGIN; DIMETHYLALLYLTRANSFERASE; DOLICHOL; DOLICHOL KINASE; DOLICHOL PHOSPHATE MANNOSE; DOLICHOL PHOSPHATE MANNOSE SYNTHASE; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; PHOSPHOTRANSFERASE; SYNTHETASE; UNCLASSIFIED DRUG;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CELL WALL; CONTROLLED STUDY; FUNGAL CELL; FUNGUS MUTANT; HEAT SENSITIVITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; RER2 GENE; SACCHAROMYCES CEREVISIAE;

ANTIFUNGAL AGENTS; CELL WALL; DIMETHYLALLYLTRANSTRANSFERASE; DOLICHOL; GENE EXPRESSION; GLYCOPROTEINS; GLYCOSYLATION; HOT TEMPERATURE; MANNOSYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 77956794278     PISSN: 0749503X     EISSN: 10970061     Source Type: Journal    
DOI: 10.1002/yea.1803     Document Type: Article

References (17)

1. Bickle M, Delley PA, Schmidt A, Hall MN. 1998. Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17: 2235-2245.
2. Dallies N, Francois J, Paquet V. 1998. A new method for quantitative determination of polysaccharides in the yeast cell wall. Application to the cell wall defective mutants of Saccharomyces cerevisiae. Yeast 14: 1297-1306.
3. Deresinski SC, Stevens DA. 2003. Caspofungin. Clin Infect Dis 36: 1445-1457.
4. Dodds C, Miller AL, Rose CR. 1960. Blood pyruvate and lactate response of normal subjects to dextrose, sucrose, and liquid glucose. Lancet. 2: 178-180.
5. Gallis HA, Drew RH, Pickard WW. 1990. Amphotericin B: 30 years of clinical experience. Rev Infect Dis 12: 308-329.
6. Groll AH, Walsh TJ. 2001. Caspofungin: Pharmacology, safety and therapeutic potential in superficial and invasive fungal infections. Expert Opin Investig Drugs 10: 1545-1558.
7. Heller L, Orlean P, Adair WL Jr. 1992. Saccharomyces cerevisiae sec59 cells are deficient in dolichol kinase activity. Proc Natl Acad Sci USA 89: 7013-7016.
8. Kotler-Brajtburg J, Price HD, Medoff G, Schlesinger D, et al. 1974. The molecular basis for the selective toxicity of amphotericin B for yeast and filipin for animal oils. Antimicrob Agents Chemother 5: 377-382.
9. Levin D. 1993. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol 13: 3067-3075.
10. Lommel M, Bagnat M, Strahl S. 2004. Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants. Mol Cell Biol 24: 46-57.
11. Lyman CA, Walsh TJ. 1992. Systemically administered antifungal agents. A review of their clinical pharmacology and therapeutic applications. Drugs 44: 9-35.
12. Orlean P. 1992. Enzymes that recognize dolichols participate in three glycosylation pathways and are required for protein secretion. Biochem Cell Biol 70: 438-447.
13. Orlowski J, Machula K, Janik A, et al. 2007. Dissecting the role of dolichol in cell wall assembly in the yeast mutants impaired in early glycosylation reactions. Yeast 24: 239-252.
14. Perlińska-Lenart U, Bańkowska R, Palamarczyk G, Kruszewska JS. 2006. Overexpression of the Saccharomyces cerevisiae RER2 gene in Trichoderma reesei affects dolichol dependent enzymes and protein glycosylation. Fungal Genet Biol 43: 422-429.
15. Ram AF, Kapteyn JC, Montijn RC, et al. 1998. Loss of the plasma membrane-bound protein Gas1p in Saccharomyces cerevisiae results in the release of 1,3-glucan into the medium and induces a compensation mechanism to ensure cell wall integrity. J Bacteriol 180: 1418-1424.
16. Reissig JL, Strominger JL, Leloir LF. 1955. A modified colorimetric method for the estimation of N-acetylamino sugars. J Biol Chem 217: 959-966.
17. Strahl-Bolsinger S, Immervoll T, Deutzmann R, Tanner W. 1993. PMT1, the gene for a key enzyme of protein O-glycosylation in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1993; 90: 8164-8168.