Novel thermogelling dispersions of polymer nanoparticles for controlled protein release

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 8, 2012, Pages 1301-1308

  Cai, Tong ^a   Hu, Peter D ^b,c   Sun, Manwu ^b   Zhou, Jun ^b   Tsai, Yi Ting ^b   Baker, David ^b   Tang, Liping ^b  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b University of Texas at Arlington   (United States)

^c Texas Academy of Mathematics and Science   (United States)

Author keywords

Controlled drug release; Injectable; Temperature sensitive nanoparticle; Thermogelling

Indexed keywords

ATOMIC FORCE; BODY TEMPERATURE; CONTROLLED DRUG RELEASE; DYNAMIC LIGHT SCATTERING METHOD; ETHYL ETHER; HISTOLOGICAL ANALYSIS; IN-SITU; IN-VITRO; INJECTABLE; INTERPENETRATING NETWORK (IPN); METHYL ETHERS; MICROSCOPIC IMAGE; MODEL PROTEINS; MONODISPERSE; OLIGO(ETHYLENE GLYCOL); POLY(ACRYLIC ACID ); POLYMER NANOPARTICLES; POLYMERIC NANOPARTICLES; PROTEIN RELEASE; SLOW RELEASE; TEMPERATURE-RESPONSIVE; TEMPERATURE-SENSITIVE; THERMOGELLING; VISUAL OBSERVATIONS;

CARBOXYLIC ACIDS; ETHERS; ETHYLENE GLYCOL; HYDROGELS; MIXING; NANOPARTICLES; ORGANIC COMPOUNDS; POLYMERS; PROTEINS;

SYNTHESIS (CHEMICAL);

BOVINE SERUM ALBUMIN; INSULIN; NANOPARTICLE; POLY(OLIGO(ETHYLENE GLYCOL)METHYL ETHER METHACRYLATE CO OLIGO(ETHYLENE GLYCOL)ETHYL ETHER METHACRYLATE)POLY(ACRYLIC ACID); POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOCOMPATIBILITY; BODY TEMPERATURE; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; GEL; HYDROGEL; IMPLANT; LIGHT SCATTERING; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; POLYMERIZATION; TEMPERATURE SENSITIVITY; THERMOGELLING; VISCOSITY;

ACRYLIC RESINS; HUMANS; HYDROGEN-ION CONCENTRATION; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; PROTEINS; SURFACE PROPERTIES; TEMPERATURE; VISCOSITY;

EID: 84867880598     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.02.002     Document Type: Article

References (50)

1. Peppas N.A., Langer R. New challenges in biomaterials. Science 1994, 263:1715-1720.
2. Ron E.S., Bromberg L.E. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Deliv Rev 1998, 31:197-221.
3. Alexandridis P., Hatton T.A. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block-copolymer surfactants in aqueous solutions and at interfaces-thermodynamics, structure, dynamics, and modeling. Colloid Surface A 1995, 96:1-46.
4. Kim Y.J., Choi S., Koh J.J., Lee M., Ko K.S., Kim S.W. Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm Res 2001, 18:548-550.
5. Jeong B., Kim S.W., Bae Y.H. Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev 2002, 54:37-51.
6. Stile R.A., Healy K.E. Poly(N-isopropylacrylamide)-based semi-interpenetrating polymer networks for tissue engineering applications. 1. Effects of linear poly(acrylic acid) chains on phase behavior. Biomacromolecules 2002, 3:591-600.
7. Xia X.H., Hu Z.B. Synthesis and light scattering study of microgels with interpenetrating polymer networks. Langmuir 2004, 20:2094-2098.
8. Zhou J., Wang G., Zou L., Tang L., Marquez M., Hu Z.B. Viscoelastic behavior and in vivo release study of microgel dispersions with inverse thermoreversible gelation. Biomacromolecules 2008, 9:142-148.
9. Hirotsu S., Hirokawa Y., Tanaka T. Volume-phase transitions of ionized nisopropylacrylamide gels. J Chem Phys 1987, 87:1392-1395.
10. Gan T.T., Zhang Y.J., Guan Y. In situ gelation of P(NIPAM-HEMA) microgel dispersion and its applications as injectable 3D cell scaffold. Biomacromolecules 2009, 10:1410-1415.
11. Ankareddi I., Bailey M.M., Brazel C.S., Rasco J.E., Hood R.D. Developmental toxicity assessment of thermoresponsive poly(N-isopropylacrylamide-co-acrylamide) oligomers in CD-1 mice. Birth Defects Res B Dev Reprod Toxicol 2008, 83:112-116.
12. Dimitrov I., Trzebicka B., Muller A.H.E., Dworak A., Tsvetanov C.B. Thermosensitive water-soluble copolymers with doubly responsive reversibly interacting entities. Prog Polym Sci 2007, 32:1275-1343.
13. Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003, 2:347-360.
14. Greenwald R.B., Choe Y.H., McGuire J., Conover C.D. Effective drug delivery by PEGylated drug conjugates. Adv Drug Deliv Rev 2003, 55:217-250.
15. Lutz J.F., Akdemir O., Hoth A. Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over?. J Am Chem Soc 2006, 128:13046-13047.
16. Lutz J.F. Polymerization of oligo(ethylene glycol) (meth)acrylates: toward new generations of smart biocompatible materials. J Polym Sci Part A: Polym Chem 2008, 46:3459-3470.
17. Cai T., Marquez M., Hu Z.B. Monodisperse thermoresponsive microgels of poly(ethylene glycol) analogue-based biopolymers. Langmuir 2007, 23:8663-8666.
18. Banet P., Griesmar P., Serfaty S., Vidal F., Jaouen V., Huerou J.Y.L. One-shot synthesis of a poly(N-isopropylacrylamide)/silica hybrid gel. J Phys Chem B 2009, 113:14914-14919.
19. Schmitz K.S. An introduction to dynamic light scattering by macromolecules 1990, Academic Press, Harcourt Brace Jovanovich Publishers, Boston.
20. Berne B.J., Pecora R. Dynamic light scattering: with applications to chemistry, biology, and physics 1976, Wiley Interscience, New York.
21. Provencher S.W. Inverse problems in polymer characterization-direct analysis of polydispersity with photon correlation spectroscopy. Macromol Chem Phys 1979, 180:201-209.
22. Gao J., Hu Z.B. Optical properties of N-isopropylacrylamide microgel spheres in water. Langmuir 2002, 18:1360-1367.
23. Chen J.L., Chiang C.H., Yeh M.K. The mechanism of PLA microparticle formation by water-in-oil-in-water solvent evaporation method. J Microencapsul 2002, 19:333-346.
24. Kamath S., Bhattacharyya D., Padukudru C., Timmons R.B., Tang L. Surface chemistry influences implant-mediated host tissue responses. J Biomed Mater Res A 2008, 86A:617-626.
25. Nair A., Zou L., Bhattacharyya D., Timmons R.B., Tang L. Species and density of implant surface chemistry affect the extent of foreign body reactions. Langmuir 2008, 24:2015-2024.
26. Sheffield J.B. ImageJ, a useful tool for biological image processing and analysis. Microsc Microanal 2007, 13:200-201.
27. Yoshimura A., Ohnishi S. Uncoating of influenza-virus in endosomes. J Virol 1984, 51:497-504.
28. Xia X.H., Hu Z.B., Marquez M. Physically bonded nanoparticle networks: a novel drug delivery system. J Control Release 2005, 103:21-30.
29. Weng H., Zhou J., Tang L., Hu Z.B. Tissue responses to thermally-responsive hydrogel nanoparticles. J Biomat Sci-Polym E 2004, 15:1167-1180.
30. Gulati N., Rastogi R., Dinda A.M., Saxena R., Koul V. Characterization and cell material interactions of PEGylated PNIPAAM nanoparticles. Colloid Surface B 2010, 79:164-173.
31. Yang A., Liu W., Li Z., Jiang L., Xu H., Yang X. Influence of polyethylene glycol modification on phagocytic uptake of polymeric nanoparticles mediated by immunoglobulin G and complement activation. J Nanosci Nanotechnol 2010, 10:622-628.
32. Herten M., Jung R.E., Ferrari D., Rothamel D., Golubovic V., Molenberg A., et al. Biodegradation of different synthetic hydrogels made of polyethylene glycol hydrogel/RGD-peptide modifications: an immunohistochemical study in rats. Clin Oral Implant Res 2009, 20:116-125.
33. Reis C.P., Ribeiro A.J., Houng S., Veiga F., Neufeld R.J. Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity. Eur J Pharm Sci 2007, 30:392-397.
34. Polli J.E. In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms. AAPS J 2008, 10:289-299.
35. Weissleder R., Tung C.H., Mahmood U., Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17:375-378.
36. Rao J., Dragulescu-Andrasi A., Yao H. Fluorescence imaging in vivo: recent advances. Curr Opin Biotechnol 2007, 18:17-25.
37. Liu S., Jia B., Qiao R., Yang Z., Yu Z., Liu Z., et al. A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application. Mol Pharm 2009, 6:1074-1082.
38. Lee J.Y., Kang Y.M., Kim E.S., Kang M.L., Lee B., Kim J.H., et al. In vitro and in vivo release of albumin from an electrostatically crosslinked in situ-forming gel. J Mater Chem 2010, 20:3265-3271.
39. Smitha B., Sridhar S., Khan A.A. Polyelectrolyte complexes of chitosan and poly(acrylic acid) as proton exchange membranes for fuel cells. Macromolecules 2004, 37:2233-2239.
40. Hu Y., Jiang X.Q., Ding Y., Ge H.X., Yuan Y.Y., Yang C.Z. Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles. Biomaterials 2002, 23:3193-3201.
41. Ikawa T., Abe K., Honda K., Tsuchida E. Interpolymer complex between poly(ethylene oxide) and poly(carboxylic acid). J Polym Sci Part A Polym Chem 1975, 13:1505-1514.
42. Oyama H.T., Tang W.T., Frank C.W. Complex formation between poly(acrylic acid) and pyrene-labeled poly(ethylene glycol) in aqueous solution. Macromolecules 1987, 20:474-480.
43. Kim S.Y., Kim H.J., Lee K.E., Han S.S., Sohn Y.S., Jeong B. Reverse thermal gelling PEG-PTMC diblock copolymer aqueous solution. Macromolecules 2007, 40:5519-5525.
44. Fechler N., Badi N., Schade K., Pfeifer S., Lutz J.F. Thermogelation of PEG-based macromolecules of controlled architecture. Macromolecules 2009, 42:33-36.
45. Badi N., Lutz J.F. PEG-based thermogels: applicability in physiological media. J Control Release 2009, 140:224-229.
46. Hoffmann J., Groll J., Heuts J., Rong H., Klee D., Ziemer G., et al. Blood cell and plasma protein repellent properties of Star-PEG-modified surfaces. J Biomat Sci-Polym E 2006, 17:985-996.
47. Yang X., Kim J.C. Beta-cyclodextrin hydrogels containing naphthaleneacetic acid for pH-sensitive release. Biotechnol Bioeng 2010, 106:295-302.
48. Nam K., Watanabe J., Ishihara K. The characteristics of spontaneously forming physically cross-linked hydrogels composed of two water-soluble phospholipid polymers for oral drug delivery carrier I: hydrogel dissolution and insulin release under neutral pH condition. Eur J Pharm Sci 2004, 23:261-270.
49. Rasool N., Yasin T., Heng J.Y.Y., Akhter Z. Synthesis and characterization of novel pH-, ionic strength- and temperature-sensitive hydrogel for insulin delivery. Polymer 2010, 51:1687-1693.
50. Yin L., Ding J., Zhang J., He C., Tang C., Yin C. Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin. Biomaterials 2010, 31:3347-3356.