Is the expression of Transforming Growth Factor-Beta1 after fracture of long bones solely influenced by the healing process?

International Orthopaedics

Volumn 36, Issue 10, 2012, Pages 2173-2179

  Kaiser, Georg ^a   Thomas, Anita ^a   Köttstorfer, Julia ^a   Kecht, Mathias ^a   Sarahrudi, Kambiz ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ALCOHOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FRACTURE HEALING; HUMAN; LONG BONE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELIABILITY; RETROSPECTIVE STUDY; SEX DIFFERENCE; SMOKING;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALCOHOLISM; DIABETES MELLITUS; FEMALE; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEX FACTORS; SMOKING; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84867892888     PISSN: 03412695     EISSN: 14325195     Source Type: Journal    
DOI: 10.1007/s00264-012-1575-9     Document Type: Conference Paper

References (55)

1. Lissenberg-Thunnissen SN, de Gorter DJ, Sier CF, Schipper IB (2011) Use and efficacy of bone morphogenetic proteins in fracture healing. Int Orthop 35:1271-1280
2. Pecina M, Haspl M, Jelic M, Vukicevic S (2003) Repair of a resistant tibial non-union with a recombinant bone morphogenetic protein-7 (rh-BMP-7). Int Orthop 27:320-321
3. Pećina M, Giultaij LR, Vukičević S (2001) Orthopaedic applications of osteogenic protein-1 (BMP-7). Int Orthop 25:203-208
4. Ong CT, Choon DS, Cabrera NP et al (2002) The treatment of open tibial fractures and of tibial non-union with a novel external fixator. Injury 33:829-834
5. Gustilo RB, Mendoza RM, Williams DN (1984) Problems in the management of type III (severe) open fracture: a new classification of type III open fractures. J Trauma 24:742-746
6. Warren SB, Brooker AF (1992) Intramedullary nailing of tibial nonunion. Clin Orthop 285:236-243
7. Wu CC, Shih CH (1992) Treatment of 84 cases of femoral nonunion. Acta Orthop Scand 63:57-60
8. Sarahrudi K, Thomas A, Mousavi M et al (2011) Elevated transforming growth factor-beta 1(TGF-B1) levels in human fracture healing. Injury 42:833-837
9. Sarahrudi K, Mousavi M, Thomas A et al (2010) Elevated levels of macrophage colony stimulating factor in human fracture healing. J Orthop Res 28(5):671-676
10. Sarahrudi K, Thomas A, Braunsteiner T et al (2009) VEGF serum concentrations in patients with long bone fractures: a comparison between impaired and normal fracture healing. J Orthop Res 27(10):1293-1297
11. Zimmermann G, Henle P, Kusswetter M et al (2005) TGF-beta 1 as a marker of delayed fracture healing. Bone 36:779-785
12. Giannoudis P, Psarakis S, Kontakis G (2007) Can we accelerate fracture healing? A critical analysis of the literature. Injury 38(1):81-89
13. Giorgetti AP, César Neto JB, Ruiz KG et al (2010) Cigarette smoke inhalation modulates gene expression in sites of bone healing: a study in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(4):447-452
14. Bostrom MP (1998) Expression of bone morphogenetic proteins in fracture healing. Clin Orthop 355:116-123
15. Gazit D, Zilberman Y, Turgeman G et al (1999) Recombinant TGF-beta 1 stimulates bone marrow osteoprogenitor cell activity and bone matrix synthesis in osteopenic, old male mice. J Cell Biochem 73:379-389
16. Yuhara S, Kasagi S, Inoue A et al (1999) Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol 383:387-393
17. Harley BJ, Beaupre LA, Jones CA et al (2002) The effect of time to definitive treatment on the rate of non-union and infection in open fractures. J Orthop Trauma 16:484-490
18. Moghaddam A, Weiss S, Wölfl CG et al (2010) Cigarette smoking decreases TGF-β1 serum concentrations after long bone fracture. Injury 41(19):1020-1025
19. Ma L, Zheng LW, Sham MH et al (2011) Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing. J Oral Maxillofac Surg 69(1):28-35
20. Ma L, Zwahlen RA, Zheng LW et al (2011) Influence of nicotine on the biological activity of rabbit osteoblasts. Clin Oral Impl Res 22(3):338-342
21. Gullihorn L, Karpman R, Lippiello L (2005) Differential effects of nicotine and smoke condensate on bone cell metabolic activity. J Orthop Trauma 19:17-22
22. Skott M, Andreassen TT, Ulrich-Vinther M et al (2006) Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats. J Orthop Res 24:1472-1479
23. Preira ML, Carvalho JC, Peres A et al (2010) Simultaneous effects of nicotine, acrolein, and acetaldehyde on osteogenic-induced bone marrow cells cultured on plasma-sprayed titanium implants. Int J Oral Maxillofac Implants 25:112-122
24. Parker MJ, Raghavan R, Gurusamy K (2007) Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res 458:175-179
25. Chang MA, Bishop AT, Moran SL et al (2006) The outcomes and complications of 1,2-intercompartmental supraretinacular artery pedicled vascularized bone grafting A of scaphoid nonunions. J Hand Surg Am 31:387-396
26. Li Z, Zhang W, Li ZB et al (2006) Abnormal union of mandibular fractures: a review of 84 cases. J Oral Maxillofac Surg 64:1225-1231
27. David V, Lafage-Proust MH, Laroche N et al (2006) Two week longitudinal survey of bone architecture alteration in the hindlimb unloaded A rat model of bone loss: sex differences. Am J Physiol Endocrinol Metab 290:440-447
28. Muschler GF, Nitto H, Boehm CA et al (2001) Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J Orthop Res 19:117-125
29. Benz DJ, Haussler MR, Thomas MA et al (1991) High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. Endocrinology 128(6):2723-2730
30. Strube P, Mehta M, Baerenwaldt A et al (2009) Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity. Bone 45:1065-1072
31. Nicolas V, Prewett A, Bettica P et al (1994) Age related decrease in insulin-like growth factor and transforming growth factor-β in femoral cortical bone from both men and women: implication for bone loss with aging. J Clin Endocrinol Metab 78:1011-1016
32. Aho AJ (1966) Electron microscopic and histologic studies on fracture repair in old and young rats. Acta Chir Scand Suppl 357:162-165
33. Meyer RA Jr, Tsahakis PJ, Martin DF et al (2001) Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res 19:428-435
34. Meyer RA Jr, Meyer MH, Tenholder M et al (2003) Gene expression in older rats with delayed union of femoral fractures. J Bone Joint Surg Am 85:1243-1254
35. Lu C, Miclau T, Hu D et al (2005) Cellular basis for age-related changes in fracture repair. J Orthop Res 23:1300-1307
36. Street JT, Wang JH, Wu QD et al (2001) The angiogenic response to skeletal injury is preserved in the elderly. J Orthop Res 19:1057-1066
37. Parker MJ (1994) Prediction of fracture union after internal fixation of intracapsular femoral neck fractures. Injury 25(2):3-6
38. Robinson CM, Court-Brown CM, McQueen MM et al (2004) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture. J Bone Joint Surg Am 86:1359-1365
39. Macey LR, Kana SM, Jingushi S et al (1989) Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 71:722-733
40. Beam HA, Parsons JR, Lin SS (2002) The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 20:1210-1216
41. Funk JR, Hale JE, Carmines D et al (2000) Biomechanical evaluation of early fracture healing in normal and diabetic rats. J Orthop Res 18:126-132
42. Herbsman H, Powers JC, Hirschman A et al (1968) Retardation of fracture healing in experimental diabetes. J Surg Res 8:424-431
43. Cozen L (1972) Does diabetes delay fracture healing? Clin Orthop 82:134-140
44. Levin ME, Boisseau VC, Avioli LV (1976) Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes. N Engl J Med 294:241-245
45. Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop 232:210-216
46. Tyndall WA, Beam HA, Zarro C et al (2003) Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop 408:319-330
47. Gandhi A, Doumas C, O'Connor JP et al (2006) The effects of local platelet rich plasma delivery on diabetic fracture healing. Bone 38:540-546
48. Manus RC Jr, Dodson TB, Miller EJ Jr et al (2000) Nutritional status on substance abusers with mandible fractures. J Oral Maxillofac Surg 58:153
49. Serena-Gómez E, Passeri LA (2008) Complications of mandible fractures related to substance abuse. J Oral Maxillofac Surg 66(10):2028-2034
50. Santolaria F, Pérez-Manzano JL, Milena A et al (2000) Nutritional assessment in alcoholic patients. Its relationship with alcoholic intake, feeding habits, organic complications and social problems. Drug Alcohol Depend 59:295
51. Sandler NA (2001) Patients who abuse drugs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:12
52. Klein RF (1997) Alcohol-induced bone disease: impact of ethanol on osteoblast proliferation. Alcohol Clin Exp Res 21:392-399
53. Nyquist F, Karlsson MK, Obrant KJ et al (1997) Osteopenia in alcoholics after tibia shaft fractures. Alcohol 32:599-604
54. Chavassieux PS, Serre CM, Vernaud P et al (1993) In vitro evaluation of dose-dependant effect of ethanol on human osteoblastic cells. Bone Miner 22:95-103
55. Dyer SA, Buckendahl P, Sampson HW (1998) Alcohol consumption inhibits osteoblastic cell proliferation and activity in vivo. Alcohol 16:337-341