Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth

Pulmonary Pharmacology and Therapeutics

Volumn 23, Issue 1, 2010, Pages 22-28

  Zhao, Xixing ^a   Town, Jennifer R ^a   Li, Fang ^b   Li, Wei ^b   Zhang, Xiaobei ^a   Gordon, John R ^a,c  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

Aspiration pneumonia; Bacterial clearance; Chemokine antagonist; ELR CXC chemokines; Neutrophil

Indexed keywords

ALPHA CHEMOKINE; ARGININE; CHEMOKINE RECEPTOR ANTAGONIST; GLUTAMIC ACID; INTERLEUKIN 8; LEUCINE; SODIUM CHLORIDE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPIRATION PNEUMONIA; BACTERIAL OVERGROWTH; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; GRAM NEGATIVE BACTERIUM; GUINEA PIG; HOSPITAL INFECTION; INFLAMMATION; INNATE IMMUNITY; LUNG LAVAGE; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PULMONARY VASCULAR DISEASE; STOMACH CONTENT;

ANIMALS; BACTERIA; CELL DEGRANULATION; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; FEMALE; GUINEA PIGS; IMMUNITY, INNATE; INTERLEUKIN-8; LUNG; NEUTROPHIL INFILTRATION; PNEUMONIA, ASPIRATION; RNA, MESSENGER;

EID: 74649086692     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2009.09.001     Document Type: Article

References (32)

1. Olsson G.L., Hallen B., and Hambraeus-Jonzon K. Aspiration during anaesthesia: a computer-aided study of 185,358 anaesthetics. Acta Anaesthesiol Scand 30 (1986) 84-92
2. Warner M.A., Warner M.E., and Weber J.G. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology 78 (1993) 56-62
3. Fowler A.A., Hamman R.F., Good J.T., Benson K.N., Baird M., Eberle D.J., et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med 98 (1983) 593-597
4. Pepe P.E., Potkin R.T., Reus D.H., Hudson L.D., and Carrico C.J. Clinical predictors of the adult respiratory distress syndrome. Am J Surg 144 (1982) 124-130
5. Marik P.E. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 344 (2001) 665-671
6. Beck-Schimmer B., Rosenberger D.S., Neff S.B., Jamnicki M., Suter D., Fuhrer T., et al. Pulmonary aspiration: new therapeutic approaches in the experimental model. Anesthesiology 103 (2005) 556-566
7. Folkesson H.G., Matthay M.A., Hebert C.A., and Broaddus V.C. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest 96 (1995) 107-116
8. Raghavendran K., Davidson B.A., Mullan B.A., Hutson A.D., Russo T.A., Manderscheid P.A., et al. Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1. Am J Physiol Lung Cell Mol Physiol 289 (2005) L134-L143
9. Baggiolini M. Chemokines and leukocyte traffic. Nature 392 (1998) 565-568
10. Rotta A.T., Shiley K.T., Davidson B.A., Helinski J.D., Russo T.A., and Knight P.R. Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance. Crit Care Med 32 (2004) 747-754
11. (3-74)K11R/G31P blocks neutrophil infiltration, pyrexia, and pulmonary vascular pathology in endotoxemic animals. J Leukoc Biol 78 (2005) 1265-1272
12. (3-73)K11R/G31P antagonizes ligand binding to the CXCR1 and CXCR2, and neutrophil responses to CXCL8/IL-8. Biochem Biophys Res Commun 293 (2002) 939-944
13. (3-73)K11R/G31P antagonizes the neutrophil chemoattractants present in pasteurellosis and mastitis lesions and abrogates neutrophil influx into intradermal endotoxin challenge sites in vivo. Vet Immunol Immunopathol 90 (2002) 65-77
14. ((3-74))K11R/G31P, effectively block ELR-CXC chemokine activity and airway endotoxemia pathology. Int Immunopharmacol 7 (2007) 1723-1731
15. Zhao X., Town J.R., Li F., Zhang X., Cockcroft D.W., and Gordon J.R. ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels. J Immunol 182 (2009) 3213-3222
16. Li F., and Gordon J.R. Il-8(3-73)K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun 286 (2001) 595-600
17. Davidson B.A., Knight P.R., Wang Z., Chess P.R., Holm B.A., Russo T.A., et al. Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol 288 (2005) L699-L708
18. Knight P.R., Davidson B.A., Nader N.D., Helinski J.D., Marschke C.J., Russo T.A., et al. Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration. Exp Lung Res 30 (2004) 535-557
19. (3-73)K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL-8. Biochem Biophys Res Commun 293 (2002) 939-944
20. Morisaki H., Aoyama Y., Shimada M., Ochiai R., and Takeda J. Leucocyte distribution during sevoflurane anaesthesia. Br J Anaesth 80 (1998) 502-503
21. Baba H., Nada T., Ohkusu K., Ezaki T., Hasegawa Y., and Paterson D.L. First case of bloodstream infection caused by Rhodococcus erythropolis. J Clin Microbiol (2009)
22. Rousseau A., Morcos M., Amrouche L., Fois E., Casetta A., Rio B., et al. Lethal pulmonary hemorrhage caused by a fulminant Stenotrophomonas maltophilia respiratory infection in an acute myeloid leukemia patient. Leuk Lymphoma 45 (2004) 1293-1296
23. Gruner E., Steigerwalt A.G., Hollis D.G., Weyant R.S., Weaver R.E., Moss C.W., et al. Human infections caused by Brevibacterium casei, formerly CDC groups B-1 and B-3. J Clin Microbiol 32 (1994) 1511-1518
24. Funke G., Falsen E., and Barreau C. Primary identification of Microbacterium spp. encountered in clinical specimens as CDC coryneform group A-4 and A-5 bacteria. J Clin Microbiol 33 (1995) 188-192
25. Ashitani J., Mukae H., Nakazato M., Ihi T., Mashimoto H., Kadota J., et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J 11 (1998) 104-111
26. Hiemstra P.S., van Wetering S., and Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur Respir J 12 (1998) 1200-1208
27. Standiford T.J., Kunkel S.L., Greenberger M.J., Laichalk L.L., and Strieter R.M. Expression and regulation of chemokines in bacterial pneumonia. J Leukoc Biol 59 (1996) 24-28
28. Yount N.Y., Waring A.J., Gank K.D., Welch W.H., Kupferwasser D., and Yeaman M.R. Structural correlates of antimicrobial efficacy in IL-8 and related human kinocidins. Biochim Biophys Acta 1768 (2007) 598-608
29. Cole A.M., Ganz T., Liese A.M., Burdick M.D., Liu L., and Strieter R.M. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol 167 (2001) 623-627
30. Exarhos N.D., Logan Jr. W.D., Abbott O.A., and Hatcher Jr. C.R. The importance of pH and volume in tracheobronchial aspiration. Dis Chest 47 (1965) 167-169
31. James C.F., Modell J.H., Gibbs C.P., Kuck E.J., and Ruiz B.C. Pulmonary aspiration-effects of volume and pH in the rat. Anesth Analg 63 (1984) 665-668
32. Lau D., and Baldus S. Myeloperoxidase and its contributory role in inflammatory vascular disease. Pharmacol Ther 111 (2006) 16-26