Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset

Rheumatology International

Volumn 32, Issue 10, 2012, Pages 3097-3102

  Rodríguez Rodríguez, Luis ^a   Lamas, José Ramón ^a   Varadé, Jezabel ^a   Tornero Esteban, Pilar ^a   Abasolo, Lydia ^a   De La Concha, Emilio Gomez ^a   Jover, Juan Angel ^a   Urcelay, Elena ^a   Fernández Gutiérrez, Benjamín ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

Author keywords

Age at disease onset; Educational level; PTPN22; Rheumatoid arthritis; Shared epitope; STAT4

Indexed keywords

NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; STAT4 PROTEIN;

ALLELE; ARTICLE; EDUCATION; ENVIRONMENTAL FACTOR; GENOTYPE; HEREDITY; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGE OF ONSET; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CHILD; EDUCATIONAL STATUS; ENVIRONMENT; EPITOPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HLA-DRB1 CHAINS; HUMANS; LINEAR MODELS; MALE; PEPTIDES, CYCLIC; POLYMORPHISM, GENETIC; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; RISK ASSESSMENT; RISK FACTORS; SPAIN; STAT4 TRANSCRIPTION FACTOR;

EID: 84867897466     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-011-2090-9     Document Type: Article

References (36)

1. Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356-361
2. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K et al (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43:30-37
3. Imboden JB (2009) The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol 4:417-434
4. Newton JL, Harney SM, Wordsworth BP, Brown MA (2004) A review of the MHC genetics of rheumatoid arthritis. Genes Immun 5:151-157
5. MacKay K, Eyre S, Myerscough A, Milicic A, Barton A, Laval S et al (2002) Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. Arthritis Rheum 46:632-639
6. MacGregor A, Ollier W, Thomson W, Jawaheer D, Silman A (1995) HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity. J Rheumatol 22:1032-1036
7. Hellier J, Eliaou J, Daures J, Sany J, Combe B (2001) HLA-DRB1 genes and patients with late onset rheumatoid artritis. Ann Rheum Dis 60:531-533
8. Wu H, Khanna D, Park G, Gersuk V, Nepom GT, Wong WK, Paulus HE, Tsao BP (2004) Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort. Arthritis Rheum 50:3093-3103
9. Stavropoulos C, Spyropoulou M, Koumantaki Y, Kappou I, Kaklamanis PV, Linos A, Giziaki E, Kaklamani E (1997) HLA-DRB1*genotypes in Greek rheumatoid arthritis patients: association with disease characteristics, sex and age at onset. Br J Rheumatol 36:141-142
10. The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 447:661-678
11. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK et al (2007) The PTPN22 C1858T functional polymorphism and autoimmune diseases-A meta-analysis. Rheumatology (Oxford) 46:49-56
12. Steer S, Lad B, Grumley JA, Kingsley GH, Fisher SA (2005) Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect. Arthritis Rheum 52:358-360
13. Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93:2013-2024
14. Cloutier JF, Veillette A (1999) Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 189:111-121
15. Kokkonen H, Johansson M, Innala L, Jidell E, Rantapää-Dahlqvist S (2007) The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden. Arthritis Res Ther 9:R56
16. Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW et al (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 357:977-986
17. Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J et al (2008) Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 17:2274-2279
18. Horvath CM (2000) STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 25:496-502
19. Korman BD, Kastner DL, Gregersen PK, Remmers EF (2008) STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep 8:398-403
20. Walker JG, Ahern MJ, Coleman M, Weedon H, Papangelis V, Beroukas D et al (2006) Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 65:149-156
21. Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK (2007) Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 13:455-460
22. Kastbom A, Strandberg G, Lindroos A, Skogh T (2004) Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). Ann Rheum Dis 63:1085-1089
23. Varadé J, Loza-Santamaría E, Fernández-Arquero M, Lamas JR, de Los Angeles Figueredo M, Jover JA et al (2009) Shared epitope and anti-cyclic citrullinated peptide antibodies: relationship with age at onset and duration of disease in rheumatoid arthritis. J Rheumatol 36:1085-1086
24. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Toes RE, Huizinga TW (2005) Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis. Arthritis Res Ther 7:R949
25. Pedersen M, Jacobsen S, Klarlund M, Frisch M (2006) Socioeconomic status and risk of rheumatoid arthritis: a Danish case-control study. J Rheumatol 33:1069-1074
26. Bengtsson C, Nordmark B, Klareskog L, Lundberg I, Alfredsson L, EIRA Study Group (2005) Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study. Ann Rheum Dis 64:1588-1594
27. Pincus T (2007) Patient questionnaires and formal education as more significant prognostic markers than radiographs or laboratory tests for rheumatoid arthritis mortality-limitations of a biomedical model to predict long-term outcomes. Bull NYU Hosp Jt Dis 65(Suppl 1):S29-S36
28. Pincus T, Keysor J, Sokka T, Krishnan E, Callahan LF (2004) Patient questionnaires and formal education level as prospective predictors of mortality over 10 years in 97% of 1416 patients with rheumatoid arthritis from 15 United States private practices. J Rheumatol 31:229-234
29. Vliet Vlieland TP, Buitenhuis NA, van Zeben D, Vandenbroucke JP, Breedveld FC, Hazes JM (1994) Sociodemographic factors and the outcome of rheumatoid arthritis in young women. Ann Rheum Dis 53:803-806
30. Gonzalez-Gay MA, Garcia-Porrua C, Hajeer AH (2002) Influence of human leukocyte antigen-DRB1 on the susceptibility and severity of rheumatoid arthritis. Semin Arthritis Rheum 31:355-360
31. Hajeer AH, Dababneh A, Makki RF, Thomson W, Poulton K, González-Gay MA et al (2000) Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients. Tissue Antigens 55:319-325
32. Gonzalez-Gay MA, Hajeer AH, Dababneh A, Makki R, Garcia-Porrua C, Thomson W et al (2001) Seronegative rheumatoid arthritis in elderly and polymyalgia rheumatica have similar patterns of HLA association. J Rheumatol 28:122-125
33. González-Gay MA, Amoli MM, Garcia-Porrua C, Ollier WE (2003) Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica. Semin Arthritis Rheum 33:38-48
34. Bach JF (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347:911-920
35. Inman RD (1991) Infectious etiology of rheumatoid arthritis. Rheum Dis Clin North Am 17:859-870
36. Toussirot E, Roudier J (2008) Epstein-Barr virus in autoimmune diseases. Best Pract Res Clin Rheumatol 22:883-896