LDL oxidative modification and carotid atherosclerosis: Results of a multicenter study

Atherosclerosis

Volumn 225, Issue 1, 2012, Pages 231-236

  Nyyssonen K ^a   Kurl, S ^a   Karppi, J ^a   Nurmi, T ^a   Baldassarre, D ^b   Veglia, F ^c   Rauramaa, R ^a   de Faire, U ^d   Hamsten, A ^d   Smit, A J ^e   Mannarino, E ^f   Humphries, S E ^g   Giral, P ^h   Grossi, E ⁱ   Tremoli, E ^b,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF MILAN   (Italy)

^c CENTRO CARDIOLOGICO MONZINO   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f UNIVERSITY OF PERUGIA   (Italy)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

ⁱ Bracco Imaging SpA   (Italy)

Author keywords

Atherosclerosis; Conjugated dienes; Low density lipoprotein; Multicenter study; Oxidative modification

Indexed keywords

ALKADIENE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE DISTRIBUTION; AGED; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HIGH RISK PATIENT; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OXIDATION; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; ULTRASOUND; VIDEOTAPE;

AGED; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL, LDL; FEMALE; FINLAND; FRANCE; HUMANS; ITALY; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; NETHERLANDS; OXIDATION-REDUCTION; SWEDEN;

EID: 84867883733     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.08.030     Document Type: Article

References (30)

1. Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 2009, 50:S376-S381.
2. Itabe H. Oxidized low-density lipoproteins: what is understood and what remains to be clarified. Biol Pharm Bull 2003, 1:1-9.
3. Hevonoja T., Pentikäinen M.O., Hyvönen M.T., Kovanen P.E., Ala-Korpela M. Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. Biochim Biophys Acta 2000, 1488:189-210.
4. Ehara S., Ueda M., Naruko T., et al. Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation 2011, 103:1955-1960.
5. Weinbrenner T., Cladellas M., Covas M.I., et al. The SOLOS Study Investigators. high oxidative stress in patients with stable coronary heart disease. Atherosclerosis 2003, 168:99-106.
6. Karvonen J., Päivänsalo M., Kesäniemi Y.A., Hörkkö S. Immunoglobulin M type of autoantibodies to oxidized low-density lipoprotein has an inverse relation to carotid atherosclerosis. Circulation 2003, 108:2107-2112.
7. Naruko T., Ueda M., Ehara S., et al. Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict restenosis. Arterioscler Thromb Vasc Biol 2006, 26:877-883.
8. Ahotupa M., Ruutu M., Mäntylä E. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem 1996, 29:139-144.
9. Ahotupa M., Vasankari T.J. Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL. Free Radic Biol Med 1999, 27:1141-1150.
10. Toikka J., Laine H., Ahotupa M., et al. Increased arterial intima-media thickness in vivo LDL oxidation in young men with borderline hypertension. Hypertension 2000, 36:929-933.
11. Gavella M., Lipovac V., Car A., Vucic M. Baseline diene conjugation in LDL lipids from newly diagnosed type 2 diabetic patients. Diabete Metab 2002, 28:391-396.
12. Scheffer P.G., Henry R.M.A., Wever E.J.M., et al. LDL oxidative modifications in well- or moderately controlled type 2 diabetes. Diabetes Metab Res Rev 2004, 20:298-304.
13. Kals J., Kampus P., Kals M., et al. Impact of oxidative stress on arterial elasticity in patients with atherosclerosis. Am J Hypertens 2006, 19:902-908.
14. Baldassarre D., Nyyssönen K., Rauramaa R., et al. Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study. Eur Heart J 2010, 31:614-622.
15. Karppi J., Nurmi T., Kurl S., Rissanen T.H., Nyyssönen K. Lycopene, lutein and β-carotene as determinants of LDL conjugated dienes in serum. Atherosclerosis 2010, 209:565-572.
16. Hamed S.A., Hamed E.A., Hamdy R., Nabeshima T. Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy. Epilepsy Res 2007, 74:183-192.
17. Grewal J., Anand S., Islam S., Lonn E. SHARE and SHARE-AP Investigators. Prevalence and predictors of subclinical atherosclerosis among symptomatic " low risk" individuals in a multiethnic population. Atherosclerosis 2008, 197:435-442.
18. Zanchetti A., Crepaldi G., Bond M.G., et al. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study. PHYLLIS study group. J Hypertens 2001, 19:79-88.
19. Vasankari T., Ahotupa M., Viikari J., et al. Effects of statin therapy on circulating conjugated dienes, a measure of LDL oxidation. Atherosclerosis 2005, 179:207-209.
20. Homma Y., Michisita I., Hayashi H., Shigematsu H., Kanagawa Lipid Research Group Effects of low-dose simvastatin on the distribution of plasma cholesterol and oxidized low-density lipoprotein in three ultracentrifugally separated low-density lipoprotein subfractions: 12-month, open-label trial. J Atheroscler Thromb 2010, 17:1049-1053.
21. Schneider M.P., Schmidt B.M., John S., Schmieder R.E. Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels. J Hypertens 2011, 29:1757-1764.
22. Yamaguchi Y., Kagota S., Haginaka J., Kunitomo M. Participation of peroxynitrite in oxidative modification of LDL aqueous extracts of cigarette smoke. FEBS Lett 2002, 512:218-222.
23. Valkonen M., Kuusi T. Passive smoking induces atherogenic changes in low-density lipoprotein. Circulation 1998, 97:2012-2016.
24. Chen C., Loo G. Cigarette smoke extract inhibits oxidative modification of low density lipoprotein. Atherosclerosis 1995, 112:177-185.
25. Berni A., Giuliani A., Tartaglia F., et al. Effect of vascular risk factors on increase in carotid and femoral intima-media thickness. Identification of a risk scale. Atherosclerosis 2011, 216:109-114.
26. Ahotupa M., Marniemi J., Lehtimäki T., et al. Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation. Clin Biochem 1998, 31:257-261.
27. Vasankari T., Lehtonen-Veromaa M., Möttönen T., et al. Reduced mildly oxidized LDL in young female athletes. Atherosclerosis 2000, 151:399-405.
28. Kosola J, Ahotupa M, Kyrolainen H, Santtila M, Vasankari T. Good aerobic or muscular fitness prevents overweight men from elevated oxidized LDL. Med Sci Sports Exerc. doi:10.1249/MSS.0b013e31823822cc.
29. Kontush A., Chapman M.J. Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities. Curr Opin Lipidol 2010, 21:312-318.
30. Hulthe J., Wiklund O., Hurt-Camejo E., Bondjers G. Autoantibodies to oxidized LDL in relation to carotid atherosclerosis, cell adhesion molecules, and phospholipase A(2). Arterioscler Thromb Vasc Biol 2001, 21:269-274.