Sex-specific compromised bone healing in female rats might be associated with a decrease in mesenchymal stem cell quantity

Bone

Volumn 45, Issue 6, 2009, Pages 1065-1072

  Strube, Patrick ^a   Mehta, Manav ^a   Baerenwaldt, Anne ^a   Trippens, Jessica ^a   Wilson, Cameron J ^a   Ode, Andrea ^a   Perka, Carsten ^a   Duda, Georg N ^a   Kasper, Grit ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Bone defect; Bone healing; Gender; MSCs; Sex

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DEFECT; BONE MINERALIZATION; BONE REGENERATION; CALLUS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; EXTERNAL FIXATOR; FEMALE; FEMUR OSTEOTOMY; FRACTURE HEALING; HIP RADIOGRAPHY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; RAT; SEX DIFFERENCE;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONY CALLUS; CELL COUNT; COLONY-FORMING UNITS ASSAY; FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; WOUND HEALING; X-RAY MICROTOMOGRAPHY;

EID: 70350215894     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.08.005     Document Type: Article

References (37)

1. Haas N.P. Callus modulation-fiction or reality?. Chirurg 71 (2000) 987-988
2. Parker M.J., Raghavan R., and Gurusamy K. Incidence of fracture-healing complications after femoral neck fractures. Clin. Orthop. Relat. Res. 458 (2007) 175-179
3. Chang M.A., Bishop A.T., Moran S.L., and Shin A.Y. The outcomes and complications of 1,2-intercompartmental supraretinacular artery pedicled vascularized bone grafting of scaphoid nonunions. J. Hand Surg. [Am] 31 (2006) 387-396
4. Li Z., Zhang W., Li Z.B., and Li J.R. Abnormal union of mandibular fractures: a review of 84 cases. J. Oral Maxillofac. Surg. 64 (2006) 1225-1231
5. David V., Lafage-Proust M.H., Laroche N., Christian A., Ruegsegger P., and Vico L. Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E440-E447
6. Lill C.A., Hesseln J., Schlegel U., Eckhardt C., Goldhahn J., and Schneider E. Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J. Orthop. Res. 21 (2003) 836-842
7. Meyer R.A., Meyer M.H., Phieffer L.S., and Banks D.M. Delayed union of femoral fractures in older rats: decreased gene expression. BMC Musculoskelet. Disord. 2 (2001) 2
8. Strube P., Sentuerk U., Riha T., Kaspar K., Mueller M., Kasper G., et al. Influence of age and mechanical stability on bone defect healing: age reverses mechanical effects. Bone 42 (2008) 758-764
9. Ejiri S., Tanaka M., Watanabe N., Anwar R.B., Yamashita E., Yamada K., et al. Estrogen deficiency and its effect on the jaw bones. J. Bone Miner. Metab. 26 (2008) 409-415
10. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
11. Petite H., Viateau V., Bensaid W., Meunier A., de Pollak C., Bourguignon M., et al. Tissue-engineered bone regeneration. Nat. Biotechnol. 18 (2000) 959-963
12. Kasper G., Glaeser J.D., Geissler S., Ode A., Tuischer J., Matziolis G., et al. Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior. Stem Cells 25 (2007) 1985-1994
13. Kasper G., Dankert N., Tuischer J., Hoeft M., Gaber T., Glaeser J.D., et al. Mesenchymal stem cells regulate angiogenesis according to their mechanical environment. Stem Cells 25 (2007) 903-910
14. da Silva Meirelles L., Caplan A.I., and Nardi N.B. In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26 (2008) 2287-2299
15. Kaspar K., Matziolis G., Strube P., Senturk U., Dormann S., Bail H.J., et al. A new animal model for bone atrophic nonunion: fixation by external fixator. J. Orthop. Res. 26 (2008) 1649-1655
16. Strube P., Mehta M., Putzier M., Matziolis G., Perka C., and Duda G.N. A new device to control mechanical environment in bone defect healing in rats. J. Biomech. 41 (2008) 2696-2702
17. Schmidmaier G., Wildemann B., Melis B., Krummrey G., Einhorn T.A., Haas N.P., et al. Development and characterization of a standard closed tibial fracture model in the rat. Eur. J. Trauma 30 (2004) 35-42
18. White III A.A., Panjabi M.M., and Southwick W.O. The four biomechanical stages of fracture repair. J. Bone Joint Surg. Am. 59 (1977) 188-192
19. Dobson K.R., Reading L., Haberey M., Marine X., and Scutt A. Centrifugal isolation of bone marrow from bone: an improved method for the recovery and quantitation of bone marrow osteoprogenitor cells from rat tibiae and femurae. Calcif. Tissue Int. 65 (1999) 411-413
20. Kasper G., Mao L., Geissler S., Draycheva A., Trippens J., Kühnisch J., et al. Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells 27 6 (2009 Jun) 1288-1297
21. Claes L.E., Heigele C.A., Neidlinger-Wilke C., Kaspar D., Seidl W., Margevicius K.J., et al. Effects of mechanical factors on the fracture healing process. Clin. Orthop. Relat. Res. (1998) S132-S147
22. Einhorn T.A., Lane J.M., Burstein A.H., Kopman C.R., and Vigorita V.J. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg. Am. 66 (1984) 274-279
23. Harrison L.J., Cunningham J.L., Stromberg L., and Goodship A.E. Controlled induction of a pseudarthrosis: a study using a rodent model. J. Orthop. Trauma 17 (2003) 11-21
24. Mark H., Bergholm J., Nilsson A., Rydevik B., and Stromberg L. An external fixation method and device to study fracture healing in rats. Acta Orthop. Scand. 74 (2003) 476-482
25. Mark H., and Rydevik B. Torsional stiffness in healing fractures: influence of ossification: an experimental study in rats. Acta Orthop. 76 (2005) 428-433
26. Currey J. Measurement of the mechanical properties of bone: a recent history. Clin. Orthop. Relat. Res. 467 8 (2009 Aug) 1948-1954
27. Pien D.M., Olmedo D.G., and Guglielmotti M.B. Influence of age and gender on peri-implant osteogenesis. Age and gender on peri-implant osteogenesis. Acta Odontol. Latinoam. 14 (2001) 9-13
28. Meyer M.H., and Meyer Jr. R.A. Genes with greater up-regulation in the fracture callus of older rats with delayed healing. J. Orthop. Res. 25 (2007) 488-494
29. Meyer Jr. R.A., Tsahakis P.J., Martin D.F., Banks D.M., Harrow M.E., and Kiebzak G.M. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J. Orthop. Res. 19 (2001) 428-435
30. Muschler G.F., Nitto H., Boehm C.A., and Easley K.A. Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J. Orthop. Res. 19 (2001) 117-125
31. Naik A.A., Xie C., Zuscik M.J., Kingsley P., Schwarz E.M., Awad H., et al. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J. Bone Miner. Res. 24 (2009) 251-264
32. Shamsul B.S., Aminuddin B.S., Ng M.H., and Ruszymah B.H. Age and gender effect on the growth of bone marrow stromal cells in vitro. Med. J. Malaysia 59 (2004) 196-197
33. Siddappa R., Licht R., van Blitterswijk C., and de Boer J. Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering. J. Orthop. Res. 25 (2007) 1029-1041
34. Fleming Jr. J.E., Cornell C.N., and Muschler G.F. Bone cells and matrices in orthopedic tissue engineering. Orthop. Clin. North Am. 31 (2000) 357-374
35. Ludwig S.C., and Boden S.D. Osteoinductive bone graft substitutes for spinal fusion: a basic science summary. Orthop. Clin. North Am. 30 (1999) 635-645
36. Quarto R., Thomas D., and Liang C.T. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif. Tissue Int. 56 (1995) 123-129
37. Hernigou P., Poignard A., Beaujean F., and Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J. Bone Joint Surg. Am. 87 (2005) 1430-1437