G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nude mice

Tohoku Journal of Experimental Medicine

Volumn 228, Issue 2, 2012, Pages 147-156

  Liu, Xin ^a   Peng, Jing ^a   Sun, Wenchang ^a   Yang, Shufeng ^a   Deng, Guoying ^a   Li, Fang ^a   Cheng, Jya Wei ^b   Gordon, John R ^c  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

Chemokine; CXCR1; CXCR2; G31P; Prostate cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CXCL8 CHEMOKINE (3-72) LYSINE 11 ARGININE GLYCINE 31 PROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLOOD VESSEL PARAMETERS; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CELL ASSAY; CELL GROWTH; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; FLUORESCENCE IMAGING; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVESSEL DENSITY; MOUSE; NONHUMAN; NUDE MOUSE; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; WOUND HEALING;

ANIMALS; ANTIGENS, CD31; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-8; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PEPTIDE FRAGMENTS; PROSTATIC NEOPLASMS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867886828     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.228.147     Document Type: Article

References (46)

1. Araki, S., Omori, Y., Lyn, D., Singh, R.K., Meinbach, D.M., Sandman, Y., Lokeshwar, V.B. & Lokeshwar, B.L. (2007) Interleukin-8 is a molecular determinant of androgen-independence and progression in prostate cancer. Cancer Res., 67, 6854-6862.
2. Bao, Z., Ye, Q., Gong, W., Xiang, Y. & Wan, H. (2010) Humanized monoclonal antibody against the chemokine CXCL-8 (IL-8) effectively prevents acute lung injury. Int. Immunopharmacol., 2, 259-263.
3. Bizzarri, C., Beccari, A.R., Bertini, R., Cavicchia, M.R., Giorgini, S. & Allegretti, M. (2006) ELR+ CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets. Pharmacol. Ther., 112, 139-149.
4. Bolitho, C., Hahn, M.A., Baxter, R.C. & Marsh, D.J. (2010) The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocr. Relat. Cancer, 4, 929-940.
5. Brat, D.J., Bellail, A.C. & Van Meir, E.G. (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro. Oncol., 2, 122-133.
6. Cerretti, D.P., Kozlosky, C.J., Vanden Bos, T., Nelson, N., Gearing, D.P. & Beckmann, M.P. (1993) Molecular characterization of receptors for human interleukin-8, GRO/melanoma growthstimulatory activity and neutrophil activating peptide-2. Mol. Immunol., 30, 359-367.
7. Charalambous, C., Pen, L.B., Su, Y.S., Milan, J., Chen, T.C. & Hofman, F.M. (2005) Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial. Cancer Res., 65, 10347-10354.
8. Csillik, B., Mihály, A., Krisztin-Péva, B., Chadaide, Z., Samsam, M., Knyihár-Csillik, E. & Fenyo, R. (2005) GABAergic parvalbumin-immunoreactive large calyciform presynaptic complexes in the reticular nucleus of the rat thalamus. J. Chem. Neuroanat., 30, 17-26.
9. Doll, D., Keller, L., Maak, M., Boulesteix, A.L., Siewert, J.R., Holzmann, B. & Janssen, K.P. (2010) Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int. J. Colorectal. Dis., 25, 573-581.
10. Gabellini, C., Trisciuoglio, D., Desideri, M., Candiloro, A., Ragazzoni, Y., Orlandi, A., Zupi, G. & Del Bufalo, D. (2009) Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression. Eur. J. Cancer, 45, 2618-2627.
11. Hinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C. & Strauss, M. (1999) NF-kappaB function in growth controlregulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol., 19, 2690-2698.
12. Holmes, W.E., Lee, J., Kuang, W.J., Rice, G.C. & Wood, W.I. (1991) Structure and functional expression of a human interleukin-8 receptor. Science, 253, 1278-1280.
13. Inoue, K., Slaton, J.W., Eve, B.Y., Kim, S.J., Perrotte, P., Balbay, M.D., Yano, S., Bar-Eli, M., Radinsky, R., Pettaway, C.A. & Dinney, C.P. (2000) Interleukin-8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer. Clin. Cancer Res., 6, 2104-2119.
14. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R.C., Ghafoor, A., Feuer, E.J. & Thun, M.J. (2005) Cancer statistics. CA. Cancer J. Clin., 55, 10-30.
15. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J. & Thun, M.J. (2007) Cancer statistics. CA. Cancer J. Clin., 57, 43-66.
16. John, A.E., Channon, K.M. & Greaves, D.R. (2005) Chemokines, Chemokine Receptors and Atherosclerosis. Curr. Top. Membr., 55, 223-253.
17. Kim, S.J., Uehara, H., Karashima, T., Mccarty, M., Shih, N. & Fidler, I.J. (2001) Expression of interleukin-8 correlates with angiogenesis, tumorigenicity and metastasis of human prostate cancer cells implanted orthotopically in nude mice. Neoplasia, 3, 33-42.
18. Kollmar, O., Junker, B., Rupertus, K., Menger, M.D. & Schilling, M.K. (2007) Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis. Eur. J. Surg. Oncol., 33, 803-811.
19. Lee, L.F., Louie, M.C. & Desai, S.J. (2004) Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene, 23, 2197-2205.
20. Li, A., Varney, M.L., Valasek, J., Godfrey, M., Dave, B.J. & Singh, R.K. (2005) Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis, 8, 63-71.
21. Li, F., Zhang, X. & Gordon, J.R. (2002a) CXCL8(3-73)K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL-8. Biochem. Biophys. Res. Commun., 293, 939-944.
22. Li, F., Zhang, X., Mizzi, C. & Gordon, J.R. (2002b) CXCL8(3-73) K11R/G31P antagonizes the neutrophil chemoattractants present in pasteurellosis and mastitis lesions and abrogates neutrophil influx into intradermal endotoxin challenge sites in vivo. Vet. Immunol. Immunopathol., 90, 65-77.
23. Luppi, F., Longo, A.M., de Boer, W.I., Rabe, K.F. & Hiemstra, P.S. (2007) Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation. Lung Cancer, 56, 25-33.
24. MacManus, C.F., Pettigrew, J., Seaton, A., Wilson, C., Maxwell, P.J., Berlingeri, S., Purcell, C., McGurk, M., Johnston, P.G. & Waugh, D.J. (2007) Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol. Cancer Res., 5, 737-748.
25. Maxwell, P.J., Gallagher, R., Seaton, A., Wilson, C., Scullin, P., Pettigrew, J., Stratford, I.J., Williams, K.J., Johnston, P.G. & Waugh, D.J. (2007) HIF-1 and NF-kB-mediated up-regulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells. Oncogene, 26, 7333-7345.
26. Mohapatra, S., Chu, B., Zhao, X., Djeu, J., Cheng, J.Q. & Pledger, W.J. (2009) Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. Int. J. Biochem. Cell Biol., 41, 595-602.
27. Murphy, C., McGurk, M., Pettigrew, J., Santinelli, A., Mazzucchelli, R., Johnston, P.G., Montironi, R. & Waugh, D.J. (2005) Nonapical and cytoplasmic expression of interleukin-8, CXCR1 and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer. Clin. Cancer Res., 11, 4117-4127.
28. Murphy, P.M. & Tiffany, H.L. (1991) Cloning of a complimentary DNA encoding a functional human interleukin-8 receptor. Science, 253, 1280-1283.
29. Nakabayashi, M., Werner, L., Oh, W.K., Regan, M.M., Kantoff, P.W. & Taplin, M.E. (2011) Secondary Hormonal Therapy in Men With Castration-Resistant Prostate Cancer. Clin. Genitourin. Cancer, 9, 95-103.
30. Nishiyama, T. (2012) Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer. J. Steroid. Biochem. Mol. Biol., 129, 179-190.
31. Patel, A., Miller, L., Ahmed, K. & Ondrey, F. (2004) NF-κ-B downregulation strategies in head and neck cancer treatment. Otolaryngol. Head Neck Surg., 131, 288-295.
32. Reiland, J., Furcht, L.T. & McCarthy, J.B. (1999) CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor. Prostate, 41, 78-88.
33. Shishodia, S. & Aggarwal, B.B. (2004) Nuclear factor-kB: a friend or a foe in cancer? Biochem. Pharmacol., 68, 1071-1080.
34. Shoji, S., Tang, X.Y., Umemura, S., Itoh, J., Takekoshi, S., Shima, M., Usui, Y., Nagata, Y., Uchida, T., Osamura, R.Y. & Terachi, T. (2009) Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. Eur. Urol., 55, 441-451.
35. Singh, S., Wu, S., Varney, M., Singh, A.P. & Singh, R.K. (2011) CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation. Microvasc. Res., 82, 318-325.
36. Stillie, R., Farooq, S.M., Gordon, J.R. & Stadnyk, A.W. (2009) The functional significance behind expressing two IL-8 receptor types on PMN. J. Leukoc. Biol., 86, 529-543.
37. Takami, M., Yerry, V. & Petruzzelli, L. (2002) Signaling pathways involved in CXCL8-dependent activation of adhesion through Mac-1. J. Immunol., 168, 4559-4566.
38. Tazzyman, S., Barry, S.T., Ashton, S., Wood, P., Blakey, D., Lewis, C.E. & Murdoch, C. (2011) Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth. Int. J. Cancer, 129, 847-858.
39. Varney, M.L., Singh, S., Li, A., Mayer-Ezell, R., Bond, R. & Singh, R.K. (2011) Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases. Cancer Lett., 300, 180-188.
40. Voboril, R., Hochwald, S.N., Li, J., Brank, A., Weberova, J., Wessels, F., Moldawer, L.L., Camp, E.R. & MacKay, S.L. (2004) Inhibition of NF-Kappa B augments sensitivity to 5-Fluorouracil/Folinic acid in colon cancer. J. Surg. Res., 120, 178-188.
41. Waugh, D.J. & Wilson, C. (2008) The Interleukin-8 Pathway in Cancer. Clin. Cancer Res., 14, 6735-6741.
42. Wilson, C., Wilson, T., Johnston, P.G., Longley, D.B. & Waugh, D.J. (2008) Interleukin-8 signaling attenuates TRAIL-and chemotherapy induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol. Cancer Ther., 7, 2649-2661.
43. Zhang, Y., Yu, G., Xiang, Y., Wu, J., Jiang, P., Lee, W. & Zhang, Y. (2010) Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing. Biochem. Biophys. Res. Commun., 398, 559-564.
44. Zhao, X., Town, J.R., Li, F., Zhang, X., Cockcroft, D.W. & Gordon, J.R. (2009) ELR-CXC Chemokine Receptor Antagonism Targets Inflammatory Responses at Multiple Levels. J. Immunol., 182, 3213-3222.
45. Zhao, X., Town, J.R., Zhang, X., Li, F., Li, W. & Gordon, J.R. (2010) Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth. Pulm. Pharmacol. Ther., 23, 22-28.
46. Zhu, W., He, S., Li, Y., Qiu, P., Shu, M., Ou, Y., Zhou, Y., Leng, T., Xie, J., Zheng, X., Xu, D., Su, X. & Yan, G. (2010) Antiangiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells. Vascul. Pharmacol., 52, 46-54.