VEGF serum concentrations in patients with long bone fractures: A comparison between impaired and normal fracture healing

Journal of Orthopaedic Research

Volumn 27, Issue 10, 2009, Pages 1293-1297

  Sarahrudi, Kambiz ^a   Thomas, Anita ^a   Braunsteiner, Tomas ^a   Wolf, Harald ^a   Vécsei, Vilmos ^a   Aharinejad, Seyedhossein ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bone; Delayed nonunion; Fracture; Growth factors; VEGF

Indexed keywords

GROWTH FACTOR; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BONE PLATE; BONE SCREW; CALLUS; CONTROLLED STUDY; FEMALE; FEMUR FRACTURE; FIBULA FRACTURE; FOREARM FRACTURE; FRACTURE; FRACTURE EXTERNAL FIXATION; FRACTURE FIXATION; FRACTURE HEALING; FRACTURE NONUNION; FRACTURE TREATMENT; HUMAN; HUMERUS FRACTURE; INTRAMEDULLARY NAILING; LONG BONE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TIBIA FRACTURE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FEMORAL FRACTURES; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; HUMERAL FRACTURES; MALE; MIDDLE AGED; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70349194534     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20906     Document Type: Article

References (27)

1. Cruess RL, Dumont J. 1975. Fracture healing. Can J Surg 18:403-413.
2. Gerstenfeld LC, Cullinane DM, Barnes GL, et al. 2003. Fracture healing as post-natal development process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88:373-384.
3. Joyce ME, Roberts AB, Sporn MB, et al. 1990. Transforming Growth factor-beta and initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 21:199-209.
4. Nunamaker DM. 1998. Experimental models of fracture repair. Clin Orthop Relat Res 355S:56-65.
5. Bennett NT, Schultz GS. 1993. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am J Surg 166:74-81. (Pubitemid 23281429)
6. Kiristy CP, Lynch AB, Lynch SE. 1993. Role of growth factors in cutaneous wound healing: a review. Crit Rev Oral Biol Med 4:729-760.
7. Martin P, Hopkinson-Woolley J, McCluskey J. 1992. Growth factors and cutaneous wound repair. Prog Growth Factor Res 4:25-44.
8. Deckers MM, van Bezooijen RL, van der Horst G, et al. 2002. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143:1545-1553. (Pubitemid 34274386)
9. Kleinheinz J, Wiesmann HP, Stratmann U, et al. 2002. Evaluating angiogenesis and osteogenesis modified by vascular endothelial growth factor (VEGF). Mund Kiefer Gesichtschir 6:175-182. (in German). (Pubitemid 34535996)
10. Street J, Bao M, deGuzman L, et al. 2002. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99:9656-9661.
11. Eckardt H, Ding M, Lind M, et al. 2005. Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model. J Bone Joint Surg [Br] 87-B:1434-1438. (Pubitemid 41511813)
12. Midy V, Plouet J. 1994. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem Biophys Res Commun 199:380-386. (Pubitemid 24179960)
13. Bab I, Gazit D, Muhlrad A, et al. 1988. Regenerating bone marrow produces a potent growth-promoting activity to osteogenic cells. Endocrinology 123:345-352. (Pubitemid 18176989)
14. Einhorn TA, Simon G, Devlin VJ, et al. 1990. The osteogenic response to distant skeletal injury. Bone Joint Surg Am 72:1374-1378.
15. Gazit D, Karmish M, Holzman L, et al. 1990. Regenerating marrow induces systemic increase in osteo- and chondrogenesis. Endocrinology 126:2607-2613. (Pubitemid 20173054)
16. Groeneveld EH, Burger EH. 2000. Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol 142:9-21. (Pubitemid 30094193)
17. Manolagas SC, Jilka RL. 1995. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
18. Xu SW, Yu R, Zhao GF, et al. 2003. Early period of fracture healing in ovariectomized rats. Chin J Traumatol 6:160-166.
19. Lammens J, Liu Z, Aerssens J, et al. 1998. Distraction bone healing versus osteotomy healing: a comparative biochemical analysis. J Bone Miner Res 13:279-286. (Pubitemid 28082385)
20. Zimmermann G, Henle P, Küsswetter M, et al. 2005. TGF-b1 as marker of delayed fracture healing. Bone 36:779-785. (Pubitemid 40616012)
21. Streeten EA, Brandi ML. 1990. Biology of bone endothelial cells. Bone Miner 10:85-94.
22. Geiger F, Bertram H, Berger I, et al. 2005. Vascular endothelial growth factor gene-activated matrix (VEGF165- GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 20:2028-2035. (Pubitemid 41532788)
23. Tarkka T, Sipola A, Jamsa T, et al. 2003. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med 5:560-566. (Pubitemid 40310399)
24. Weiss S, Zimmermann G, Baumgart R, et al. 2005. Systemic regulation of angiogenesis and matrix degradation in bone regeneration - Distraction osteogenesis compared to rigid fracture healing. Bone 37:781-790. (Pubitemid 41773488)
25. Weiss S, Zimmermann G, Pufe T, et al. 2008. The systemic angiogenic response during bone healing. Arch Orthop Trauma Surg 27: (Epub ahead of print).
26. Street JT, Wang JH, Wu QD, et al. 2001. The angiogenic response to skeletal injury is preserved in the elderly. J Orthop Res 19:1057-1066. (Pubitemid 33150182)
27. Grad S, Ertel W, Keel M, et al. 1998. Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn. Clin Chem Lab Med 36:379-383. (Pubitemid 28379046)